Qing L Li

US Patent:

7407765, Aug 5, 2008

Filed:

Jan 26, 2006

Appl. No.:

11/339553

Inventors:

Xiaodong Li - Oceanside CA, US
Hong Xu - San Diego CA, US
Huixian Tang - San Diego CA, US
Qing Li - San Diego CA, US

Assignee:

Senomyx, Inc. - La Jolla CA

International Classification:

G01N 33/566
C07K 14/705

US Classification:

435 71, 435 72, 435 721, 436501

Abstract:

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i. e. , acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.

US Patent:

7883856, Feb 8, 2011

Filed:

Jun 22, 2007

Appl. No.:

11/766974

Inventors:

Xiaodong Li - San Diego CA, US
Hong Xu - San Diego CA, US
Qing Li - San Diego CA, US
Huixian Tang - San Diego CA, US
Alexey Pronin - San Diego CA, US

Assignee:

Senomyx Inc. - San Diego CA

International Classification:

G01N 33/566
C07K 14/705

US Classification:

435 71, 435 72, 435 721, 436501

Abstract:

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste. Also T2R ligands may be used as therapeutics to treat and modulate T2R associated gastrointestinal and metabolic functions as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.

US Patent:

7906627, Mar 15, 2011

Filed:

Oct 19, 2006

Appl. No.:

11/583097

Inventors:

Xiaodong Li - San Diego CA, US
Feng Zhang - San Diego CA, US
Hong Xu - San Diego CA, US
Qing Li - San Diego CA, US

Assignee:

Senomyx, Inc. - San Diego CA

International Classification:

C07K 1/00
C07K 14/00
C07K 16/00
C07K 17/00
C08H 1/00
C07H 21/04
C12P 21/06
C12N 1/20
C12N 15/00
C12N 5/00
C12N 5/02
C12N 15/74

US Classification:

530402, 435 691, 4352523, 4353201, 435325, 435471, 530350, 536 235

Abstract:

This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.

US Patent:

7915003, Mar 29, 2011

Filed:

Jul 2, 2008

Appl. No.:

12/166980

Inventors:

Xiaodong Li - Oceanside CA, US
Hong Xu - San Diego CA, US
Huixian Tang - San Diego CA, US
Qing Li - San Diego CA, US

Assignee:

Senomyx, Inc. - San Diego CA

International Classification:

G01N 33/566
C07K 14/705

US Classification:

435 72, 435 71, 435 721, 436501

Abstract:

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i. e. , acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.

US Patent:

7939276, May 10, 2011

Filed:

Jun 20, 2006

Appl. No.:

11/455693

Inventors:

Xiaodong Li - San Diego CA, US
Hong Xu - San Diego CA, US
Qing Li - Draper UT, US
Huixian Tang - San Diego CA, US

Assignee:

Senomyx, Inc. - San Diego CA

International Classification:

G01N 33/567
C07K 14/705

US Classification:

435 721, 530350, 738657, 514974

Abstract:

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds, i. e. , chlorogenic lactone compounds that contribute at least partially to the bitter taste of many coffee beverages. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by chlorogenic lactones and related compounds and which may be used as additives and/or removed from foods, beverages and medicinals in order to modify (block) T2R-associated bitter taste. A preferred embodiment is the use of the identified compounds as additives in coffee and coffee-flavored foods, beverages and medicinals.

US Patent:

7939671, May 10, 2011

Filed:

Aug 19, 2008

Appl. No.:

12/222918

Inventors:

Xiaodong Li - San Diego CA, US
Andrew Patron - San Marcos CA, US
Catherine Tachdjian - San Diego CA, US
Hong Xu - San Diego CA, US
Qing Li - San Diego CA, US
Alexey Pronin - San Diego CA, US
Guy Servant - San Diego CA, US
Lan Zhang - San Diego CA, US
Thomas Brady - San Diego CA, US
Vincent Darmohusodo - San Diego CA, US
Melissa Arellano - San Diego CA, US
Victor Selchau - San Diego CA, US
Brett Weylan Ching - San Diego CA, US
Donald S. Karanewsky - Escondido CA, US
Paul Brust - San Diego CA, US
Jing Ling - Carlsbad CA, US
Wen Zhao - San Diego CA, US
Chad Priest - Encinitas CA, US

Assignee:

Senomyx, Inc. - San Diego CA

International Classification:

C07D 261/08
C07D 413/14
A61K 31/44
A61K 31/42

US Classification:

548247, 5462721, 514341, 514378

Abstract:

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e. g. , coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e. g. , coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

US Patent:

8030008, Oct 4, 2011

Filed:

Nov 1, 2006

Appl. No.:

11/555617

Inventors:

Xiaodong Li - San Diego CA, US
Hong Xu - San Diego CA, US
Qing Li - San Diego CA, US
Huixian Tang - San Diego CA, US
Alexey Pronin - San Diego CA, US

Assignee:

Senomyx, Inc. - San Diego CA

International Classification:

G01N 33/567
C07K 14/705

US Classification:

435 72, 435 721, 436501

Abstract:

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. The invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by these bitter ligands and related compounds and which may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste.

US Patent:

8148544, Apr 3, 2012

Filed:

Mar 18, 2011

Appl. No.:

13/051052

Inventors:

Xiaodong Li - San Diego CA, US
Andrew Patron - San Marcos CA, US
Catherine Tachdjian - San Diego CA, US
Hong Xu - San Diego CA, US
Qing Li - San Diego CA, US
Alexey Pronin - San Diego CA, US
Guy Servant - San Diego CA, US
Lan Zhang - San Diego CA, US
Thomas Brady - San Diego CA, US
Vincent Darmohusodo - San Diego CA, US
Melissa Arellano - San Diego CA, US
Victor Selchau - San Diego CA, US
Brett Weylan Ching - San Diego CA, US
Donald S. Karanewsky - Escondido CA, US
Paul Brust - San Diego CA, US
Jing Ling - Carlsbad CA, US
Wen Zhao - San Diego CA, US
Chad Priest - Encinitas CA, US

Assignee:

Senomyx, Inc. - San Diego CA

International Classification:

C07D 261/06

US Classification:

548247

Abstract:

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e. g. , coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e. g. , coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.