Randal D Goff

US Patent:

8552176, Oct 8, 2013

Filed:

Oct 17, 2011

Appl. No.:

13/274814

Inventors:

Jon S. Thorson - Lexington KY, US
Randal D. Goff - Madison WI, US

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

C07H 5/04
C40B 40/12

US Classification:

536 291, 506 19, 514 42

Abstract:

A library of glycosylated chlorambucil analogs which are useful as anti-tumor and/or anti-metastatic agents is disclosed. The glycosylated chlorambucil analogs have the general formula.

US Patent:

20100190705, Jul 29, 2010

Filed:

Oct 26, 2009

Appl. No.:

12/589638

Inventors:

Albee Messing - Madison WI, US
Woosung Cho - Plano TX, US
Jon Scott Thorson - Middleton WI, US
Randal D. Goff - Madison WI, US

International Classification:

A61K 38/17
A61K 31/715
A61K 31/675
A61K 31/66
A61K 31/593
A61K 31/19
A61K 31/565
A61K 31/396
A61K 31/55
A61K 31/5415
A61K 31/495
A61K 31/519
A61K 31/445
A61K 31/4535
A61K 31/44
A61K 31/40
A61K 31/382
A61K 31/352
A61K 31/165
A61K 31/135
A61K 31/122
A61P 25/00
A61K 31/566

US Classification:

514 12, 514 61, 514 80, 514118, 514167, 514169, 514182, 514183, 514217, 5142255, 5142258, 514256, 5142592, 514317, 514324, 514356, 514422, 514437, 514456, 514568, 514628, 514646, 514648, 514653, 514678, 514680, 514180

Abstract:

Provided herein are methods of decreasing glial fibrillary acidic protein (GFAP) levels in a cell. Such methods include administering an effective amount of a GFAP lowering compound to the cell. Also provided are compounds useful for the treatment of Alexander disease in subjects at risk of or diagnosed with Alexander disease and methods for the identification of such compounds.

US Patent:

20120108530, May 3, 2012

Filed:

Jan 7, 2010

Appl. No.:

13/143639

Inventors:

Randal D. Goff - Madison WI, US
Jon Scott Thorson - Middleton WI, US

International Classification:

A61K 31/704
A61P 31/18
A61P 35/00
C07H 5/06
C40B 40/12

US Classification:

514 42, 536 291, 506 19

Abstract:

Using neoglycosylation, the impact of differential glycosylation upon the divergent anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA) was examined. Each member from a library of 37 differentially glycosylated BA variants was tested for anticancer and anti-HIV activities. Enhanced analogs for both desired activities were discovered with the corresponding antitumor or antiviral enhancements diverging, based upon the appended sugar, into two distinct compound subsets.

US Patent:

20130225540, Aug 29, 2013

Filed:

Feb 4, 2013

Appl. No.:

13/758796

Inventors:

Albee Messing - Madison WI, US
Woosung Cho - Plano TX, US
Jon Scott Thorson - Lexington KY, US
Randal D. Goff - Pace FL, US

International Classification:

A61K 31/56
A61K 31/352
A61K 31/135
A61K 31/55

US Classification:

514169, 435375, 514217, 514456, 514649

Abstract:

Provided herein are methods of decreasing glial fibrillary acidic protein (GFAP) levels in a cell. Such methods include administering an effective amount of a GFAP lowering compound to the cell. Also provided are compounds useful for the treatment of Alexander disease in subjects at risk of or diagnosed with Alexander disease and methods for the identification of such compounds.