Ram B Gupta

US Patent:

6620351, Sep 16, 2003

Filed:

May 16, 2001

Appl. No.:

09/858301

Inventors:

Ram B. Gupta - Auburn AL
Pratibhash Chattopadhyay - Auburn AL

Assignee:

Auburn University - Auburn AL

International Classification:

B29B 900

US Classification:

264 7, 264 9

Abstract:

The current invention, Supercritical Antisolvent Precipitation with Enhanced Mass Transfer (SAS-EM) provides a significantly improved method for the production of nano and micro-particles with a narrow size distribution. The processes of the invention utilize the properties of supercritical fluids and also the principles of virbrational atomization to provide an efficient technique for the effective nanonization or micronization of particles. Like the SAS technique, SAS-EM, also uses a supercritical fluid as the antisolvent, but in the present invention the dispersion jet is deflected by a vibrating surface that atomizes the jet into fine droplets. The vibrating surface also generates a vibrational flow field within the supercritical phase that enhances mass transfer through increased mixing. Sizes of the particles obtained by this technique are easily controlled by changing the vibration intensity of the deflecting surface, which in turn is controlled by adjusting the power input to the vibration source. A major advantage of the SAS-EM technique is that it can be successfully used to obtain nanoparticles of materials that usually yield fibers or large crystals in SAS method.

US Patent:

8637718, Jan 28, 2014

Filed:

Sep 3, 2010

Appl. No.:

12/875549

Inventors:

Ram B. Gupta - Auburn AL, US
Sandeep Kumar - Auburn AL, US
Lingzhao Kong - Auburn AL, US

Assignee:

Auburn University - Auburn AL

International Classification:

C07C 1/00

US Classification:

585242, 202 96, 202117, 202118, 210749, 210761, 210774

Abstract:

A method and system of converting biomass to biochar in a hydrothermal carbonization apparatus wherein subcritical water at a temperature of 230-350 C. and 500-3000 psi is reacted with the biomass to form biochar, biocrude and gases. The method and system include recycling the biocrude back to the hydrothermal carbonization apparatus which improves biochar yield and provides water for the biomass reaction to occur.

US Patent:

20040026804, Feb 12, 2004

Filed:

Jun 16, 2003

Appl. No.:

10/461459

Inventors:

Ram Gupta - Auburn AL, US
Pratibhash Chattopadhyay - North Royalton OH, US

Assignee:

Auburn University - Auburn AL

International Classification:

B29B009/00

US Classification:

264/007000, 264/009000, 264/407000, 425/006000, 425/174400

Abstract:

The current invention, Supercritical Antisolvent Precipitation with Enhanced Mass Transfer (SAS-EM) provides a significantly improved method for the production of nano and micro-particles with a narrow size distribution. The processes of the invention utilize the properties of supercritical fluids and also the principles of virbrational atomization to provide an efficient technique for the effective nanonization or micronization of particles. Like the SAS technique, SAS-EM, also uses a supercritical fluid as the antisolvent, but in the present invention the dispersion jet is deflected by a vibrating surface that atomizes the jet into fine droplets. The vibrating surface also generates a vibrational flow field within the supercritical phase that enhances mass transfer through increased mixing. Sizes of the particles obtained by this technique are easily controlled by changing the vibration intensity of the deflecting surface, which in turn is controlled by adjusting the power input to the vibration source. A major advantage of the SAS-EM technique is that it can be successfully used to obtain nanoparticles of materials that usually yield fibers or large crystals in SAS method. Microencapsulation via coprecipitation of two or more materials can also be achieved using the SAS-EM technique.

US Patent:

20220410112, Dec 29, 2022

Filed:

Nov 27, 2020

Appl. No.:

17/780459

Inventors:

- Richmond VA, US
Ram B. Gupta - Richmond VA, US

International Classification:

B01J 19/00
C01G 53/00

Abstract:

Slug flow manufacturing systems and methods for production of battery microparticle materials such as nickel-cobalt-manganese oxide (NCM) are disclosed. The slug flow reactor system is capable of producing microparticles reproducibly and continuously in desired scales. The system may be run with fast kinetics (e.g., complete reaction from nucleation to particle recovery completes within a few minutes) and near-ambient reaction temperature (e.g., allowing to use inexpensive plastic tubing). The system allows control of composition (overall, and radial profile) and size of microparticles without changing chemistry nor increasing temperature. The platforms offers the ability to conveniently generate uniform microparticles, of controllable size with an ease of scale up.

US Patent:

20190209679, Jul 11, 2019

Filed:

Mar 15, 2019

Appl. No.:

16/355057

Inventors:

- Auburn AL, US
Ram B. Gupta - Auburn AL, US
Erfan U. Chowdhury - Auburn AL, US
Courtney A. Ober - Carlisle PA, US

Assignee:

Auburn University - Auburn AL

International Classification:

A61K 39/39
A61K 9/16
A61K 47/10
A61K 31/47
A61K 39/118
A61K 31/472
A61K 9/00
C12N 7/00
A61K 39/12

Abstract:

Disclosed are compositions, kits, and methods for enhancing growth in an animal in need thereof. The methods typically comprise administering orally to the animal a composition comprising biodegradable particles, the biodegradable particles comprising a polymer or a co-polymer comprising polymerized lactic acid and having an effective average diameter of 0.5-5 μm. In the methods, the animal is administered a dose of the biodegradable particles that is effective for improving feed conversion rate in the animal in comparison to an animal that is not administered the composition.

US Patent:

20170072051, Mar 16, 2017

Filed:

Oct 24, 2016

Appl. No.:

15/332308

Inventors:

- Auburn AL, US
Ram B. Gupta - Auburn AL, US
Erfan U. Chowdhury - Auburn AL, US
Courtney A. Ober - Carlisle PA, US

Assignee:

Auburn University - Auburn AL

International Classification:

A61K 39/39
C12N 7/00
A61K 9/16
A61K 39/12
A61K 39/118
A61K 31/472

Abstract:

Disclosed are compositions, kits, and methods for inducing an immune response against an infection or a disease. The compositions typically include biodegradable particles having an average effective diameter that such that the biodegradable particles are phagocytosed by antigen presenting cells when the biodegradable particles are administered to a subject in need thereof. Optionally, the compositions include one or more of an adjuvant, an apoptosis inhibitor, and an antigen. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.

US Patent:

20160114303, Apr 28, 2016

Filed:

Oct 23, 2015

Appl. No.:

14/921591

Inventors:

Vijay John - Destrehan LA, US
Gary McPherson - New Orleans LA, US
Ram B. Gupta - Glen Allen VA, US

International Classification:

B01F 17/00
C02F 3/34

Abstract:

The creation of novel halloysite-based compositions is disclosed. In one embodiment, the hollow clay nanotubes of halloysite are loaded with nanoscale zerovalent iron particles. The resulting composition provides an effective manner of remediating chlorinated hydrocarbons. In another embodiment, the hollow clay nanotubes of halloysite are imbibed with dispersants such as DOSS and Tween 80 surfactants. The resulting composition stabilizes oil-in-water emulsions and subsequently releases the surfactants, thereby reducing interfacial tension significantly, which allows much smaller droplets to form and thus provides for more effective oil remediation.

US Patent:

20150297706, Oct 22, 2015

Filed:

Mar 31, 2015

Appl. No.:

14/674711

Inventors:

- Auburn AL, US
Ram B. Gupta - Auburn AL, US
Erfan U. Chowdhury - Auburn AL, US
Courtney A. Ober - Carlisle PA, US

Assignee:

Auburn University - Auburn AL

International Classification:

A61K 39/12
C12N 7/00
A61K 9/16
A61K 31/47
A61K 39/118

Abstract:

Disclosed are compositions, kits, and methods for inducing an immune response against an infection or a disease. The compositions typically include biodegradable particles having an average effective diameter of 0.5-20 μm, and optionally the compositions include one or more of an adjuvant, an apoptosis inhibitor, and an antigen. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.