Ping J Chen

US Patent:

7812027, Oct 12, 2010

Filed:

May 11, 2007

Appl. No.:

12/226584

Inventors:

Tesfaye Biftu - Freehold NJ, US
Ping Chen - Edison NJ, US
Danqing Feng - Green Brook NJ, US
Ann E. Weber - Scotch Plains NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/50

US Classification:

51425505, 544350, 549424

Abstract:

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

7910596, Mar 22, 2011

Filed:

Feb 9, 2007

Appl. No.:

12/223143

Inventors:

Tesfaye Biftu - Freehold NJ, US
Charles G Caldwell - Dallas TX, US
Ann E. Weber - Scotch Plains NJ, US
Ping P Chen - Edison NJ, US
Xiaoxia Qian - New York NY, US
Danqing Feng - Branchburg NJ, US
Jason M. Cox - East Windsor NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A01N 43/90
A61K 31/519
C07D 487/00

US Classification:

5142651, 544280

Abstract:

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

7928112, Apr 19, 2011

Filed:

Aug 27, 2010

Appl. No.:

12/869869

Inventors:

Tesfaye Biftu - Freehold NJ, US
Ping Chen - Edison NJ, US
Danqing Feng - Green Brook NJ, US
Ann E. Weber - Scotch Plains NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/519

US Classification:

5142641, 544279, 549424

Abstract:

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

8143289, Mar 27, 2012

Filed:

Nov 12, 2009

Appl. No.:

12/616831

Inventors:

Tesfaye Biftu - Freehold NJ, US
Ping Chen - Edison NJ, US
Jason M. Cox - East Windsor NJ, US
Ann E. Weber - Scotch Plains NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/4439
A61K 31/4162
A61P 3/10
C07D 401/14
C07D 487/04

US Classification:

514338, 514407, 5462757, 5483605

Abstract:

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

8455533, Jun 4, 2013

Filed:

Aug 23, 2010

Appl. No.:

13/390538

Inventors:

Tesfaye Biftu - Freehold NJ, US
Ping Chen - Edison NJ, US
Danqing Feng - Green Brook NJ, US
Xiaoxia Qian - New York NY, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/4162
C07D 231/00

US Classification:

514406, 5483605

Abstract:

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

20120149637, Jun 14, 2012

Filed:

Feb 17, 2012

Appl. No.:

13/398887

Inventors:

Tesfaye Biftu - Freehold NJ, US
Ping Chen - Edison NJ, US
Jason M. Cox - East Windsor NJ, US
Ann E. Weber - Scotch Plains NJ, US

International Classification:

A61K 31/4162
A61K 38/28
A61P 3/10
C07D 487/04

US Classification:

514 65, 5483605, 514407

Abstract:

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

20130123237, May 16, 2013

Filed:

Feb 23, 2012

Appl. No.:

13/812536

Inventors:

Rajan Anand - Fanwood NJ, US
James M. Apgar - Highland Park NJ, US
Tesfaye Biftu - Freehold NJ, US
Ping Chen - Edison NJ, US
Lin Chu - Scotch Plains NJ, US
Vincent J. Colandrea - North Brunswick NJ, US
Guizhen Dong - Dayton NJ, US
James F. Dropinski - Colts Neck NJ, US
Danqing Feng - Green Brook NJ, US
Jacqueline D. Hicks - Scotch Plains NJ, US
Jinlong Jiang - Scotch Plains NJ, US
Alexander J. Kim - Morganville NJ, US
Kenneth J. Leavitt - Plainsboro NJ, US
Bing Li - Towaco NJ, US
Xiaoxia Qian - New York NY, US
Iyassu Sebhat - Jersey City NJ, US
Lan Wei - Berkeley Heights NJ, US
Robert R. Wilkening - Maplewood NJ, US
Zhicai Wu - Montvale NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/5377
A61K 31/437
A61K 31/4985
A61K 31/351
A61K 31/397
A61K 31/4412
C07D 471/04
A61K 31/496

US Classification:

51421021, 546118, 514303, 544362, 51425304, 544127, 5142342

Abstract:

Novel compounds of structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

US Patent:

20130203786, Aug 8, 2013

Filed:

May 16, 2011

Appl. No.:

13/643121

Inventors:

Jacqueline D. Hicks - Scotch Plains NJ, US
Tesfaye Biftu - Freehold NJ, US
Ping Chen - Edison NJ, US
Xiaoxia Qian - New York NY, US
Robert R. Wilkening - Maplewood NJ, US

International Classification:

C07D 487/04
A61K 31/506
A61K 45/06
A61K 31/519
A61K 31/437
A61K 31/4162
A61K 31/4439

US Classification:

5142641, 5483565, 514407, 514275, 544331, 5462757, 514338, 544280, 5142651, 514303, 546119, 544279

Abstract:

The present invention is directed to novel amino-substituted seven-membered heterocyclic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.