Randall T Lee

US Patent:

7252819, Aug 7, 2007

Filed:

Nov 7, 2002

Appl. No.:

10/291202

Inventors:

Randall J. Lee - San Francisco CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A01K 48/00

US Classification:

424 9321, 435 691, 4353201, 435325

Abstract:

The invention provides methods for establishing electrical coupling between cardiomyocytes and recombinant cells which have been genetically engineered to express a connexin protein such as connexin 43 (Cx43) protein. The invention is based on the discovery that genetic modification of skeletal muscle cells to express a recombinant connexin, enables the genetically modified cells to establish electrocommunication with cardiac cells via gap junctions. The recombinant connexin-expressing cells can be used for repair of cardiac tissue and for treatment of cardiac disease by transplantation into cardiac tissue.

US Patent:

7494644, Feb 24, 2009

Filed:

Dec 5, 2006

Appl. No.:

11/635810

Inventors:

Randall J. Lee - San Francisco CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A01K 48/00

US Classification:

424 9321, 435 691, 4353201, 435325

Abstract:

The invention provides methods for establishing electrical coupling between cardiomyocytes and recombinant cells which have been genetically engineered to express a connexin protein such as connexin 43 (Cx43) protein. The invention is based on the discovery that genetic modification of skeletal muscle cells to express a recombinant connexin, enables the genetically modified cells to establish electrocommunication with cardiac cells via gap junctions. The recombinant connexin-expressing cells can be used for repair of cardiac tissue and for treatment of cardiac disease by transplantation into cardiac tissue.

US Patent:

8323293, Dec 4, 2012

Filed:

Dec 29, 2008

Appl. No.:

12/810986

Inventors:

Mickey Morgan - Frisco TX, US
John Peloza - Dallas TX, US
Randall Lee - Arlington TX, US
Michael Keane - Downingtown PA, US
William Miller - Downingtown PA, US
James Talbot - Lititz PA, US
Daniel Vennard - Clayton DE, US
Josef Gabelberger - West Chester PA, US

Assignee:

Synthes GmbH - Oberdorf

International Classification:

A61B 17/56

US Classification:

606 99, 606104, 606279, 606329, 227119, 227137

Abstract:

The present invention relates to a surgical method or procedure for securing a prosthesis to bone. More particularly, the present invention relates to (i) a surgical method or procedure for securing a low load bearing prosthesis such as, for example, an adhesion barrier, to a patient's bone, (ii) a tack or drive screw for securing the low load bearing prosthesis and (iii) associated instrumentation for driving the tack or drive screw into the patient's bone.

US Patent:

8500749, Aug 6, 2013

Filed:

Apr 19, 2011

Appl. No.:

13/089517

Inventors:

Randall F. Lee - Arlington TX, US
Jack E. Zigler - Plano TX, US
Richard D. Guyer - Plano TX, US
Michael J. Mojica - Arlington TX, US

Assignee:

Prescient Surgical Designs, LLC - Grand Prairie TX

International Classification:

A61B 17/70

US Classification:

606 99, 606 86 A

Abstract:

An instrument for inserting an implant between vertebrae includes an upper and a lower ramp each having a respective proximal and a distal end. A bracket assembly is coupled to the upper and lower ramps at the proximal ends. The bracket assembly biases the upper and lower ramps closed at the distal end. A drive member has a longitudinal axis and a screw thread thereon. The drive member is disposed between the upper and lower ramps and extends through a passage in the bracket assembly. An adjustable spreader is operably coupled to the drive member and movable between the upper and lower ramps along the longitudinal axis by rotation of the drive member. The adjustable spreader separates the upper ramp from the lower ramp during forwardly movement along the longitudinal axis. An implant holder is coupled to the adjustable spreader.

US Patent:

8540721, Sep 24, 2013

Filed:

Apr 4, 2011

Appl. No.:

13/079142

Inventors:

Randall F. Lee - Arlington TX, US
Michael J. Mojica - Arlington TX, US

Assignee:

Amicus Design Group, LLC - Arlington TX

International Classification:

A61B 17/70
A61B 17/88

US Classification:

606 86A, 606279

Abstract:

Methods and apparatus for inserting an implant into an intervertebral cavity between adjacent vertebral bodies provide for: adjust an initial height between inner surfaces of respective first and second ramps of an inserter; simultaneously sliding first and second ramps of the inserter, and the implant, proximally, toward distal ends of the first and second ramps, such that the vertebral contact surfaces of the respective first and second ramps separate and distract the vertebral bodies and receive the implant into the intervertebral space with no compressive loading, while holding an initial angle between the ramps substantially constant; reversing the sliding of the first and second ramps to permit the vertebral bodies to compressively load the implant, again while holding the initial angle therebetween substantially constant; and withdrawing the distal ends of the first and second ramps from the intervertebral space.

US Patent:

8043377, Oct 25, 2011

Filed:

Sep 2, 2006

Appl. No.:

11/469851

Inventors:

Richard D. Guyer - Dallas TX, US
Jack E. Zigler - Dallas TX, US
Randall F. Lee - Arlington TX, US
Cameron Clokie - Toronto, CA

Assignee:

Osprey Biomedical, Inc. - Wilmington DE

International Classification:

A61F 2/44

US Classification:

623 1711

Abstract:

The present invention relates to an implantable intervertebral fusion device for use when surgical fusion of vertebral bodies is indicated. The implant is comprised of bone conforming in size and shape with the end plates of the adjacent vertebrae and has a wedge-shaped profile with a plurality of footings and grooves located on the top and bottom surfaces.

US Patent:

20060002898, Jan 5, 2006

Filed:

May 7, 2003

Appl. No.:

10/519128

Inventors:

Randall Lee - San Francisco CA, US
Mark Maciejewski - Eden Prairie MN, US

International Classification:

A61K 38/17
C12N 5/08

US Classification:

424093700, 435366000, 514002000

Abstract:

The invention provides methods for establishing electrical coupling between cardionyocytes and recombinant cells which have been genetically engineered to express a gap junction protein, eg., Connexin protein such as Connexin 43 (CX43) protein, n invention is based on the discovery that genetic modification of skeletal muscle cells to express a recombinant connexin, enables the genetically modified cells to establish electrocommunication with cardiac cells via gap junctions. The recombinant connexin-expressing cells can be used for repair of cardiac issue and for treatment of cardiac disease by transplantation into cardiac tissue.

US Patent:

20100317958, Dec 16, 2010

Filed:

May 23, 2008

Appl. No.:

12/601373

Inventors:

James Beck - Berkeley CA, US
Venkateswara R. Sattiraju - Union City CA, US
Ali M. Niknejad - Berkelay CA, US
Louis C. Yun - Los Altos CA, US
Randall Lee - Hillsborough CA, US
Surendar Magar - Dublin CA, US
Lois M. Fisher - San Francisco CA, US

International Classification:

A61B 5/0408
A61B 5/04

US Classification:

600391, 600393

Abstract:

A sensor system in accordance with the present invention comprises a plane member, a plurality of electrodes within the plane member, adapted to contact a human body to detect and monitor human generated voltages. The sensor can be applied to monitor a variety of applications relating to health, disease progression, fitness and wellness. Some of the specific applications include the monitoring of ECG, EEG, EMG, glucose, electrolytes, body hydration, dehydration, tissue state and wounds. Various aspects of the invention are shown by illustrating certain embodiments. Many other embodiments can be used to implement the invented schemes.