Ping Gao Li

US Patent:

7316907, Jan 8, 2008

Filed:

Sep 10, 2004

Appl. No.:

10/938387

Inventors:

Dihua Yu - Houston TX, US
Jun Yao - Chestnut Hill MA, US
Christopher L. Neal - Houston TX, US
Wentao Yang - Shanghai, CN
Xiaoyan Zhou - Shanghai, CN
Raphael E. Pollock - Houston TX, US
Mien-Chie Hung - Houston TX, US
Jun Yang - Houston TX, US
Ping Li - Houston TX, US
Nina T. Nguyen - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

G01N 33/53
G01N 33/574

US Classification:

435 71, 435 723

Abstract:

Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

US Patent:

7709205, May 4, 2010

Filed:

Dec 4, 2007

Appl. No.:

11/950264

Inventors:

Dihua Yu - Houston TX, US
Jun Yao - Chestnut Hill MA, US
Christopher L. Neal - Houston TX, US
Wentao Yang - Shanghai, CN
Xiaoyan Zhou - Shanghai, CN
Raphael E. Pollock - Houston TX, US
Mien-Chie Hung - Houston TX, US
Jun Yang - Houston TX, US
Ping Li - Houston TX, US
Nina T. Nguyen - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

US Patent:

20230077267, Mar 9, 2023

Filed:

Aug 20, 2021

Appl. No.:

17/408146

Inventors:

- Sunnyvale CA, US
Zhaozhuo XU - Houston TX, US
Weijie ZHAO - Sunnyvale CA, US
Zhixin ZHOU - Los Angeles CA, US
Ping LI - Bellevue WA, US

Assignee:

Baidu USA LLC - Sunnyvale CA

International Classification:

G06F 16/901
G06F 16/22

Abstract:

Incremental proximity graph maintenance (IPGM) systems and methods for online ANN search support both online vertex deletion and insertion of vertices on proximity graphs. In various embodiments, updating a proximity graph comprises receiving a workload that represents a set of vertices in the proximity graph, each vertex being associated with a type of operation such as a query, insertion, or deletion. For a query or an insertion, a search may be executed on the graph to obtain a set of top-K vertices for each vertex. In the case of a deletion, a vertex may be deleted from the proximity graph, and a local or global reconnection update method may be used to reconstruct at least a portion of the proximity graph.

US Patent:

20230035337, Feb 2, 2023

Filed:

Feb 18, 2022

Appl. No.:

17/676066

Inventors:

- Sunnyvale CA, US
Zhaozhuo XU - Houston TX, US
Weijie ZHAO - Sunnyvale CA, US
Hongliang FEI - Sunnyvale CA, US
Zhixin ZHOU - Los Angeles CA, US
Ping LI - Bellevue WA, US

Assignee:

Baidu USA LLC - Sunnyvale CA

International Classification:

G06F 16/901
G06F 16/22
G06F 17/16

Abstract:

Efficient inner product search is important for many data ranking services, such as recommendation and Information Retrieval. Efficient retrieval via inner product dramatically influences the performance of such data searching and retrieval systems. To resolve deficiencies of prior approaches, embodiments of a new index graph construction approach, referred to generally as Norm Adjusted Proximity Graph (NAPG), for approximate Maximum Inner Product Search (MIPS) are presented. With adjusting factors estimated on sampled data, NAPG embodiments select more meaningful data points to connect with when constructing a graph-based index for inner product search. Extensive experiments verify that the improved graph-based index pushes the state-of-the-art of inner product search forward greatly, in the trade-off between search efficiency and effectiveness.

US Patent:

20200197407, Jun 25, 2020

Filed:

Aug 10, 2018

Appl. No.:

16/638222

Inventors:

- Austin TX, US
Frank LOWERY - Houston TX, US
Chenyu ZHANG - Houston TX, US
Sunil ACHARYA - Houston TX, US
Ping LI - Houston TX, US

International Classification:

A61K 31/55
A61K 31/52
A61K 31/4025
A61K 31/454
A61K 31/427
A61K 31/4745
A61K 31/42
A61K 31/7105
A61K 31/4439
A61K 31/5377
A61P 35/04

Abstract:

Provided herein are methods for the treatment of brain metastasis by administering a kinase inhibitor targeted to a metastasis-promoting kinase identified by an in vivo kinase screen.

US Patent:

20170233755, Aug 17, 2017

Filed:

Apr 28, 2017

Appl. No.:

15/581870

Inventors:

- St. Louis MO, US
Pranesh BADAMI - Bangalore, IN
Amarjit BASRA - Chesterfield MO, US
Erin BELL - St. Louis MO, US
Christopher P. BONIN - Colchester CT, US
Paolo CASTIGLIONI - Davis CA, US
R. Eric CERNY - Chesterfield MO, US
Jaishree M. CHITTOOR - Wildwood MO, US
Paul CHOMET - St. Louis MO, US
Todd DEZWAAN - Apex NC, US
Stephen DUFF - St. Louis MO, US
Michael D. EDGERTON - St. Louis MO, US
Barry S. GOLDMAN - St. Louis MO, US
Kempagangaiah KRISHNAMURTHY - Bangalore, IN
Ping LI - St. Peters MO, US
Adrian A. LUND - Chesterfield MO, US
Linda LUTFIYYA - St. Louis MO, US
Thomas M. MALVAR - North Stonington CT, US
Donald E. NELSON - Durham NC, US
Dhanalakshmi RAMACHANDRA - Bangalore, IN
Thomas G. RUFF - Wildwood MO, US
Sara SALVADOR - Sudbury MA, US
S. SANGEETHA - Bangalore, IN
Char SHOBHA - Bangalore, IN
Jeffrey M. STAUB - WIldwood MO, US
Virginia URSIN - Pawcatuck CT, US
Tyamagondlu V. VENKATESH - St. Louis MO, US
Kammaradi R. VIDYA - Bangalore, IN
Xiaoyun WU - Chesterfield MO, US
Sean YANG - Chesterfield MO, US
Jianmin ZHAO - St. Louis MO, US

Assignee:

Monsanto Technology LLC - St. Louis MO

International Classification:

C12N 15/82
C12N 9/04

Abstract:

This disclosure provides transgenic plants having enhanced traits such as increased yield, increased nitrogen use efficiency and enhanced drought tolerance; propagules, progeny and field crops of such transgenic plants; and methods of making and using such transgenic plants. This disclosure also provides methods of producing hybrid seed from such transgenic plants, growing such seed and selecting progeny plants with enhanced traits. Also disclosed are transgenic plants with altered phenotypes which are useful for screening and selecting transgenic events for the desired enhanced trait.

US Patent:

20150096083, Apr 2, 2015

Filed:

Jul 28, 2014

Appl. No.:

14/444966

Inventors:

- St. Louis MO, US
Qi Wang - St. Louis MO, US
James Morrell - St. Louis MO, US
Linda Lutfiyya - St. Louis MO, US
Maolong Lu - St. Louis MO, US
Zhaolong Li - St. Charles MO, US
Ping Li - St. Peters MO, US
Michelle Lacy - St. Louis MO, US
David Kovalic - Clayton MO, US
Yongwei Cao - Chesterfield MO, US
Andrey Boukharov - Melrose MA, US
Stanislaw Flasinski - Chesterfield MO, US
Peter T. Hajdukiewicz - Chesterfield MO, US

International Classification:

C12N 15/82
A01N 57/20

US Classification:

800302, 435419, 800298, 435412, 8003203, 8003201, 8003202, 800320, 435414, 435411, 435415, 435417, 435416, 8003173, 8003174, 8003172, 800312, 800314, 800306, 800322, 536 236, 504206

Abstract:

The present invention provides non-coding regulatory element polynucleotide molecules isolated from the lipid transfer protein (LTP) gene of and useful for expressing transgenes in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the regulatory polynucleotide sequences, and methods for preparing and using the same.

US Patent:

20150089683, Mar 26, 2015

Filed:

Mar 6, 2013

Appl. No.:

14/395636

Inventors:

- St. Louis MO, US
Pranesh Badami - Bangalore, IN
Amarjit Basra - Chesterfield MO, US
Erin Bell - St. Louis MO, US
Christopher P. Bonin - Colchester CT, US
Paolo Castiglioni - Davis CA, US
Eric R. Cerny - Chesterfield MO, US
Paul Chomet - St. Louis MO, US
Todd Dezwaan - Apex NC, US
Stephen Duff - St. Louis MO, US
Michael D. Edgerton - St. Louis MO, US
Barry S. Goldman - St. Louis MO, US
Kempagangaiah Krishnamurthy - Bangalore, IN
Ping Li - St. Peters MO, US
Adrian A. Lund - Chesterfield MO, US
Llinda Lutfiyya - St. Louis MO, US
Thomas M. Malvar - North Stonington CT, US
Donald E. Nelson - Durham NC, US
Dhanalakshmi Ramachandra - Bangalore, IN
Thomas G. Ruff - Wildwood MO, US
Sara Salvador - Sudbury MA, US
S. Sangeetha - Bangalore, IN
Char Shobha - Bangalore, IN
Jeffrey M. Staub - Wildwood MO, US
Virginia Ursin - Pawcatuck CT, US
Tyamagondlu V. Venkatesh - St. Louis MO, US
Kammaradi R. Vidya - Bangalore, IN
Xiaoyun Wu - Chesterfield MO, US
Sean Yang - Chesterfield MO, US
Jianmin Zhao - St. Louis MO, US

International Classification:

C12N 15/82
C12N 5/04
A01H 1/02

US Classification:

800260, 800298, 800320, 8003203, 8003201, 8003202, 800322, 800305, 800306, 800309, 800310, 800307, 800308, 800313, 800312, 800314, 800315, 800316, 800317, 8003172, 8003174, 8003171, 8003173, 800319, 435419, 800278, 800290

Abstract:

This disclosure provides transgenic plants having enhanced traits such as increased yield, increased nitrogen use efficiency and enhanced drought tolerance; propagules, progeny and field crops of such transgenic plants; and methods of making and using such transgenic plants. This disclosure also provides methods of producing hybrid seed from such transgenic plants, growing such seed and selecting progeny plants with enhanced traits. Also disclosed are transgenic plants with altered phenotypes which are useful for screening and selecting transgenic events for the desired enhanced trait.