Ping Chen

US Patent:

20180354957, Dec 13, 2018

Filed:

Aug 8, 2018

Appl. No.:

16/058299

Inventors:

Konstantin Petrukhin - New Windsor NY, US
Christopher Cioffi - Albany NY, US
Graham Johnson - Sanbornton NH, US
Rando Allikmets - Cornwall on Hudson NY, US
Emily Freeman - Albany NY, US
Ping Chen - Albany NY, US
Michael Conlon - Albany NY, US
Lei Zhu - Albany NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C07D 487/04
C07D 471/04

Abstract:

The present invention provides a compound having the structure:or a pharmaceutically acceptable salt thereof.

US Patent:

20180298012, Oct 18, 2018

Filed:

Apr 11, 2018

Appl. No.:

15/950528

Inventors:

Konstantin Petrukhin - New Windsor NY, US
Christopher Cioffi - Albany NY, US
Graham Johnson - Sanbornton NH, US
Nicoleta Dobri - New York NY, US
Emily Freeman - Albany NY, US
Ping Chen - Albany NY, US
Michael Conlon - Albany NY, US
Lei Zhu - Albany NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C07D 487/04
C07D 519/00
C07D 209/52
C07D 498/04
C07D 403/04
C07D 403/06
C07D 401/12
C07D 403/12
C07D 471/04

Abstract:

The present invention provides compounds comprising variously substituted octahydropyrrolopyrroles, their synthesis, methods of making, methods of using, compositions and formulations thereof.

US Patent:

20180222919, Aug 9, 2018

Filed:

Apr 3, 2018

Appl. No.:

15/944334

Inventors:

Konstantin Petrukhin - New Windsor NY, US
Christopher Cioffi - Albany NY, US
Graham Johnson - Sanbornton NH, US
Nicoleta Dobri - New York NY, US
Emily Freeman - Albany NY, US
Ping Chen - Albany NY, US
Michael Conlon - Albany NY, US
Lei Zhu - Albany NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C07D 498/04
C07D 213/79
C07D 213/80
C07D 231/56
C07D 237/24
C07C 233/56
C07D 249/04
C07D 471/04
C07D 487/04
C07D 491/052
C07D 239/28

Abstract:

The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is absent or present, and when present is —C(O)— or —C(O)NH—; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is —C(O)—, or a pharmaceutically acceptable salt thereof.

US Patent:

20180030060, Feb 1, 2018

Filed:

Oct 2, 2017

Appl. No.:

15/722760

Inventors:

Konstantin Petrukhin - New Windsor NY, US
Christopher Cioffi - Albany NY, US
Graham Johnson - Sanbornton NH, US
Rando Allikmets - Cornwall on Hudson NY, US
Emily Freeman - Albany NY, US
Ping Chen - Albany NY, US
Michael Conlon - Albany NY, US
Lei Zhu - Albany NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C07D 487/04
C07D 471/04

Abstract:

The present invention provides a compound having the structure:or a pharmaceutically acceptable salt thereof.

US Patent:

20170247327, Aug 31, 2017

Filed:

Mar 13, 2017

Appl. No.:

15/457821

Inventors:

Konstantin Petrukhin - New Windsor NY, US
Christopher Cioffi - Albany NY, US
Graham Johnson - Sanbornton NH, US
Nicoleta Dobri - New York NY, US
Emily Freeman - Albany NY, US
Ping Chen - Albany NY, US
Michael Conlon - Albany NY, US
Lei Zhu - Albany NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C07D 209/52
C07D 471/04
C07D 498/04
C07D 401/04
C07D 401/12
C07D 403/04
C07D 403/12
C07D 403/06
C07D 487/04

Abstract:

The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is C(O) or C(O)NH; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is C(O); and when psi is present, then R6 is absent and when psi is absent, then R6 is present, or a pharmaceutically acceptable salt thereof, for treatment of diseases characterized by excessive lipofuscin accumulation in the retina.

US Patent:

20160368925, Dec 22, 2016

Filed:

Sep 1, 2016

Appl. No.:

15/254966

Inventors:

Konstantin Petrukhin - New Windsor NY, US
Christopher Cioffi - Albany NY, US
Graham Johnson - Sanbornton NH, US
Rando Allikmets - Cornwall on Hudson NY, US
Emily Freeman - Albany NY, US
Ping Chen - Albany NY, US
Michael Conlon - Albany NY, US
Lei Zhu - Albany NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C07D 487/04
C07D 471/04

Abstract:

The present invention provides a compound having the structure:or a pharmaceutically acceptable salt thereof.

US Patent:

20160046648, Feb 18, 2016

Filed:

Mar 13, 2014

Appl. No.:

14/775532

Inventors:

Konstantin PETRUKHIN - New Windsor NY, US
Christopher CIOFFI - Albany NY, US
Graham JOHNSON - Sanbornton NH, US
Nicoleta DOBRI - , US
Emily FREEMAN - , US
Ping CHEN - Albany NY, US
Michael CONLON - Albany NY, US
Lei ZHU - Albany NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C07D 498/04
C07D 495/04
C07D 409/06
C07D 487/04
C07D 405/14
C07D 401/06
C07D 491/052
C07D 471/04

Abstract:

The present invention provides a compound having the structure: (structurally represented) wherein R, R, R, R, and Rare each independently H, halogen, CFor C-Calkyl; Ris H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.

US Patent:

20160046649, Feb 18, 2016

Filed:

Mar 13, 2014

Appl. No.:

14/775546

Inventors:

Konstantin PETRUKHIN - New Windsor NY, US
Christopher CIOFFI - Albany NY, US
Graham JOHNSON - Sabornton, NH, US
Nicoleta DOBRI - New York NY, US
Emily FREEMAN - Albany NY, US
Ping CHEN - Albany NY, US
Michael CONLON - Albany NY, US
Lei ZHU - Albany NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C07D 498/04
C07D 249/04
C07D 487/04
C07D 213/79
C07D 239/28
C07D 237/24
C07D 471/04
C07C 233/56

Abstract:

The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is absent or present, and when present is —C(O)— or —C(O)NH—; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is —C(O)—, or a pharmaceutically acceptable salt thereof.