Klarisa Rikova - Reading MA, US Roberto Polakiewicz - Lexington MA, US Ailan Guo - Lexington MA, US Katherine Eleanor Crosby - Middleton MA, US Qingfu Zeng - Hamilton MA, US Kimberly A Lee - Seattle WA, US
Assignee:
Cell Signaling Technology, Inc. - Danvers MA
International Classification:
A01N 43/54 G01N 33/574 C12Q 1/68
US Classification:
514256, 435 723, 435 614, 514247
Abstract:
The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFRα) is expressed and is driving the disease, and provides methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFRα is expressed, and for identifying a NSCLC tumor that is likely to respond to a PDGFRα-inhibiting therapeutic. The invention also provides methods for inhibiting the progression of a mammalian NSCLC tumor in which PDGFRα is expressed, and for determining whether a compound inhibits the progression of a PDGFRα-expressing mammalian NSCLC tumor.
Identification Of Non-Small Cell Lung Carcinoma (Nsclc) Tumors Expressing Pdgfr-Alpha
Klarisa Rikova - Reading MA, US Roberto Polakiewicz - Lexington MA, US Ailan Guo - Burlington MA, US Katherine Crosby - Middleton MA, US Qingfu Zeng - Hamilton MA, US Kimberly Lee - Boston MA, US
International Classification:
G01N 33/574 A61K 31/506
US Classification:
435007230, 514252180
Abstract:
The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFRα) is expressed and is driving the disease, and provides methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFRα is expressed, and for identifying a NSCLC tumor that is likely to respond to a PDGFRα-inhibiting therapeutic. The invention also provides methods for inhibiting the progression of a mammalian NSCLC tumor in which PDGFRα is expressed, and for determining whether a compound inhibits the progression of a PDGFRα-expressing mammalian NSCLC tumor.