Ramesh B Patel

US Patent:

6348337, Feb 19, 2002

Filed:

Aug 17, 2000

Appl. No.:

09/641176

Inventors:

Ronald L. Hanson - Morris Plains NJ
Ramesh N. Patel - Bridgewater NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 1700

US Classification:

435123, 435117, 435195

Abstract:

A process useful for the preparation of intermediates in synthesis or semi-synthesis of paclitaxel analogs wherein a starting taxane such as 10-deacetylbaccatin III is deacetylated at the C-4 position using a microorganism or an enzyme derived therefrom to provide 4-deacetyltaxanes, such as 4,10-dideacetylbaccatin III.

US Patent:

6433198, Aug 13, 2002

Filed:

Jul 13, 2000

Appl. No.:

09/615436

Inventors:

Ronald L. Hanson - Morris Plains NJ
Ramesh N. Patel - Bridgewater NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D49300

US Classification:

549510, 549511

Abstract:

An enzymatic hydroxylation method for the preparation of compounds useful as intermediates in the preparation of taxanes such as 6--hydroxy-7-deoxypaclitaxel, wherein one or more C-6 hydrogen-bearing taxanes are contacted with an enzyme or microorganism capable of hydroxylating said C-6 carbon to give C-6 hydroxyl-bearing taxane.

US Patent:

6468781, Oct 22, 2002

Filed:

Feb 22, 2000

Appl. No.:

09/510925

Inventors:

Ronald Hanson - Morris Plains NJ
Mary Jo Donovan - North Brunswick NJ
Steven Goldberg - Gillette NJ
Paul A. Jass - Charles City IA
Wen-Sen Li - Holmdel NJ
Ramesh Patel - Bridgewater NJ
Keith Ramig - Orange NJ
Laszlo J. Szarka - East Brunswick NJ
John J. Venit - North Brunswick NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 2106

US Classification:

4352551, 435 692, 435183, 435189, 4352521

Abstract:

Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.

US Patent:

6486331, Nov 26, 2002

Filed:

May 3, 2001

Appl. No.:

09/848464

Inventors:

Ronald L. Hanson - Morris Plains NJ
Paul A. Jass - Charles City IA
Wen-Sen Li - Holmdel NJ
Ramesh Patel - Bridgewater NJ
Keith Ramig - Orange NJ
John J. Venit - North Brunswick NJ

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

C07D31700

US Classification:

549454, 549357, 562579, 560179

Abstract:

Substituted alkylketo compounds of the formula can be converted to the corresponding amino acid by a stereoselective enzymatic process. The resulting amino acid compounds can be employed as starting materials for pharmaceutically active compounds. This invention is directed to the substituted alkylketo compounds and their method of preparation.

US Patent:

7420079, Sep 2, 2008

Filed:

Nov 18, 2003

Appl. No.:

10/716012

Inventors:

Truc Chi Vu - Watchung NJ, US
David B. Brzozowski - Island Lake IL, US
Rita Fox - Princeton NJ, US
Ronald L. Hanson - Morris Plains NJ, US
Sergei V. Kolotuchin - Roselle Park NJ, US
John A. Mazzullo - Florence SC, US
Ramesh N. Patel - Bridgewater NJ, US
Jianji Wang - Dayton NJ, US
Kwok Wong - Lawrenceville NJ, US
Jurong Yu - Dayton NJ, US
Jason J. Zhu - East Brunswick NJ, US
David R. Magnin - Hamilton NJ, US
David J. Augeri - Princeton NJ, US
Lawrence G. Hamann - Cherry Hill NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07C 69/52
C07C 229/02

US Classification:

560155, 560174, 560189

Abstract:

Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.

US Patent:

7705033, Apr 27, 2010

Filed:

Jul 28, 2008

Appl. No.:

12/181216

Inventors:

Truc Chi Vu - Watchung NJ, US
David B. Brzozowski - Pattersonville NY, US
Rita Fox - Princeton NJ, US
Ronald L. Hanson - Morris Plains NJ, US
Sergei V. Kolotuchin - Roselle Park NJ, US
John A. Mazzullo - Florence SC, US
Ramesh N. Patel - Bridgewater NJ, US
Jianji Wang - Dayton NJ, US
Kwok Wong - Lawrenceville NJ, US
Jurong Yu - Dayton NJ, US
Jason J. Zhu - East Brunswick NJ, US
David R. Magnin - Sumter SC, US
David J. Augeri - Princeton NJ, US
Lawrence G. Hamann - North Grafton MA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/403
C07D 209/52

US Classification:

514412, 548452

Abstract:

Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.

US Patent:

8278462, Oct 2, 2012

Filed:

Feb 25, 2010

Appl. No.:

12/712958

Inventors:

Truc Chi Vu - Watchung NJ, US
David B. Brzozowski - Pattersonville NY, US
Rita Fox - Princeton NJ, US
Ronald L. Hanson - Morris Plains NJ, US
Sergei V. Kolotuchin - Roselle Park NJ, US
John A. Mazzullo - Florence SC, US
Ramesh N. Patel - Bridgewater NJ, US
Jianji Wang - Dayton NJ, US
Kwok Wong - Lawrenceville NJ, US
Jurong Yu - Dayton NJ, US
Jason J. Zhu - East Brunswick NJ, US
David R. Magnin - Sumter SC, US
David J. Augeri - Princeton NJ, US
Lawrence G. Hamann - North Grafton MA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 209/52

US Classification:

548452

Abstract:

Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.

US Patent:

20130012723, Jan 10, 2013

Filed:

Aug 31, 2012

Appl. No.:

13/601477

Inventors:

Truc Chi Vu - Watchung NJ, US
David B. Brzozowski - Pattersonville NY, US
Rita Fox - Princeton NJ, US
Ronald L. Hanson - Morris Plains NJ, US
Sergei V. Kolotuchin - Roselle Park NJ, US
John A. Mazzullo - Florence SC, US
Ramesh N. Patel - Bridgewater NJ, US
Jianji Wang - Dayton NJ, US
Kwok Wong - Lawrenceville NJ, US
Jurong Yu - Dayton NJ, US
Jason J. Zhu - East Brunswick NJ, US
David R. Magnin - Sumter SC, US
David J. Augeri - Princeton NJ, US
Lawrence G. Hamann - North Grafton MA, US

Assignee:

BRISTOL-MYERS SQUIBB COMPANY - Princeton NJ

International Classification:

C07D 209/52
C12N 1/21
C12N 1/19
C07D 207/22

US Classification:

548452, 548536, 43525233, 43525423

Abstract:

Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.