Ramesh R Patel

US Patent:

6515170, Feb 4, 2003

Filed:

Apr 26, 2001

Appl. No.:

09/843226

Inventors:

Ramesh N. Patel - Bridgewater NJ
Amit Banerjee - St. Louis MO
Venkata B. Nanduri - East Brunswick NJ
Steven L. Goldberg - Basking Ridge NJ
Robert M. Johnston - Whitehouse Station NJ
Thomas P. Tully - Middlesex NJ
Laszlo J. Szarka - East Brunswick NJ
Shankar Swaminathan - North Brunswick NJ
John J. Venit - North Brunswick NJ
Jerome L. Moniot - Chester NJ
William J. Winter - New Brunswick NJ
Neal G. Anderson - Stockton NJ
David A. Lust - Roosevelt NJ
Gerard Crispino - Princeton NJ
Sushil K. Srivastava - Dayton NJ

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

C07C 3200

US Classification:

562432, 562433, 562426, 562485, 562400

Abstract:

The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.

US Patent:

6541242, Apr 1, 2003

Filed:

Nov 16, 1998

Appl. No.:

09/193105

Inventors:

Ramesh N. Patel - Bridgewater NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 740

US Classification:

435280, 435135, 435123

Abstract:

Methods for the enzymatic resolution of mixtures of enantiomers, such as -lactam compounds, which may be employed as intermediates in the preparation of taxanes bearing a C-13 sidechain containing a heterocyclic or cycloalkyl group, the latter useful in the pharmaceutical field.

US Patent:

6649387, Nov 18, 2003

Filed:

Apr 26, 2001

Appl. No.:

09/842987

Inventors:

Ramesh N. Patel - Bridgewater NJ
Amit Banerjee - St. Louis MO
Venkata B. Nanduri - East Brunswick NJ
Steven L. Goldberg - Basking Ridge NJ
Robert M. Johnston - Whitehouse Station NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12N 910

US Classification:

435193, 4352523, 4353201, 435 691, 43525233, 4352541, 536 232

Abstract:

The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.

US Patent:

6800477, Oct 5, 2004

Filed:

Mar 6, 2002

Appl. No.:

10/092263

Inventors:

Ramesh Patel - Bridgewater NJ
Animesh Goswami - Plainsboro NJ
Linda N. Chu - East Brunswick NJ
Venkata B. Nanduri - East Brunswick NJ
Steven L. Goldberg - Basking Ridge NJ
Robert M. Johnston - Whitehouse Station NJ
Mary Jo Donovan - North Brunswick NJ
K. David Mirfakhrae - North Brunswick NJ

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

C12P 4100

US Classification:

435280, 435156, 435911, 435938

Abstract:

The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of -secretase useful in the treatment of Alzheimers disease.

US Patent:

6828119, Dec 7, 2004

Filed:

Dec 14, 2001

Appl. No.:

10/017711

Inventors:

Ramesh Patel - Bridgewater NJ
David Brzozowski - Piscataway NJ
Venkata Nanduri - East Brunswick NJ

Assignee:

Bristol Myers Squibb Company - Princeton NJ

International Classification:

C12P 100

US Classification:

435 41, 435106, 435117

Abstract:

Provided is a method of deprotecting a hydroxide or amine protected with a group of formula where the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.

US Patent:

6929935, Aug 16, 2005

Filed:

Dec 16, 2002

Appl. No.:

10/320104

Inventors:

Venkata B. Nanduri - East Brunswick NJ, US
Robert M. Johnston - Whitehouse Station NJ, US
Steven L. Goldberg - Basking Ridge NJ, US
Paul M. Cino - Bound Brook NJ, US
Ramesh N. Patel - Bridgewater NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12N009/02
C12N015/00
C12N001/20
C07H021/04

US Classification:

435189, 435 4, 435 6, 4352523, 4353201, 435 691, 435 711, 435440, 435325, 4352541, 435410, 536 232, 536 237

Abstract:

This invention relates to an novel 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding 2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated 2-ketoreductase polypeptides, and fragments and variants thereof, and antibodies that specifically bind to 2-ketoreductase polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated 2-ketoreductase nucleic acids, polypeptides, and antibodies, and methods of using 2-ketoreductase in various reactions for industrial or pharmaceutical applications.

US Patent:

6953679, Oct 11, 2005

Filed:

Dec 19, 2001

Appl. No.:

10/024878

Inventors:

Mark E. Salvati - Lawrenceville NJ, US
Toomas Mitt - Plainsboro NJ, US
Ramesh N. Patel - Bridgewater NJ, US
Ronald L. Hanson - Morris Plains NJ, US
David Brzozowski - Piscataway NJ, US
Animesh Goswami - Plainsboro NJ, US
Linda Nga Hoong Chu - East Brunswick NJ, US
Wen-sen Li - Holmdel NJ, US
James H. Simpson - Hillsborough NJ, US
Michael J. Totleben - North Brunswick NJ, US
Weixuan He - Dayton NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P017/10
C12N001/00

US Classification:

435121

Abstract:

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

US Patent:

7063977, Jun 20, 2006

Filed:

Aug 20, 2002

Appl. No.:

10/223800

Inventors:

Ramesh N. Patel - Bridgewater NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 17/02
C12P 17/10

US Classification:

435280, 549510, 549511, 549357, 435123, 435117, 435197

Abstract:

A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formula.