Ping Que Chen

US Patent:

6344179, Feb 5, 2002

Filed:

Apr 21, 2000

Appl. No.:

09/553795

Inventors:

Mark M. Goodman - Atlanta GA
Ping Chen - Indianapolis IN

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 5100

US Classification:

424 189, 424 185, 546124, 546132

Abstract:

Provided are compounds of the following formula: wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.

US Patent:

6399042, Jun 4, 2002

Filed:

Apr 26, 2000

Appl. No.:

09/558916

Inventors:

Mark M. Goodman - Atlanta GA
Ping Chen - Indianapolis IN

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 5100

US Classification:

424 185, 424 189, 546124, 546132

Abstract:

A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes family are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.

US Patent:

8000737, Aug 16, 2011

Filed:

Jan 15, 2007

Appl. No.:

11/623307

Inventors:

Frank M. Caimi - Vero Beach FL, US
Ping Chen - Greensboro NC, US
Young-Min Jo - Viera FL, US

Assignee:

Sky Cross, Inc. - Melbourne FL

International Classification:

H04M 1/00
H04B 1/04
H04Q 11/12

US Classification:

4555501, 455103, 4551273

Abstract:

A communications apparatus comprising a first antenna, a first serial configuration of a first power amplifier and a first matching network, a second serial configuration of a second power amplifier and a second matching network, a switching element for switchably selecting the first or the second serial configuration for supplying a signal to the first antenna, the first and the second power amplifiers supplying a respective first signal of a first power and a second signal of a second power different than the first power to the first antenna for transmitting and the first and the second matching networks presenting respective first and second impedances to the respective first and second power amplifiers, the first and the second impedances responsive respectively to a power-related parameter of the first and the second signals.

US Patent:

20120019420, Jan 26, 2012

Filed:

Aug 15, 2011

Appl. No.:

13/209707

Inventors:

Frank M. Caimi - Vero Beach FL, US
Ping Chen - Greensboro NC, US
Young-Min Jo - Viera FL, US

International Classification:

H01Q 1/50
H01P 11/00
H01Q 1/24

US Classification:

343702, 29600

Abstract:

A modular communications apparatus. The apparatus comprises a dielectric substrate, a radiating structure disposed on a surface of the substrate, and an electronics module disposed within the dielectric substrate. The electronics module comprises a power amplifier and signal receiving components. The apparatus further comprises fixed length transmission lines connecting the radiating structure and the electronics module, a length of each transmission line selected to present a desired impedance at an input and an output terminal of each transmission line without requiring separate impedance matching elements.

US Patent:

20130123237, May 16, 2013

Filed:

Feb 23, 2012

Appl. No.:

13/812536

Inventors:

Rajan Anand - Fanwood NJ, US
James M. Apgar - Highland Park NJ, US
Tesfaye Biftu - Freehold NJ, US
Ping Chen - Edison NJ, US
Lin Chu - Scotch Plains NJ, US
Vincent J. Colandrea - North Brunswick NJ, US
Guizhen Dong - Dayton NJ, US
James F. Dropinski - Colts Neck NJ, US
Danqing Feng - Green Brook NJ, US
Jacqueline D. Hicks - Scotch Plains NJ, US
Jinlong Jiang - Scotch Plains NJ, US
Alexander J. Kim - Morganville NJ, US
Kenneth J. Leavitt - Plainsboro NJ, US
Bing Li - Towaco NJ, US
Xiaoxia Qian - New York NY, US
Iyassu Sebhat - Jersey City NJ, US
Lan Wei - Berkeley Heights NJ, US
Robert R. Wilkening - Maplewood NJ, US
Zhicai Wu - Montvale NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/5377
A61K 31/437
A61K 31/4985
A61K 31/351
A61K 31/397
A61K 31/4412
C07D 471/04
A61K 31/496

US Classification:

51421021, 546118, 514303, 544362, 51425304, 544127, 5142342

Abstract:

Novel compounds of structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

US Patent:

20130154894, Jun 20, 2013

Filed:

Oct 5, 2012

Appl. No.:

13/646012

Inventors:

Frank M. Caimi - Vero Beach FL, US
Ping Chen - Greensboro NC, US
Young-Min Jo - Viera FL, US

International Classification:

H01Q 1/50

US Classification:

343858

Abstract:

A communications apparatus. The apparatus comprises a transmitting antenna, a receiving antenna, a first serial configuration of a first power amplifier and a first matching network for producing a first signal, the first power amplifier operating in a first frequency band, a second serial configuration of a second power amplifier and a second matching network for producing a second signal, the second power amplifier operating in a second frequency band, a first switching element for switchably supplying the first signal or the second signal to the transmitting antenna, a first and a second receiver; and a second switching element for switchably directing a signal received at the receiving antenna to the first receiver or the second receiver.

US Patent:

20130203786, Aug 8, 2013

Filed:

May 16, 2011

Appl. No.:

13/643121

Inventors:

Jacqueline D. Hicks - Scotch Plains NJ, US
Tesfaye Biftu - Freehold NJ, US
Ping Chen - Edison NJ, US
Xiaoxia Qian - New York NY, US
Robert R. Wilkening - Maplewood NJ, US

International Classification:

C07D 487/04
A61K 31/506
A61K 45/06
A61K 31/519
A61K 31/437
A61K 31/4162
A61K 31/4439

US Classification:

5142641, 5483565, 514407, 514275, 544331, 5462757, 514338, 544280, 5142651, 514303, 546119, 544279

Abstract:

The present invention is directed to novel amino-substituted seven-membered heterocyclic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

US Patent:

20140080884, Mar 20, 2014

Filed:

Jun 25, 2012

Appl. No.:

14/118998

Inventors:

Itzia Arroyo - Union NJ, US
Davida Krueger - Brooklyn NY, US
Ping Chen - Edison NJ, US
Aaron Moment - Middletown NJ, US
Tesfaye Biftu - Freehold NJ, US
Faye Sheen - Hoddesdon, GB
Yanfeng Zhang - Panan, Zhejiang, CN

Assignee:

Merck Sharp & Dohme Ltd. - Hoddesdon, Hertfordshire
Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 487/04

US Classification:

514407, 5483605

Abstract:

Novel crystalline forms of (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine are potent inhibitors of dipeptidyl peptidase-IV and are useful for the treatment of non-insulin dependent (Type 2) diabetes mellitus. The invention also relates to pharmaceutical compositions containing these novel forms, processes to prepare these forms and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes.

Address:

1000 Bitting St APT D, Greensboro, NC 27403

VIN:

1HGCM56447A083351

Make:

HONDA

Model:

ACCORD

Year:

2007