Ping Te Cao

US Patent:

6863790, Mar 8, 2005

Filed:

Aug 5, 1999

Appl. No.:

09/370781

Inventors:

Mehdi Moini - Austin TX, US
Ping Cao - San Mateo CA, US

Assignee:

Board of Regents University of Texas System - Austin TX

International Classification:

G01N027/447
G01N030/72

US Classification:

204452, 204454, 204603, 250288

Abstract:

A simple and rugged sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry (CE/ESI-MS) was designed using common laboratory tools and chemicals. The interface uses a small platinum (Pt) wire which is inserted into the CE capillary through a small hole near the terminus. The position of the wire inside the CE capillary and within the buffer solution is analogous to standard CE separation operations where the terminus of the CE capillary is placed inside a buffer reservoir along with a grounded platinum electrode. By combining the use of the in-capillary electrode interface with sharpening of the fused silica tip of the CE capillary outlet, a stable electrospray current was maintained for an extended period of time. The design was successfully applied to CE/ESI-MS separations and analysis of mixtures of peptides and proteins. A detection limit of approximately 4 femtomole (S/N=3) was achieved for detection of myoglobin utilizing a 75 μm-i. d.

US Patent:

20220288069, Sep 15, 2022

Filed:

Jul 17, 2020

Appl. No.:

17/626486

Inventors:

- San Jose CA, US
Ping Cao - San Jose CA, US
Michael J. Bishop - San Jose CA, US

International Classification:

A61K 31/506
C07D 403/12
C07D 413/14
C07D 403/14
C07D 417/12
C07D 417/14
C07D 403/06
C07D 209/34
A61K 45/06
A61K 31/5377
A61K 31/4439
A61K 31/404

Abstract:

The present disclosure provides compounds and compositions thereof which are useful as inhibitors of tyrosine kinase and which exhibit desirable characteristics for the same. Further disclosed herein are methods of treating cancer using these tyrosine kinase inhibitor compounds.