Ping C Chen

US Patent:

6344179, Feb 5, 2002

Filed:

Apr 21, 2000

Appl. No.:

09/553795

Inventors:

Mark M. Goodman - Atlanta GA
Ping Chen - Indianapolis IN

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 5100

US Classification:

424 189, 424 185, 546124, 546132

Abstract:

Provided are compounds of the following formula: wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.

US Patent:

6399042, Jun 4, 2002

Filed:

Apr 26, 2000

Appl. No.:

09/558916

Inventors:

Mark M. Goodman - Atlanta GA
Ping Chen - Indianapolis IN

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 5100

US Classification:

424 185, 424 189, 546124, 546132

Abstract:

A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes family are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.