Randall J Lee

US Patent:

7576186, Aug 18, 2009

Filed:

Apr 23, 2003

Appl. No.:

10/553853

Inventors:

Lawrence G. Lum - Coventry RI, US
Randall J. Lee - Hillsborough CA, US

Assignee:

Roger Williams Hospital - Providence RI
TransTarget, Inc. - Burlingame CA

International Classification:

C07K 16/00

US Classification:

5303873

Abstract:

This invention provides compositions of matter, articles of manufacture and methods for delivering and/or affixing a stem cell to a target tissue. This invention also provides related nucleic acids, vectors, cell, methods of production, and kits.

US Patent:

20060034767, Feb 16, 2006

Filed:

Jul 3, 2003

Appl. No.:

10/520431

Inventors:

Lawrence Lum - Coventry RI, US
Randall Lee - Hillsborough CA, US
Nicola Kouttab - Jamestown RI, US

International Classification:

A61K 49/00
A61K 39/395

US Classification:

424009600, 424133100

Abstract:

The present invention provides a method for tracking and targeting cells in viva. In particular, cells are isolated purified and armed with bispecific antibodies which are directly labeled with a detectable marker, or a second antibody specific for a region of the bispecific antibody is labeled with a detectable marker. The bispecific antibody is specific for a surface antigen of the cell and the second specificity of the specific antigen is for an antigen expressed on cells of tissues, organs or tumors. The armed and labeled cells can be tracked starting from the point of introduction into the animal until the cell reaches the target of interest by phenotyping cells from patient samples, obtained at different time intervals and locations, post-infusion. The isolated and purified cells are useful in any functional assay.

US Patent:

20100055115, Mar 4, 2010

Filed:

Jul 1, 2009

Appl. No.:

12/496591

Inventors:

Lawrence G. Lum - Coventry RI, US
Randall J. Lee - Hillsborough CA, US

International Classification:

A61K 39/395
C07K 14/54
C07K 14/435
C07K 16/00

US Classification:

4241781, 530351, 530350, 5303873

Abstract:

This invention provides compositions of matter, articles of manufacture and methods for delivering and/or affixing a stem cell to a target tissue. This invention also provides related nucleic acids, vectors, cell, methods of production, and kits.

US Patent:

20120121599, May 17, 2012

Filed:

Jan 20, 2012

Appl. No.:

13/355258

Inventors:

Lawrence G. Lum - Coventry RI, US
Randall J. Lee - Hillsborough CA, US

International Classification:

A61K 47/42
C07K 16/46

US Classification:

4241361, 5303873

Abstract:

This invention provides compositions of matter, articles of manufacture and methods for delivering and/or affixing a stem cell to a target tissue. This invention also provides related nucleic acids, vectors, cells, methods of production, and kits.