Poothappillai K Kasinathan from Brier, WA, age 68

Transgenic Bovines Capable Of Human Antibody Production
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US Patent:

7414170, Aug 19, 2008
Filed:

May 19, 2003
Appl. No.:

10/441503
Inventors:

James M. Robl - Brandon SD, US
Poothappillai Kasinathan - Sioux Falls SD, US
Richard A. Goldsby - Leverett MA, US
Yoshimi Kuroiwa - Sioux Falls SD, US
Kazuma Tomizuka - Takasaki, JP
Isao Ishida - Isehara, JP
Barbara Osborne - Leverett MA, US
Assignee:

Kirin Beer Kabushiki Kaisha - Tokyo
International Classification:

A01K 67/027
C12P 21/00
C12N 15/00
US Classification:

800 15, 800 5, 800 6, 800 25
Abstract:

The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e. g. , non-bovine antibodies), preferably human antibodies.

Transgenic Animals And Uses Thereof
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US Patent:

7420099, Sep 2, 2008
Filed:

Apr 21, 2005
Appl. No.:

11/111310
Inventors:

James M. Robl - Brandon SD, US
Yoshimi Kuroiwa - Sioux Falls SD, US
Poothappillai Kasinathan - Sioux Falls SD, US
Isao Ishida - Isehara, JP
Kazuma Tomizuka - Takasaki, JP
Assignee:

Kirin Holdings Kabushiki Kaisha - Tokyo
International Classification:

A01K 67/027
C12P 21/00
C12N 15/00
US Classification:

800 15, 800 6, 800 25
Abstract:

In general, the invention features genetically modified non-human mammals (e. g. , bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.

Transgenic Ungulates Capable Of Human Antibody Production
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US Patent:

7803981, Sep 28, 2010
Filed:

Jun 20, 2007
Appl. No.:

11/820768
Inventors:

James M. Robl - Brandon SD, US
Philippe Collas - Oslo, NO
Eddie Sullivan - Tea SD, US
Poothappillai Kasinathan - Sioux Falls SD, US
Richard A. Goldsby - Leverett MA, US
Yoshimi Kuroiwa - Sioux Falls SD, US
Kazuma Tomizuka - Takasaki, JP
Isao Ishida - Isehara, JP
Barbara Osborne - Leverett MA, US
Assignee:

Kyowa Hakko Kirin Co., Ltd. - Tokyo
International Classification:

C12P 33/00
A01K 67/027
C12N 5/00
US Classification:

800 15, 800 4, 800 5, 800 16, 800 17, 435325
Abstract:

The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e. g. , non-bovine antibodies), preferably human antibodies.

Method Of Producing Xenogenous Antibodies Using A Bovine
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US Patent:

7928285, Apr 19, 2011
Filed:

Jun 25, 2008
Appl. No.:

12/215085
Inventors:

James M. Robl - Brandon SD, US
Yoshimi Kuroiwa - Sioux Falls SD, US
Poothappillai Kasinathan - Sioux Falls SD, US
Isao Ishida - Isehara, JP
Kazuma Tomizuka - Takasaki, JP
Assignee:

Kyowa Hakko Kirin Co., Ltd. - Tokyo
International Classification:

A01K 67/00
A01K 67/027
A01K 67/033
C12P 21/00
C12N 15/00
US Classification:

800 4, 800 15, 800 5, 800 6, 800 7, 800 8, 800 14, 800 21
Abstract:

In general, the invention features genetically modified non-human mammals (e. g. , bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.

Transgenic Animals And Uses Thereof
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US Patent:

20110231943, Sep 22, 2011
Filed:

Apr 6, 2011
Appl. No.:

13/080923
Inventors:

JAMES M. ROBL - BRANDON SD, US
YOSHIMI KUROIWA - SIOUX FALLS SD, US
POOTHAPPILLAI KASINATHAN - SIOUX FALLS SD, US
ISAO ISHIDA - ISEHARA, JP
KAZUMA TOMIZUKA - TAKASAKI, JP
Assignee:

KYOWA HAKKO KIRIN CO., LTD. - TOKYO
International Classification:

A01K 67/027
US Classification:

800 15, 800 14, 800 17, 800 16
Abstract:

In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.

Methods For Cloning Non-Human Mammals Using Reprogrammed Donor Chromatin Or Donor Cells
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US Patent:

7253334, Aug 7, 2007
Filed:

Dec 21, 2001
Appl. No.:

10/032191
Inventors:

Philippe Collas - Oslo, NO
James M. Robl - Belchertown MA, US
Eddie Sullivan - Manhattan KS, US
Poothappillai Kasinathan - Brandon SD, US
Assignee:

Aurox, LLC - Westport CT
International Classification:

C12N 15/00
G01N 33/00
C12P 21/00
A01K 67/00
US Classification:

800 24, 800 3, 800 4, 800 8, 800 21, 800 25, 435325
Abstract:

The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features methods of inserting chromosomes or nuclei into recipient cells.

Poothappillai K Kasinathan