Ralph B Robinson

US Patent:

6380219, Apr 30, 2002

Filed:

Aug 8, 2000

Appl. No.:

09/635186

Inventors:

Ralph P. Robinson - Gales Ferry CT
James P. Rizzi - Niwot CO

Assignee:

Pfizer Inc - New York NY

International Classification:

A61K 314468

US Classification:

514329, 546223, 562430, 562622

Abstract:

A compound of the formula wherein n, X, R , R and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF.

US Patent:

6458822, Oct 1, 2002

Filed:

Dec 5, 2000

Appl. No.:

09/730302

Inventors:

Ralph P. Robinson - Gales Ferry CT
Ellen R. Laird - Mystic CT

Assignee:

Pfizer Inc. - New York NY

International Classification:

A61K 314166

US Classification:

514401, 5483335

Abstract:

The present invention relates to a compound of the formula wherein R , R , R and R are as defined above, and pharmaceutically acceptable salts and solvates thereof, that are useful, for example, as matrix metalloproteinase inhibitors. The present invention is also directed to pharmaceutical compositions comprising such compounds and methods of treatment for diseases such as osteoarthritis, rheumatoid arthritis, cancer, osteoporosis, tissue ulceration, restinosis, periodontal disease, inflammation, epidermolysis bullosa, scleritis, stroke, Alzheimers disease, and the like, characterized by inappropriate matrix metalloproteinase activity. Processes for the synthesis of compounds of formula (I) are also disclosed.

US Patent:

6852719, Feb 8, 2005

Filed:

Oct 26, 2001

Appl. No.:

10/012274

Inventors:

Kevin K. Liu - East Lyme CT, US
Bradley P. Morgan - Lyme CT, US
Ralph P. Robinson - Gales Ferry CT, US

Assignee:

Pfizer Inc. - New York NY
Pfizer Products, Inc. - Groton CT

International Classification:

A61K031/4245
C07D271/06

US Classification:

5142362, 514326, 514340, 514364, 544138, 546209, 5462691, 548131

Abstract:

The present invention provides non-steroidal compounds of Formula I, including prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e. g. , agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides processes for preparing these compounds.

US Patent:

7138406, Nov 21, 2006

Filed:

Jul 8, 2003

Appl. No.:

10/615126

Inventors:

Yves A. Chantigny - Groton CT, US
Edward F. Kleinman - Pawcatuck CT, US
Ralph P. Robinson - Gales Ferry CT, US

Assignee:

Pfizer, Inc. - New York NY
Pfizer Products, Inc. - Groton CT

International Classification:

A61K 31/435
A61K 31/44
C07D 211/04

US Classification:

514277, 514332, 514364, 514365, 546266, 546285, 548131, 548203, 564172, 560 5

Abstract:

The present invention provides compounds of the formula.

US Patent:

7368573, May 6, 2008

Filed:

Jun 15, 2006

Appl. No.:

11/424488

Inventors:

Peter Bertinato - Old Lyme CT, US
Michel A. Couturier - Pawcatuck CT, US
Ernest S. Hamanaka - Gales Ferry CT, US
Marcus D. Ewing - Colchester CT, US
Ralph P. Robinson - Gales Ferry CT, US
Derek L. Tickner - Waterford CT, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D 215/38
C07D 215/46
A61K 31/47

US Classification:

546162, 546163, 514313

Abstract:

This invention relates to MTP/Apo-B secretion inhibitors of Formula (I).

US Patent:

7393958, Jul 1, 2008

Filed:

Oct 30, 2006

Appl. No.:

11/554351

Inventors:

Peter Bertinato - Old Lyme CT, US
Michel A. Couturier - Pawcatuck CT, US
Ernest S. Hamanaka - Gales Ferry CT, US
Marcus D. Ewing - Colchester CT, US
Ralph P. Robinson - Gales Ferry CT, US
Derek L. Tickner - Waterford CT, US

Assignee:

Pfizer, Inc. - New York NY

International Classification:

C07D 215/38
A61K 31/47

US Classification:

546156, 514312

Abstract:

This invention relates to MTP/Apo-B secretion inhibitors of Formula (I).

US Patent:

7468378, Dec 23, 2008

Filed:

Feb 3, 2005

Appl. No.:

11/049852

Inventors:

Peter Bertinato - Old Lyme CT, US
Michel A. Couturier - Pawcatuck CT, US
Ernest S. Hamanaka - Gales Ferry CT, US
Marcus D. Ewing - Colchester CT, US
Ralph P. Robinson - Gales Ferry CT, US
Derek L. Tickner - Waterford CT, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

A61K 31/44
C07D 275/04

US Classification:

514312, 546156

Abstract:

This invention relates to MTP/Apo-B secretion inhibitors of Formula (I).

US Patent:

7553877, Jun 30, 2009

Filed:

Jul 13, 2006

Appl. No.:

11/457323

Inventors:

Yves A. Chantigny - Pincourt, CA
Edward F. Kleinman - Pawcatuck CT, US
Ralph P. Robinson - Gales Ferry CT, US

Assignee:

Pfizer, Inc. - New York NY

International Classification:

A61K 31/56
A61K 31/015

US Classification:

514765, 514169, 514171, 514762, 514763, 514764

Abstract:

The present invention provides compounds of the formula.