Randy P Robinson

US Patent:

6652852, Nov 25, 2003

Filed:

Nov 28, 2000

Appl. No.:

09/724138

Inventors:

Randy R. Robinson - Walnut Creek CA
Alvin Y. Liu - Seattle WA
Jeffrey A. Ledbetter - Seattle WA

Assignee:

Royalty Pharma Finance Trust - Wilimington DE

International Classification:

A61K 39395

US Classification:

4241331, 4241531, 4241551, 4241781, 4241821, 4241831, 5303873, 53038873, 5303911, 5303913, 5303917

Abstract:

A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.

US Patent:

6893625, May 17, 2005

Filed:

Aug 1, 2000

Appl. No.:

09/630198

Inventors:

Randy R. Robinson - Mountain View CA, US
Alvin Y. Liu - Bellevue WA, US
Jeffrey A. Ledbetter - Seattle WA, US

Assignee:

Royalty Pharma Finance Trust - Wilmington DE

International Classification:

A61K039/00
C07K016/00

US Classification:

424 149, 424 934, 424 94, 4241331, 4241531, 4241551, 4241781, 4241811, 4241831, 5303873

Abstract:

A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.

US Patent:

20050163708, Jul 28, 2005

Filed:

Sep 15, 2004

Appl. No.:

10/941768

Inventors:

Randy Robinson - Walnut Creek CA, US
Alvin Liu - Seattle WA, US
Jeffrey Ledbetter - Seattle WA, US

International Classification:

A61K051/00
C07H021/04
C12P021/04
A61K039/395

US Classification:

424001490, 424009600, 435069100, 435328000, 435320100, 435252300, 530387300, 424133100, 536023530

Abstract:

A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.

US Patent:

20100055098, Mar 4, 2010

Filed:

Aug 28, 2009

Appl. No.:

12/549501

Inventors:

Randy R. Robinson - Mountain View CA, US

Assignee:

FACET BIOTECH CORPORATION - Redwood City CA

International Classification:

A61K 39/395

US Classification:

4241331, 4241581

Abstract:

Methods are disclosed for using anti-IL-2R antibodies for the treatment of MS patients. In certain embodiments, the patients have neutralizing antibodies to IFN-beta.

US Patent:

56771800, Oct 14, 1997

Filed:

Jun 6, 1995

Appl. No.:

8/469916

Inventors:

Randy R. Robinson - Walnut Creek CA
Alvin Y. Liu - Seattle WA
Jeffrey A. Ledbetter - Seattle WA

Assignee:

Xoma Corporation - Berkeley CA

International Classification:

C12N 119
C12N 520
C12N 1513

US Classification:

435328

Abstract:

The present invention relates to a eukaryotic host cell that contains DNA encoding a chimeric antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a variable region and a human constant region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention is also related to methods of producing the antibody.

US Patent:

62040235, Mar 20, 2001

Filed:

Jun 6, 1995

Appl. No.:

8/472691

Inventors:

Randy R. Robinson - Mountain View CA
Alvin Y. Liu - Bellevue WA
Arnold H. Horwitz - Los Angeles CA
Marc Better - Los Angeles CA
Randolph Wall - Sherman Oaks CA
Gary L. Wilcox - Mill Creek WA

Assignee:

XOMA Ltd.

International Classification:

A61K 39395
C07K 1600
C12P 1934

US Classification:

435 713

Abstract:

The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts tansformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant region modules and non-human variable region modules, or for class switching antibody molecules and/or chains. The invention also relates to DNA coding for pectate lyase signal peptide has been cloned on a plasmid to create a secretion vector which is capable of producing a chosen protein which is transported across the bacterial membrane. The secretion vector has been used to secrete extracellular thaumatin and extracellular chimeric antibody fragments. The proteins produced by this vector have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells.

US Patent:

55761950, Nov 19, 1996

Filed:

Dec 9, 1994

Appl. No.:

8/357234

Inventors:

Randy R. Robinson - Walnut Creek CA
Marc Better - Los Angeles CA
Gary L. Wilcox - Mill Creek WA

Assignee:

Xoma Corporation - Berkeley CA

International Classification:

C12P 2100
C12N 1531
C12N 1562
C12N 121

US Classification:

435 698

Abstract:

The invention relates to DNA coding for a pectate lyase signal peptide which has been inserted into plasmids to create secretion vectors which are capable of producing a chosen protein by directing transport across the bacterial membrane. The secretion vectors have been used to secrete extracellular thaumatin and extracellular antibody fragments. The proteins produced by these vectors have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells.

US Patent:

61207675, Sep 19, 2000

Filed:

Feb 12, 1998

Appl. No.:

9/021934

Inventors:

Randy R. Robinson - Walnut Creek CA
Alvin Y. Liu - Seattle WA
Jeffrey A. Ledbetter - Seattle WA

Assignee:

Pharmaceutical Royalties, L.L.C. - New York NY
Bioventure Investments, kft

International Classification:

A61K 39395
C07K 1630

US Classification:

4241331

Abstract:

A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.