Ran C Zeimer

US Patent:

6440950, Aug 27, 2002

Filed:

Sep 29, 2000

Appl. No.:

09/676832

Inventors:

Ran Zeimer - Reisterstown MD

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 31695

US Classification:

514 63, 514 78, 514 79, 424450

Abstract:

Disclosed are methods and materials for visualizing or treating vasculature. The methods and materials in this invention relate to selective and non-invasive visualization, or treatment such as chemical occlusion, of vasculature in the mammalian eye. The methods utilize fluorescent dyes and tissue-reactive substances encapsulated within heat-sensitive liposomes which are subsequently heated to release the contents thereof at a pre-determined anatomical locus. The methods of this invention further utilize tissue-reactive agents which, when activated, are effective to cause localized tissue damage and occlusion of blood vessels and/or blood sinuses. The materials of this invention relate to diagnostic reagents and kits for visualizing or treating a mammalian blood vessel or sinus.

US Patent:

62674773, Jul 31, 2001

Filed:

Aug 21, 1998

Appl. No.:

9/125585

Inventors:

Avner Karpol - Nes Ziona, IL
Ran Zeimer - Baltimore MD

Assignee:

Talia Technology Ltd. - Mevasseret Zion

International Classification:

A61B 310

US Classification:

351221

Abstract:

Disclosed is a three dimensional imaging scanning apparatus for retinal thickness and structure non-invasive analysis. The apparatus includes an optical path having a light source, common focusing optic and beam deflector for both incident and reflected beams going to and returning from the retina of an eye, and an imaging device. The apparatus further includes separate optical paths for imaging the fundus and iris of the eye. The speckles caused by retina non-uniformity can be removed by vibrating the common beam deflector during the image acquisition time. An eye model is obtained by spatially integrating images of the retina, the fundus and the iris.

US Patent:

55469418, Aug 20, 1996

Filed:

Oct 28, 1994

Appl. No.:

8/330981

Inventors:

Ran C. Zeimer - Reisterstown MD
George J. Jost - Lake In The Hills IL
Robert C. Bainbridge - Sandwich IL
Richard Schwarzbach - Naperville IL
Charles Ware - Warrenville IL
Kathleen D. Zebrowski - Hinsdale IL

Assignee:

CDS Technologies, L.L.C. - West Chicago IL

International Classification:

A61B 316

US Classification:

128652

Abstract:

An improved tenometer provides for a bellows and a stepper motor to pressurize the interior of a probe in the barrel into which the probe is fitted for moving the probe outward towards a patient's eye. The device also includes a laser for improved centering of the patient's eye over the eye piece, and a safety detection device for terminating operation of the tenometer if the probe fails to move along the barrel after a given amount of pressure is applied to the interior of the barrel and the probe. A rotatable occluder near the head rest for blocking the eye not being tested and a computer in the instrument records the eye being tested and the test results.

US Patent:

62487272, Jun 19, 2001

Filed:

Jun 21, 1999

Appl. No.:

9/336895

Inventors:

Ran Zeimer - Reisterstown MD

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 31695
A61K 3166
A61K 9127

US Classification:

514 63

Abstract:

Disclosed are methods and materials for visualizing or treating vasculature. The methods and materials in this invention relate to selective and non-invasive visualization, or treatment such as chemical occlusion, of vasculature in the mammalian eye. The methods utilize fluorescent dyes and tissue-reactive substances encapsulated within heat-sensitive liposomes which are subsequently heated to release the contents thereof at a pre-determined anatomical locus. The methods of this invention further utilize tissue-reactive agents which, when activated, are effective to cause localized tissue damage and occlusion of blood vessels and/or blood sinuses. The materials of this invention relate to diagnostic reagents and kits for visualizing or treating a mammalian blood vessel or sinus.

US Patent:

48830615, Nov 28, 1989

Filed:

Feb 29, 1988

Appl. No.:

7/162011

Inventors:

Ran C. Zeimer - Chicago IL

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

A61B 510
A61B 600

US Classification:

128665

Abstract:

A method and apparatus for measuring the retinal or nerve fiber layer thickness. A beam of light is focused on the retina. Reflected beams from the anterior and posterior surfaces of the retina are detected and analyzed to quantitavely determine the retinal thickness.

US Patent:

59431164, Aug 24, 1999

Filed:

Mar 31, 1998

Appl. No.:

9/052117

Inventors:

Ran Zeimer - Reisterstown MD

Assignee:

Johns Hopkins University - Baltimore MD

International Classification:

A61B 300

US Classification:

351221

Abstract:

A system for obtaining images of the fundus of an eye includes an illumination device which directs a light beam onto a portion of the fundus of the eye, and a video camera which records the portion of the light reflected from the fundus of the eye. The pupil of the eye is automatically centered and brought into focus, and the fundus of the eye is then automatically brought into focus. A plurality of target images are presented at different locations in space so that the eye will move when focusing on these different locations. As the eye moves, different areas of the fundus are illuminated, and images of these different areas of the fundus are recorded by the video camera. The plurality of images from the different areas of the fundus are then automatically arranged by a computer in a mosaic image representative of a section of the fundus including the plurality of areas. Data representative of the mosaic image is transmitted to a remote site for analysis. Additionally, the system can perform visual acuity and perimetry testing on the eye whose fundus is being imaged.

US Patent:

48910430, Jan 2, 1990

Filed:

May 28, 1987

Appl. No.:

7/055047

Inventors:

Ran C. Zeimer - Chicago IL
Bahram Khoobehi - River Forest IL
Gholam A. Peyman - Chicago IL

Assignee:

Board of Trustees of the University of Illinois - Chicago IL

International Classification:

A61M 130

US Classification:

604 20

Abstract:

A system for selectively releasing materials, such as drugs or dyes, at a specific site in the body of an animal. The system uses laser radiation to rupture laser light-absorbing and heat-sensitive lipid vesicles containing the drugs or dyes, thereby releasing these materials at the specific site irradiated by the laser. By using this system, the location and concentration of the materials are controlled as well as the duration of the materials' release and the release can be triggered repetitively. The laser beam used is visible or its location can be made visible to the naked eye so that the location and size of the beam's contact with the irradiated tissue can be observed and adjusted.

US Patent:

61403148, Oct 31, 2000

Filed:

Jun 21, 1999

Appl. No.:

9/336896

Inventors:

Ran Zeimer - Reisterstown MD

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 31695
A61K 31685

US Classification:

514 63

Abstract:

Disclosed are methods and materials for visualizing or treating vasculature. The methods and materials in this invention relate to selective and non-invasive visualization, or treatment such as chemical occlusion, of vasculature in the mammalian eye. The methods utilize fluorescent dyes and tissue-reactive substances encapsulated within heat-sensitive liposomes which are subsequently heated to release the contents thereof at a pre-determined anatomical locus. The methods of this invention further utilize tissue-reactive agents which, when activated, are effective to cause localized tissue damage and occlusion of blood vessels and/or blood sinuses. The materials of this invention relate to diagnostic reagents and kits for visualizing or treating a mammalian blood vessel or sinus.