Randall B Murphy

US Patent:

6399785, Jun 4, 2002

Filed:

Oct 30, 2000

Appl. No.:

09/702143

Inventors:

Randall B. Murphy - Irvington NY
Stephen R. Wilson - Chatham NJ
Quing Lu - Livingston NJ

Assignee:

C-Sixty, Inc. - Toronto

International Classification:

C07D40304

US Classification:

548417, 548460, 549416, 549432, 549439, 556482, 558388, 560 8, 560124, 568303, 568308, 568579, 568630, 568632, 568808

Abstract:

The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the C fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.

US Patent:

6448412, Sep 10, 2002

Filed:

Oct 30, 2000

Appl. No.:

09/702144

Inventors:

Randall B. Murphy - Irvington NY
Stephen R. Wilson - Chatham NJ
Quing Lu - Livingston NJ

Assignee:

Sphere Biosystems, Inc. - Chatham NJ

International Classification:

C07D48700

US Classification:

548417, 548460, 549416, 549432, 549439, 556482, 560 8, 560124, 562303, 562308, 562579, 562630, 568632, 568808, 558388

Abstract:

The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the C fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.

US Patent:

6458547, Oct 1, 2002

Filed:

Dec 12, 1997

Appl. No.:

08/990103

Inventors:

Bruce J. Bryan - Beverly Hills CA
Stephen Gaalema - Colorado Springs CO
Randall B. Murphy - Irvington NY

Assignee:

Prolume, Ltd. - Beverly Hills CA

International Classification:

G01N 3353

US Classification:

435 71, 435 6, 4352887, 435808, 435973, 435975, 436172, 436527, 436805, 422 57, 422 58, 422 8205, 422 8208, 356215, 356222, 356317

Abstract:

Solid phase methods for the identification of an analyte in a biological medium, such as a body fluid, using bioluminescence are provided. A chip designed for performing the method and detecting the bioluminescence is also provided. Methods employing biomineralization for depositing silicon on a matrix support are also provided. A synthetic synapse is also provided.

US Patent:

6649356, Nov 18, 2003

Filed:

Apr 19, 2002

Appl. No.:

10/126139

Inventors:

Bruce J. Bryan - Beverly Hills CA
Stephen Gaalema - Colorado Springs CO
Randall B. Murphy - Irvington NY

Assignee:

Prolume, Ltd. - Beverly Hills CA

International Classification:

G01N 2100

US Classification:

435 71, 435 6, 435 79, 4352887, 435808, 435973, 435975, 436164, 436122, 436518, 436524, 436527, 436532, 436805, 422 57, 422 58, 422 681, 422 8205, 422 8208, 356215, 356222, 356317

Abstract:

Solid phase methods for the identification of an analyte in a biological medium, such as a body fluid, using bioluminescence are provided. A chip designed for performing the method and detecting the bioluminescence is also provided. Methods employing biomineralization for depositing silicon on a matrix support are also provided. A synthetic synapse is also provided.

US Patent:

6649357, Nov 18, 2003

Filed:

Apr 19, 2002

Appl. No.:

10/126798

Inventors:

Bruce J. Bryan - Beverly Hills CA
Stephen Gaalema - Colorado Springs CO
Randall B. Murphy - Irvington NY

Assignee:

Prolume, Ltd. - Beverly Hills CA

International Classification:

G01N 2100

US Classification:

435 71, 435 6, 435 79, 4352887, 435808, 435973, 435975, 436164, 436172, 436518, 436524, 436527, 436532, 436805, 422 57, 422 58, 422 681, 422 8205, 422 8208, 356215, 356222, 356317

Abstract:

Solid phase methods for the identification of an analyte in a biological medium, such as a body fluid, using bioluminescence are provided. A chip designed for performing the method and detecting the bioluminescence is also provided. Methods employing biomineralization for depositing silicon on a matrix support are also provided. A synthetic synapse is also provided.

US Patent:

6682899, Jan 27, 2004

Filed:

Apr 19, 2002

Appl. No.:

10/126777

Inventors:

Bruce J. Bryan - Beverly Hills CA
Stephen Gaalema - Colorado Springs CO
Randall B. Murphy - Irvington NY

Assignee:

Prolume, Ltd. - Beverly Hills CA

International Classification:

G01N 3353

US Classification:

435 71, 435 4, 435 6, 435 79, 435 792, 4352831, 4352887, 435808, 435973, 435975, 436164, 436172, 436518, 436524, 436527, 436805, 422 57, 422 58, 422 681, 422 8205, 422 8208, 356215, 356222, 356317, 427 8, 427162, 427167

Abstract:

Solid phase methods for the identification of an analyte in a biological medium, such as a body fluid, using bioluminescence are provided. A chip designed for performing the method and detecting the bioluminescence is also provided. Methods employing biomineralization for depositing silicon on a matrix support are also provided. A synthetic synapse is also provided.

US Patent:

8431698, Apr 30, 2013

Filed:

Aug 29, 2008

Appl. No.:

12/201680

Inventors:

Philip T. Neff - Golden CO, US
Randall B. Murphy - Glenmoore PA, US
Bruce Bryan - Beverly Hills CA, US

Assignee:

BioLume Inc. - Morrisville NC

International Classification:

C07D 491/00
C07D 495/00
C07D 497/00

US Classification:

544350, 424 96, 435 8

Abstract:

Bioluminescent endoscopy methods and compounds, wherein an anatomical object is examined by means of filling, perfusing, intubating, injecting, or otherwise administering a solution containing a bioluminescent substance or a mixture of luciferin and luciferase which produces bioluminescence, wherein a color or monochrome image of the object is constituted using the images and information based on bioluminescent emitted by the bioluminescent substance. Procedures are demonstrated which allow bioluminescent solutions to be perfused into certain tissue regions, such as but not limited to the common biliary duct, genitourinary tract, gastro-intestinal tract, cardiovascular system and lymphatic system wherein said structures may be conveniently visualized during surgery to avoid damage to these structures. Such images may also be combined with visual light images. Methods of detection of cancer cells using bioluminescence are provided.

US Patent:

20040018983, Jan 29, 2004

Filed:

Dec 20, 2002

Appl. No.:

10/327239

Inventors:

William Rice - Madison CT, US
Douglas Buechter - Wallingford CT, US
Randall Murphy - Irvington NY, US

Assignee:

Achillion Pharmaceuticals, Inc.

International Classification:

A61K038/05
A61K031/198
A61K031/195
C12Q001/18

US Classification:

514/018000, 514/562000, 435/032000

Abstract:

Methods for elucidating an antifungal or anti-yeast compound which selectively bind to a fungal or yeast zinc finger-containing protein within a fungus are disclosed. Assays of screening for compounds that are effective for binding to a fungal or yeast zinc finger-containing protein are also provided. It is also provided a pharmaceutical composition containing an effective amount of a compound or compounds identified as effective for binding to or associating with a fungal or yeast zinc finger-containing protein using the disclosed methods. Fungal and/or yeast infections can be treated or prevented by administering to a patient in need of treatment the pharmaceutical composition containing an effective amount of an compound or compounds identified as effective for binding to or associating with a fungal or yeast zinc finger-containing protein using the disclosed methods.