Pradipta Ghosh

US Patent:

20210239686, Aug 5, 2021

Filed:

May 13, 2019

Appl. No.:

17/051293

Inventors:

- Oakland CA, US
Pradipta Ghosh - San Diego CA, US

International Classification:

G01N 33/542
G01N 33/574

Abstract:

The present invention provides a Fluorescence Resonance Energy Transfer (FRET) biosensor that measures the metastatic potential and/or chemoresistance of single living cancer cells, and/or cells associated with fibrogenesis, diabetes, aging, and/or infertility.

US Patent:

20200064352, Feb 27, 2020

Filed:

Feb 22, 2018

Appl. No.:

16/487462

Inventors:

- Oakland CA, US
Pradipta Ghosh - San Diego CA, US

International Classification:

G01N 33/68
C07K 14/47
C07K 7/08
C07K 14/72
A61K 31/185

Abstract:

Research tool assay for identifying a specific modulator of GNAI, compositions and methods of use. The assay includes combining a drug candidate with GNAI and a C-terminal GIV peptide and determining if the drug candidate inhibits GNAI interaction with the C-terminal GIV peptide; and combining the drug candidate with GNAI and a DAPLE peptide and determining if the drug candidate inhibits GNAI interaction with DAPLE peptide. Also provided are compositions and methods of treatment relating to the same.

US Patent:

20180104307, Apr 19, 2018

Filed:

Apr 15, 2016

Appl. No.:

15/565192

Inventors:

Pradipta GHOSH - San Diego CA, US
- Oakland CA, US
Pradipta Ghosh - San Diego CA, US

International Classification:

A61K 38/17
C07K 14/005
C07K 19/00
C12N 15/63
C07K 14/47
A61P 35/04

Abstract:

The invention provides cell-permeable Ga-Interacting Vesicle associated protein (GIV)-derived peptides and their use for treatment of diverse diseases. The invention further provides C-terminus of Ga-Interacting Vesicle associated protein (GIV-CT)-based peptides and GIV-CT encoding vectors and methods of use thereof, for successfully manipulating the diverse pathophysiologic processes in which GIV has been implicated. In one aspect, the invention provides cell-permeable peptides PTD-GIV-CT comprising (i) a peptide transduction domain (PTD) and (ii) a C-terminus of Ga-Interacting Vesicle associated protein (GIV-CT) or a mutant thereof. In one embodiment, said peptides are capable of activating Gi ownstream of receptor tyrosine kinases (RTKs). The invention also provides pharmaceutical compositions comprising one or more of the peptides of the invention as well as vectors encoding such peptides.

US Patent:

20160362464, Dec 15, 2016

Filed:

Jun 9, 2016

Appl. No.:

15/178480

Inventors:

- Oakland CA, US
Pradipta Ghosh - San Diego CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07K 14/47
C07K 16/18
C12Q 1/68
C12N 15/113

Abstract:

The invention provides DAPLE as a novel regulator of G protein activity and its diagnostic and therapeutic use in cancer.

US Patent:

20140234872, Aug 21, 2014

Filed:

Jul 25, 2012

Appl. No.:

14/235036

Inventors:

Pradipta Ghosh - San Diego CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33/574
C07K 16/18

US Classification:

435 792, 5303879, 5303913, 435 71

Abstract:

The present disclosure generally relates to tyrosine phosphorylation sites of an Akt enhancer, and methods for the detection of the phosphorylated tyrosine residues. In particular, anti-phosphotyrosine antibodies and binding proteins find use in the compositions and methods of the present disclosure.