Qing M Lin

US Patent:

8586707, Nov 19, 2013

Filed:

Sep 16, 2009

Appl. No.:

12/561107

Inventors:

Qing Lin - Getzville NY, US
Mike Madden - N. Tonawanda NY, US

Assignee:

The Research Foundation of State University of New York - Amherst NY

International Classification:

A61K 38/00
A61K 38/04
C07K 5/00
C07K 7/00
C07K 16/00
C07K 17/00

US Classification:

530333, 530329, 530327, 530300, 514 11

Abstract:

A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.

US Patent:

20080305519, Dec 11, 2008

Filed:

Feb 23, 2007

Appl. No.:

11/709949

Inventors:

Qing Lin - Getzville NY, US
Michael M. Madden - Buffalo NY, US

International Classification:

C12P 21/06
C07K 7/00
C07D 235/02

US Classification:

435 681, 530300, 5483041, 530329, 530330, 530331

Abstract:

An improved method for protein labeling comprising the steps of providing a synthetic small molecule tag, providing a target protein to be tagged, providing at least two enzymes for catalyzing a conjugation reaction between the tag and the target protein, incubating the tag, the protein and the enzyme, and allowing the tag to conjugate to the target protein. The tag may embody at least one structural feature of an ubiquitin C-terminus, and the structural feature may comprise a recognition sequence that is recognizable by an ubiquitin activating enzyme.

US Patent:

20140057857, Feb 27, 2014

Filed:

Dec 15, 2011

Appl. No.:

13/994296

Inventors:

Qing Lin - Getzville NY, US
Avinash Muppidi - Buffalo NY, US

Assignee:

The Research Foundation for the State University of New York - Amherst NY

International Classification:

C07K 7/56

US Classification:

514 211, 530317

Abstract:

Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide.