Qun Zhou

US Patent:

7700321, Apr 20, 2010

Filed:

Oct 20, 2006

Appl. No.:

11/551679

Inventors:

John M. McPherson - Hopkinton MA, US
Tim Edmunds - Bolton MA, US
Qun Zhou - Ashland MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

C12P 21/08

US Classification:

435 7021

Abstract:

Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases.

US Patent:

8071336, Dec 6, 2011

Filed:

Feb 12, 2010

Appl. No.:

12/704990

Inventors:

John M. McPherson - Hopkinton MA, US
Tim Edmunds - Bolton MA, US
Qun Zhou - Ashland MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

C12P 21/08

US Classification:

435 7021

Abstract:

Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases.

US Patent:

20110300120, Dec 8, 2011

Filed:

Dec 11, 2009

Appl. No.:

13/140272

Inventors:

Luis Z. Avila - Arlington MA, US
Clark Q. Pan - Sudbury MA, US
Patrick Finn - Weymouth MA, US
John Harrahy - Medway MA, US
Qun Zhou - Ashland MA, US
Yunxiang Zhu - Wayland MA, US
Paul A. Konowicz - Maynard MA, US
Duncan E. Paterson - Zurich, CH
Andreas Peer - Basel, CH
Joseph P. Kutzko - Southborough MA, US
Michael R. Reardon - North Attleboro MA, US
James E. Stefano - Hopkinton MA, US
Xiaoyang Zheng - Newton MA, US
Robert J. Miller - E. Bridgewater MA, US
Lauren Young - Hampton NH, US

International Classification:

A61K 38/43
C12N 9/96
A61P 3/00
C07H 1/00
C08B 37/00
C07K 2/00
A61K 38/02

US Classification:

424 943, 530395, 435188, 514 209, 536 171, 536 182

Abstract:

Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

US Patent:

20220242899, Aug 4, 2022

Filed:

Feb 14, 2022

Appl. No.:

17/671249

Inventors:

- Cambridge MA, US
Clark Q. PAN - Sudbury MA, US
Patrick FINN - Weymouth MA, US
John HARRAHY - Medway MA, US
Qun ZHOU - Ashland MA, US
Yunxiang ZHU - Wayland MA, US
Paul A. KONOWICZ - Maynard MA, US
Duncan E. PATERSON - Zurich, CH
Andreas PEER - Basel, CH
Joseph P. KUTZKO - Southborough MA, US
Michael R. REARDON - North Attleboro MA, US
James E. STEFANO - Hopkinton MA, US
Xiaoyang ZHENG - Newton MA, US
Robert J. MILLER - E. Bridgewater MA, US
Lauren YOUNG - Hampton NH, US

International Classification:

C07H 15/04
A61K 47/61

Abstract:

Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

US Patent:

20200216485, Jul 9, 2020

Filed:

Sep 24, 2019

Appl. No.:

16/581148

Inventors:

- Cambridge MA, US
Clark Q. PAN - Sudbury MA, US
Patrick FINN - Weymouth MA, US
John HARRAHY - Medway MA, US
Qun ZHOU - Ashland MA, US
Yunxiang ZHU - Wayland MA, US
Paul A. KONOWICZ - Maynard MA, US
Duncan E. PATERSON - Zurich, CH
Andreas PEER - Basel, CH
Joseph P. KUTZKO - Southborough MA, US
Michael R. REARDON - North Attleboro MA, US
James E. STEFANO - Hopkinton MA, US
Xiaoyang ZHENG - Newton MA, US
Robert J. MILLER - E. Bridgewater MA, US
Lauren YOUNG - Hampton NH, US

International Classification:

C07H 15/04
A61K 47/61

Abstract:

Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

US Patent:

20190233531, Aug 1, 2019

Filed:

Jan 3, 2019

Appl. No.:

16/238932

Inventors:

- Cambridge MA, US
Qun Zhou - Ashland MA, US
James Stefano - Hopkinton MA, US
Pradeep Dhal - Westford MA, US
Bo Chen - Boston MA, US
Diego Gianolio - Somerville MA, US
Robert Miller - East Bridgewater MA, US
Huawei Qiu - Westborough MA, US

International Classification:

C07K 16/28
C07K 16/40
A61K 47/54
A61K 47/68
C07K 16/32

Abstract:

The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

US Patent:

20190060481, Feb 28, 2019

Filed:

Aug 6, 2018

Appl. No.:

16/055661

Inventors:

- Cambridge MA, US
Qun Zhou - Ashland MA, US

International Classification:

A61K 47/68
A61K 47/54
C07K 16/40
C07K 16/28
C07K 16/32
A61K 39/00

Abstract:

The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

US Patent:

20180002365, Jan 4, 2018

Filed:

Oct 7, 2016

Appl. No.:

15/288486

Inventors:

- Cambridge MA, US
Clark Q. PAN - Sudbury MA, US
Patrick FINN - Weymouth MA, US
John HARRAHY - Medway MA, US
Qun ZHOU - Ashland MA, US
Yunxiang ZHU - Wayland MA, US
Paul A. KONOWICZ - Maynard MA, US
Duncan E. PATERSON - Zurich, CH
Andreas PEER - Basel, CH
Joseph P. KUTZKO - Southborough MA, US
Michael R. REARDON - North Attleboro MA, US
James E. STEFANO - Hopkinton MA, US
Xiaoyang ZHENG - Newton MA, US
Robert J. MILLER - E. Bridgewater MA, US
Lauren YOUNG - Hampton NH, US

International Classification:

C07H 15/04
A61K 47/61

Abstract:

Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.