Ping Cao

US Patent:

20180319860, Nov 8, 2018

Filed:

Jul 11, 2018

Appl. No.:

16/032328

Inventors:

- Albany NY, US
Hui WANG - East Setauket NY, US
Ping CAO - New York NY, US
Andisheh ABEDINI - New York NY, US

Assignee:

The Research Foundation for The State University of New York - Albany NY

International Classification:

C07K 14/575
C07K 14/00
A61K 38/28
A61K 38/22
A61K 38/00

Abstract:

Isolated non-naturally occurring, mutant-human islet amyloid polypeptides (hIAPP) are disclosed. These polypeptides can be formulated or co-formulated at physiological pH, which enable the polypeptides of the instant disclosure to be delivered to a subject having an amyloid-based disease in a single injection with an insulin agent. Methods and compositions for treating amyloid-based disease in a subject in need thereof, by administering an effective amount of an isolated, mutant-hIAPP polypeptide, including formulations or co-formulations thereof are also disclosed.

US Patent:

20170051032, Feb 23, 2017

Filed:

May 1, 2015

Appl. No.:

15/308138

Inventors:

- Albany NY, US
Hui WANG - East Setauket NY, US
Ping CAO - New York NY, US
Andisheh ABEDINI - New York NY, US

Assignee:

THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK - Albany NY

International Classification:

C07K 14/575
A61K 38/28
A61K 38/22
C07K 14/00

Abstract:

The present disclosure provides for isolated non-naturally occurring, mutant-human IAPP polypeptides. These polypeptides can be formulated or co-formulated at physiological pH, which enable the polypeptides of the instant disclosure to be delivered to a subject having an amyloid-based disease in a single injection with an insulin agent. The present disclosure also provides methods and compositions for treating amyloid-based disease in a subject in need thereof, comprising administering an effective amount of an isolated, mutant-hIAPP polypeptide, including formulations or co-formulations thereof.