Ping Y Chen

US Patent:

6344179, Feb 5, 2002

Filed:

Apr 21, 2000

Appl. No.:

09/553795

Inventors:

Mark M. Goodman - Atlanta GA
Ping Chen - Indianapolis IN

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 5100

US Classification:

424 189, 424 185, 546124, 546132

Abstract:

Provided are compounds of the following formula: wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.

US Patent:

6399042, Jun 4, 2002

Filed:

Apr 26, 2000

Appl. No.:

09/558916

Inventors:

Mark M. Goodman - Atlanta GA
Ping Chen - Indianapolis IN

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 5100

US Classification:

424 185, 424 189, 546124, 546132

Abstract:

A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes family are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.

US Patent:

6596746, Jul 22, 2003

Filed:

Apr 13, 2000

Appl. No.:

09/548929

Inventors:

Jagabandhu Das - Mercerville NJ
Ramesh Padmanabha - Hamden CT
Ping Chen - Belle Mead NJ
Derek J. Norris - Trenton NJ
Arthur M. P. Doweyko - Long Valley NJ
Joel C. Barrish - Holland PA
John Wityak - Robbinsville NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D27742

US Classification:

514370, 548194

Abstract:

Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.

US Patent:

6979694, Dec 27, 2005

Filed:

Mar 3, 2003

Appl. No.:

10/378372

Inventors:

Jagabandhu Das - Mercerville NJ, US
Ramesh Padmanabha - Hamden CT, US
Ping Chen - Belle Mead NJ, US
Derek J. Norris - Trenton NJ, US
Arthur M. P. Doweyko - Long Valley NJ, US
Joel C. Barrish - Holland PA, US
John Wityak - Robbinsville NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K031/426
A61K031/44
C07D277/20
C07D417/12

US Classification:

514342, 514371, 5462707, 548195, 544106, 544133

Abstract:

Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.

US Patent:

7091223, Aug 15, 2006

Filed:

Mar 3, 2003

Appl. No.:

10/378461

Inventors:

Jagabandhu Das - Mercerville NJ, US
Ramesh Padmanabha - Hamden CT, US
Ping Chen - Belle Mead NJ, US
Derek J. Norris - Trenton NJ, US
Arthur M. P. Doweyko - Long Valley NJ, US
Joel C. Barrish - Holland PA, US
John Wityak - Robbinsville NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/4439
C07D 417/12

US Classification:

514342, 5462707

Abstract:

Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.

US Patent:

7125875, Oct 24, 2006

Filed:

Mar 24, 2003

Appl. No.:

10/395503

Inventors:

Jagabandhu Das - Mercerville NJ, US
Ramesh Padmanabha - Hamden CT, US
Ping Chen - Belle Mead NJ, US
Derek J. Norris - Trenton NJ, US
Arthur M. P. Doweyko - Long Valley NJ, US
Joel C. Barrish - Richboro PA, US
John Wityak - Robbinsville NJ, US
Louis J. Lombardo - Belle Mead NJ, US
Francis Y. F. Lee - Yardley PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/427
A61K 31/496
A61K 31/501

US Classification:

51425219, 514370

Abstract:

Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.

US Patent:

7153856, Dec 26, 2006

Filed:

May 26, 2005

Appl. No.:

11/138942

Inventors:

Joel C. Barrish - Richboro PA, US
John Wityak - Carlsbad CA, US
Jagabandhu Das - Mercerville NJ, US
Ping Chen - Belle Mead NJ, US
Derek J. Norris - Pennington NJ, US
Gary Schieven - Lawrenceville NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/497
C07D 241/02

US Classification:

51425211, 544357

Abstract:

Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.

US Patent:

7189854, Mar 13, 2007

Filed:

May 26, 2005

Appl. No.:

11/138793

Inventors:

Jagabandhu Das - Mercerville NJ, US
Ping Chen - Belle Mead NJ, US
Derek J. Norris - Trenton NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 401/00
C07D 233/44

US Classification:

5462701, 5483321

Abstract:

Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.