Ramesh R Patel

US Patent:

6515170, Feb 4, 2003

Filed:

Apr 26, 2001

Appl. No.:

09/843226

Inventors:

Ramesh N. Patel - Bridgewater NJ
Amit Banerjee - St. Louis MO
Venkata B. Nanduri - East Brunswick NJ
Steven L. Goldberg - Basking Ridge NJ
Robert M. Johnston - Whitehouse Station NJ
Thomas P. Tully - Middlesex NJ
Laszlo J. Szarka - East Brunswick NJ
Shankar Swaminathan - North Brunswick NJ
John J. Venit - North Brunswick NJ
Jerome L. Moniot - Chester NJ
William J. Winter - New Brunswick NJ
Neal G. Anderson - Stockton NJ
David A. Lust - Roosevelt NJ
Gerard Crispino - Princeton NJ
Sushil K. Srivastava - Dayton NJ

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

C07C 3200

US Classification:

562432, 562433, 562426, 562485, 562400

Abstract:

The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.

US Patent:

6541242, Apr 1, 2003

Filed:

Nov 16, 1998

Appl. No.:

09/193105

Inventors:

Ramesh N. Patel - Bridgewater NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 740

US Classification:

435280, 435135, 435123

Abstract:

Methods for the enzymatic resolution of mixtures of enantiomers, such as -lactam compounds, which may be employed as intermediates in the preparation of taxanes bearing a C-13 sidechain containing a heterocyclic or cycloalkyl group, the latter useful in the pharmaceutical field.

US Patent:

6649387, Nov 18, 2003

Filed:

Apr 26, 2001

Appl. No.:

09/842987

Inventors:

Ramesh N. Patel - Bridgewater NJ
Amit Banerjee - St. Louis MO
Venkata B. Nanduri - East Brunswick NJ
Steven L. Goldberg - Basking Ridge NJ
Robert M. Johnston - Whitehouse Station NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12N 910

US Classification:

435193, 4352523, 4353201, 435 691, 43525233, 4352541, 536 232

Abstract:

The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.

US Patent:

6800477, Oct 5, 2004

Filed:

Mar 6, 2002

Appl. No.:

10/092263

Inventors:

Ramesh Patel - Bridgewater NJ
Animesh Goswami - Plainsboro NJ
Linda N. Chu - East Brunswick NJ
Venkata B. Nanduri - East Brunswick NJ
Steven L. Goldberg - Basking Ridge NJ
Robert M. Johnston - Whitehouse Station NJ
Mary Jo Donovan - North Brunswick NJ
K. David Mirfakhrae - North Brunswick NJ

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

C12P 4100

US Classification:

435280, 435156, 435911, 435938

Abstract:

The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of -secretase useful in the treatment of Alzheimers disease.

US Patent:

6828119, Dec 7, 2004

Filed:

Dec 14, 2001

Appl. No.:

10/017711

Inventors:

Ramesh Patel - Bridgewater NJ
David Brzozowski - Piscataway NJ
Venkata Nanduri - East Brunswick NJ

Assignee:

Bristol Myers Squibb Company - Princeton NJ

International Classification:

C12P 100

US Classification:

435 41, 435106, 435117

Abstract:

Provided is a method of deprotecting a hydroxide or amine protected with a group of formula where the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.

US Patent:

6929935, Aug 16, 2005

Filed:

Dec 16, 2002

Appl. No.:

10/320104

Inventors:

Venkata B. Nanduri - East Brunswick NJ, US
Robert M. Johnston - Whitehouse Station NJ, US
Steven L. Goldberg - Basking Ridge NJ, US
Paul M. Cino - Bound Brook NJ, US
Ramesh N. Patel - Bridgewater NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12N009/02
C12N015/00
C12N001/20
C07H021/04

US Classification:

435189, 435 4, 435 6, 4352523, 4353201, 435 691, 435 711, 435440, 435325, 4352541, 435410, 536 232, 536 237

Abstract:

This invention relates to an novel 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding 2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated 2-ketoreductase polypeptides, and fragments and variants thereof, and antibodies that specifically bind to 2-ketoreductase polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated 2-ketoreductase nucleic acids, polypeptides, and antibodies, and methods of using 2-ketoreductase in various reactions for industrial or pharmaceutical applications.

US Patent:

7063977, Jun 20, 2006

Filed:

Aug 20, 2002

Appl. No.:

10/223800

Inventors:

Ramesh N. Patel - Bridgewater NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 17/02
C12P 17/10

US Classification:

435280, 549510, 549511, 549357, 435123, 435117, 435197

Abstract:

A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formula.

US Patent:

7083973, Aug 1, 2006

Filed:

Sep 12, 2003

Appl. No.:

10/661893

Inventors:

Ramesh N. Patel - Bridgewater NJ, US
Linda Chu - East Brunswick NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12S 13/00
C12P 7/04
C12P 7/22

US Classification:

435280, 435157, 435156, 4352521

Abstract:

The present invention relates to a process for the stereoselective enzymatic reduction of 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes utilizing certain species of and. The product 1-halo-2-hydroxy-3-(protected)amino-4-substituted-butanes, which are useful as intermediates in the synthesis of compounds that are inhibitors of ACE, renin and HIV proteases, are obtained in high yield and, particularly, in very high diastereomeric purity. The process is advantageously highly selective for the (3S,2R) enantiomer of the product.