Randall Lynn Halcomb

US Patent:

7968544, Jun 28, 2011

Filed:

Jun 26, 2008

Appl. No.:

12/215598

Inventors:

Michael Graupe - Pacifica CA, US
Randall L. Halcomb - Foster City CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07D 473/18
A61K 31/522
A61P 31/20
A61K 31/14

US Classification:

5142342, 51425216, 5142632, 51426322, 51426337, 514218, 51421706, 544118, 544276, 540575, 540600

Abstract:

The present application includes a compound of Formula I or II:.

US Patent:

8088368, Jan 3, 2012

Filed:

May 12, 2010

Appl. No.:

12/779023

Inventors:

Hongyan Guo - Foster City CA, US
Darryl Kato - Foster City CA, US
Thorsten A. Kirschberg - Foster City CA, US
Hongtao Liu - Foster City CA, US
John O. Link - Foster City CA, US
Michael L. Mitchell - Foster City CA, US
Jay P. Parrish - Foster City CA, US
Jianyu Sun - Foster City CA, US
James Taylor - Foster City CA, US
Elizabeth M. Bacon - Foster City CA, US
Eda Canales - Foster City CA, US
Aesop Cho - Foster City CA, US
Choung U. Kim - Foster City CA, US
Jeromy J. Cottell - Foster City CA, US
Manoj C. Desai - Foster City CA, US
Randall L. Halcomb - Foster City CA, US
Scott E. Lazerwith - Foster City CA, US
Richard L. Mackman - Foster City CA, US
Hyung-Jung Pyun - Foster City CA, US
Joseph H. Saugier - Foster City CA, US
James D. Trenkle - Foster City CA, US
Winston C. Tse - Foster City CA, US
William J. Watkins - Foster City CA, US
Lianhong Xu - Foster City CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

A61K 31/4178
A61K 31/435
A61K 31/55
A61K 31/438
A61K 31/496
A61K 31/5415
A61K 31/708
A61K 31/7052
A61K 38/21
C07D 403/14
C07D 401/14
C07D 417/14
A61P 31/14

US Classification:

424 854, 424 857, 514217, 5142258, 51425405, 514278, 514299, 514397, 514 43, 544370, 544 35, 546112, 546 16, 5483131, 540587

Abstract:

The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

US Patent:

8273341, Sep 25, 2012

Filed:

Nov 8, 2011

Appl. No.:

13/291977

Inventors:

Hongyan Guo - Foster City CA, US
Darryl Kato - Foster City CA, US
Thorsten A. Kirschberg - Foster City CA, US
Hongtao Liu - Foster City CA, US
John O. Link - Foster City CA, US
Michael L. Mitchell - Foster City CA, US
Jay P. Parrish - Foster City CA, US
Michael Graupe - Foster City CA, US
Jianyu Sun - Foster City CA, US
James Taylor - Foster City CA, US
Elizabeth M. Bacon - Foster City CA, US
Eda Canales - Foster City CA, US
Aesop Cho - Foster City CA, US
Choung U. Kim - Foster City CA, US
Jeromy J. Cottell - Foster City CA, US
Manoj C. Desai - Foster City CA, US
Randall L. Halcomb - Foster City CA, US
Evan S. Krygowski - Foster City CA, US
Scott E. Lazerwith - Foster City CA, US
Qi Liu - Foster City CA, US
Richard Mackman - Foster City CA, US
Hyung-Jun Pyun - Foster Cit CA, US
Joseph H. Saugier - Foster City CA, US
James D. Trenkle - Foster City CA, US
Winston C. Tse - Foster City CA, US
Randall W. Vivian - Foster City CA, US
Scott D. Schroeder - Foster City CA, US
William J. Watkins - Foster City CA, US
Lianhong Xu - Foster City CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

A61K 31/4178
A61K 31/435
A61K 31/55
A61K 31/438
A61K 31/496
A61K 31/5415
A61K 31/708
A61K 31/7052
A61K 38/21
C07D 403/14
C07D 401/14
C07D 417/14
A61P 31/14

US Classification:

424 854, 424 857, 514217, 5142258, 51425405, 514278, 514299, 514397, 514 43, 544370, 544 35, 546112, 546 16, 5483131, 540587

Abstract:

The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

US Patent:

8338593, Dec 25, 2012

Filed:

Jul 6, 2007

Appl. No.:

12/303214

Inventors:

Lee S. Chong - Newark CA, US
Manoj C. Desai - Pleasant Hill CA, US
Brian Gallagher - Goleta CA, US
Michael Graupe - Pacifica CA, US
Randall L. Halcomb - Foster City CA, US
Hong Yang - Fremont CA, US
Jennifer R. Zhang - Foster City CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07F 9/6561
C07D 473/16
A61K 31/675
A61P 31/20
C07D 473/40

US Classification:

544157, 544244, 544277, 544276

Abstract:

The present application provides for a compound of Formula (I) or (II): or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional active agent.

US Patent:

8367670, Feb 5, 2013

Filed:

Dec 7, 2009

Appl. No.:

12/632194

Inventors:

Manoj C. Desai - Pleasant Hill CA, US
Randall L. Halcomb - Foster City CA, US
Paul Hrvatin - South San Francisco CA, US
Hon Chung Hui - San Mateo CA, US
Ryan McFadden - Foster City CA, US
Paul A. Roethle - San Francisco CA, US
Hong Yang - Fremont CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07D 475/06
C07D 475/08
C07D 475/12
C07D 487/04
A61K 31/519
A61P 31/12
A61P 35/00

US Classification:

514249, 544258, 544259

Abstract:

Provided are modulators of TLRs of Formula II:.

US Patent:

8476270, Jul 2, 2013

Filed:

Sep 10, 2010

Appl. No.:

12/879697

Inventors:

Randall L. Halcomb - Foster City CA, US
Paul A. Roethle - San Francisco CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

A61K 31/495

US Classification:

514249, 544350, 548518

Abstract:

The present invention relates to novel dihydropyrido[4,3 -b]pyrazin-3(4H)-ones of the general formula:.

US Patent:

8507507, Aug 13, 2013

Filed:

Oct 15, 2010

Appl. No.:

12/905268

Inventors:

Randall L. Halcomb - Foster City CA, US
Paul A. Roethle - San Francisco CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

A61K 31/522
C07D 473/00

US Classification:

51426337, 544276

Abstract:

The present application includes novel modulators of TLRs, compositions containing such compounds, therapeutic methods that include the administration of such compounds.

US Patent:

8575118, Nov 5, 2013

Filed:

Jul 19, 2012

Appl. No.:

13/553517

Inventors:

Hongyan Guo - San Mateo CA, US
Darryl Kato - San Francisco CA, US
Thorsten A. Kirschberg - Redwood City CA, US
Hongtao Liu - Foster City CA, US
John O. Link - San Francisco CA, US
Michael L. Mitchell - Hayward CA, US
Jay P. Parrish - Redwood City CA, US
Jianyu Sun - Surrey, CA
James Taylor - San Mateo CA, US
Elizabeth M. Bacon - Burlingame CA, US
Eda Canales - San Mateo CA, US
Aesop Cho - Mountain View CA, US
Choung U. Kim - San Carlos CA, US
Jeromy J. Cottell - Redwood City CA, US
Manoj C. Desai - Pleasant Hill CA, US
Randall L. Halcomb - Foster City CA, US
Michael Graupe - Pacifica CA, US
Evan S. Krygowski - Belmont CA, US
Scott E. Lazerwith - San Francisco CA, US
Qi Liu - Union City CA, US
Richard Mackman - Millbrae CA, US
Hyung-Jung Pyun - Fremont CA, US
Joseph H. Saugier - Livermore CA, US
James Trenkle - Oakland CA, US
Winston C. Tse - Redwood City CA, US
Randall W. Vivian - San Mateo CA, US
Scott D. Schroeder - Foster City CA, US
William J. Watkins - Saratoga CA, US
Lianhong Xu - Palo Alto CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07D 401/14
C07D 403/04
C07D 403/14
C07D 409/14
C07D 417/04
C07D 417/14
C07D 495/04
A61K 31/4184
A61K 31/501
A61K 31/439
A61K 31/7056
A61K 31/7068
A61K 31/496
A61P 31/14

US Classification:

514 43, 51425206, 51425406, 514299, 514394, 514 49

Abstract:

The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.