Ping Chen

US Patent:

6596746, Jul 22, 2003

Filed:

Apr 13, 2000

Appl. No.:

09/548929

Inventors:

Jagabandhu Das - Mercerville NJ
Ramesh Padmanabha - Hamden CT
Ping Chen - Belle Mead NJ
Derek J. Norris - Trenton NJ
Arthur M. P. Doweyko - Long Valley NJ
Joel C. Barrish - Holland PA
John Wityak - Robbinsville NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D27742

US Classification:

514370, 548194

Abstract:

Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.

US Patent:

6653304, Nov 25, 2003

Filed:

Feb 8, 2001

Appl. No.:

09/779109

Inventors:

Katerina Leftheris - Skillman NJ
Hong Wu - Lawrenceville NJ
Stephen Wrobleski - Whitehouse Station NJ
Ping Chen - Belle Mead NJ
John Hynes - Washington Crossing PA
John Tokarski - Princeton NJ

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

C07D40312

US Classification:

5142328, 514292, 544126, 546 81

Abstract:

Use of a compound for treating a respiratory disease in a mammal wherein the compound is a cannabinoid receptor modulator is disclosed. Compounds useful as cannabinoid receptor modulators for treating respiratory and non-respiratory leukocyte-activation associated diseases comprise compounds of formula (I), in which A and B are nitrogen or carbon, provided only one of A and B is nitrogen; and R -R are as defined in the specification, wherein R with R may form a ring, and/or two R groups may form a six-membered aryl or heteroaryl ring, optionally having a substituent R forming a ring with R.

US Patent:

6916809, Jul 12, 2005

Filed:

Dec 20, 2002

Appl. No.:

10/325009

Inventors:

Ping Chen - Belle Mead NJ, US
Edwin J. Iwanowicz - West Windsor NJ, US
Scott H. Watterson - Pennington NJ, US
Henry Gu - Bordentown NJ, US
Yufen Zhao - Pennington NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D471/14
C07D471/04
A61K031/4375
A61P019/02
A61P017/06

US Classification:

5142305, 51425505, 514256, 514293, 544105, 544333, 544405, 544 60, 544126, 544361, 544250, 546 81, 540575

Abstract:

Compounds having the formula (I), wherein Ris selected from H, OH and NH; Ris selected from ═O and ═S; W is —C(═O)—, —S(═O)—, or —S(O)—; or W may be —CH— if X is —C(═O)—; X is selected from —CH—, —N(R)—, and —O—, except that when W is —CH—, X is —C(═O)—; Y is a bond or —C(R)(R)—; Q is a linker; Z is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; and X, X, X, X, X, X, X, X, X, Xand Xare selected such a tricyclic heteroaryl ring system is formed as further defined in the specification.

US Patent:

6979694, Dec 27, 2005

Filed:

Mar 3, 2003

Appl. No.:

10/378372

Inventors:

Jagabandhu Das - Mercerville NJ, US
Ramesh Padmanabha - Hamden CT, US
Ping Chen - Belle Mead NJ, US
Derek J. Norris - Trenton NJ, US
Arthur M. P. Doweyko - Long Valley NJ, US
Joel C. Barrish - Holland PA, US
John Wityak - Robbinsville NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K031/426
A61K031/44
C07D277/20
C07D417/12

US Classification:

514342, 514371, 5462707, 548195, 544106, 544133

Abstract:

Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.

US Patent:

7064203, Jun 20, 2006

Filed:

Dec 22, 2004

Appl. No.:

11/019899

Inventors:

Ashvinikumar V. Gavai - Princeton Junction NJ, US
Wen-Ching Han - Newtown PA, US
Ping Chen - Belle Mead NJ, US
Edward H. Ruediger - Greenfield Park, CA
Harold Mastalerz - Guilford CT, US
Brian E. Fink - Princeton Junction NJ, US
Derek J. Norris - Pennington NJ, US

Assignee:

Bristol Myers Squibb Company - Princeton NJ

International Classification:

C07D 487/04
A61K 31/53
A61P 19/02

US Classification:

544183, 514243

Abstract:

The present invention provides compounds of formula IThe compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.

US Patent:

7091223, Aug 15, 2006

Filed:

Mar 3, 2003

Appl. No.:

10/378461

Inventors:

Jagabandhu Das - Mercerville NJ, US
Ramesh Padmanabha - Hamden CT, US
Ping Chen - Belle Mead NJ, US
Derek J. Norris - Trenton NJ, US
Arthur M. P. Doweyko - Long Valley NJ, US
Joel C. Barrish - Holland PA, US
John Wityak - Robbinsville NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/4439
C07D 417/12

US Classification:

514342, 5462707

Abstract:

Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.

US Patent:

7125875, Oct 24, 2006

Filed:

Mar 24, 2003

Appl. No.:

10/395503

Inventors:

Jagabandhu Das - Mercerville NJ, US
Ramesh Padmanabha - Hamden CT, US
Ping Chen - Belle Mead NJ, US
Derek J. Norris - Trenton NJ, US
Arthur M. P. Doweyko - Long Valley NJ, US
Joel C. Barrish - Richboro PA, US
John Wityak - Robbinsville NJ, US
Louis J. Lombardo - Belle Mead NJ, US
Francis Y. F. Lee - Yardley PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/427
A61K 31/496
A61K 31/501

US Classification:

51425219, 514370

Abstract:

Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.

US Patent:

7141571, Nov 28, 2006

Filed:

Dec 22, 2004

Appl. No.:

11/019901

Inventors:

Brian E. Fink - Princeton Junction NJ, US
Ashvinikumar V. Gavai - Princeton Junction NJ, US
Gregory D. Vite - Titusville NJ, US
Ping Chen - Belle Mead NJ, US
Harold Mastalerz - Guilford CT, US
Derek J. Norris - Pennington NJ, US
John S. Tokarski - Princeton NJ, US
Yufen Zhao - Pennington NJ, US
Wen-Ching Han - Newton PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 487/04
A61K 31/53

US Classification:

514243, 544183

Abstract:

The present invention provides compounds of formula IThe formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.