Ramesh I Patel

US Patent:

6348337, Feb 19, 2002

Filed:

Aug 17, 2000

Appl. No.:

09/641176

Inventors:

Ronald L. Hanson - Morris Plains NJ
Ramesh N. Patel - Bridgewater NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 1700

US Classification:

435123, 435117, 435195

Abstract:

A process useful for the preparation of intermediates in synthesis or semi-synthesis of paclitaxel analogs wherein a starting taxane such as 10-deacetylbaccatin III is deacetylated at the C-4 position using a microorganism or an enzyme derived therefrom to provide 4-deacetyltaxanes, such as 4,10-dideacetylbaccatin III.

US Patent:

6433198, Aug 13, 2002

Filed:

Jul 13, 2000

Appl. No.:

09/615436

Inventors:

Ronald L. Hanson - Morris Plains NJ
Ramesh N. Patel - Bridgewater NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D49300

US Classification:

549510, 549511

Abstract:

An enzymatic hydroxylation method for the preparation of compounds useful as intermediates in the preparation of taxanes such as 6--hydroxy-7-deoxypaclitaxel, wherein one or more C-6 hydrogen-bearing taxanes are contacted with an enzyme or microorganism capable of hydroxylating said C-6 carbon to give C-6 hydroxyl-bearing taxane.

US Patent:

6468781, Oct 22, 2002

Filed:

Feb 22, 2000

Appl. No.:

09/510925

Inventors:

Ronald Hanson - Morris Plains NJ
Mary Jo Donovan - North Brunswick NJ
Steven Goldberg - Gillette NJ
Paul A. Jass - Charles City IA
Wen-Sen Li - Holmdel NJ
Ramesh Patel - Bridgewater NJ
Keith Ramig - Orange NJ
Laszlo J. Szarka - East Brunswick NJ
John J. Venit - North Brunswick NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 2106

US Classification:

4352551, 435 692, 435183, 435189, 4352521

Abstract:

Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.

US Patent:

6486331, Nov 26, 2002

Filed:

May 3, 2001

Appl. No.:

09/848464

Inventors:

Ronald L. Hanson - Morris Plains NJ
Paul A. Jass - Charles City IA
Wen-Sen Li - Holmdel NJ
Ramesh Patel - Bridgewater NJ
Keith Ramig - Orange NJ
John J. Venit - North Brunswick NJ

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

C07D31700

US Classification:

549454, 549357, 562579, 560179

Abstract:

Substituted alkylketo compounds of the formula can be converted to the corresponding amino acid by a stereoselective enzymatic process. The resulting amino acid compounds can be employed as starting materials for pharmaceutically active compounds. This invention is directed to the substituted alkylketo compounds and their method of preparation.

US Patent:

59860952, Nov 16, 1999

Filed:

Jan 6, 1992

Appl. No.:

7/817232

Inventors:

Ronald L. Hanson - Morris Plains NJ
Ramesh N. Patel - Bridgewater NJ
Laszlo J. Szarka - East Brunswick NJ

Assignee:

E.R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07D40304

US Classification:

544295

Abstract:

A process is described for preparing a compound of the formula or the S-enantiomer thereof, wherein: R is alkyl, aryl, cycloalkyl, aralkyl, or cycloalkylalkyl, R. sup. 1 is halogen; R. sup. 2 is halogen, alkyl, cycloalkyl, aryl or ##STR1## wherein the process comprises treating the associated racemic alcohol with an acylating agent ##STR2## (wherein L is a leaving group) and an enzyme or microorganism capable of enantioselective acylation. This process may also be used to isolate the unreacted R- or S-alcohol. The acylated product may be enantioselectively hydrolyzed with a lipase or lipase-supplying microorganism to the S- or R-alcohol. Compounds prepared by this invention are useful antipsychotic agents or useful intermediates therefor.

US Patent:

57390169, Apr 14, 1998

Filed:

May 19, 1995

Appl. No.:

8/445120

Inventors:

Ronald L. Hanson - Morris Plains NJ
Ramesh N. Patel - Bridgewater NJ
Laszlo J. Szarka - East Brunswick NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 1702
C12N 914

US Classification:

435117

Abstract:

An enzymatic hydrolysis method for the preparation of compounds useful as intermediates in the preparation of taxanes such as taxol, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups.

US Patent:

55166768, May 14, 1996

Filed:

Jun 15, 1993

Appl. No.:

8/077979

Inventors:

Ronald L. Hanson - Morris Plains NJ
Ramesh N. Patel - Bridgewater NJ
Laszlo J. Szarka - East Brunswick NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 1702
C12N 914
C07D30514

US Classification:

435195

Abstract:

Compounds useful as intermediates in the preparation of taxanes such as taxol are prepared by contacting one or more C-13 acyloxy-bearing taxanes with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. In a preferred embodiment the microorganism is Nocardioides albus ATCC55424, Nocardioides albus ATCC55425 or Nocardioides luteus ATCC55426 or the hydrolase enzyme is isolated from the microorganisms.

US Patent:

61626228, Dec 19, 2000

Filed:

Jan 14, 1999

Appl. No.:

9/231702

Inventors:

Ronald L. Hanson - Morris Plains NJ
Ramesh N. Patel - Bridgewater NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 1702

US Classification:

435123

Abstract:

An enzymatic hydroxylation method for the preparation of compounds useful as intermediates in the preparation of taxanes such as 6-. alpha. -hydroxy-7-deoxypaclitaxel, wherein one or more C-6 hydrogen-bearing taxanes are contacted with an enzyme or microorganism capable of hydroxylating said C-6 carbon to give C-6 hydroxyl-bearing taxane.