Randy L Robinson

US Patent:

6461824, Oct 8, 2002

Filed:

Jun 6, 1995

Appl. No.:

08/467142

Inventors:

Marc D. Better - Los Angeles CA
Arnold H. Horwitz - Los Angeles CA
Randy R. Robinson - Los Angeles CA
Changtung Paul Chang - Chatsworth CA

Assignee:

Xoma Technology Ltd. - Hamilton

International Classification:

A61K 39395

US Classification:

435 723, 424 149, 424 934, 4241331, 4241781, 435 696, 5303873, 5303911, 5303913, 5303917

Abstract:

The invention is directed to chimeric immunoglobulins that recognize a human tumor antigen bound by antibody, ING-2, ING-3, ING-4 or KM10, the production of such chimeric immunoglobulins, and their use.

US Patent:

6652852, Nov 25, 2003

Filed:

Nov 28, 2000

Appl. No.:

09/724138

Inventors:

Randy R. Robinson - Walnut Creek CA
Alvin Y. Liu - Seattle WA
Jeffrey A. Ledbetter - Seattle WA

Assignee:

Royalty Pharma Finance Trust - Wilimington DE

International Classification:

A61K 39395

US Classification:

4241331, 4241531, 4241551, 4241781, 4241821, 4241831, 5303873, 53038873, 5303911, 5303913, 5303917

Abstract:

A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.

US Patent:

6893625, May 17, 2005

Filed:

Aug 1, 2000

Appl. No.:

09/630198

Inventors:

Randy R. Robinson - Mountain View CA, US
Alvin Y. Liu - Bellevue WA, US
Jeffrey A. Ledbetter - Seattle WA, US

Assignee:

Royalty Pharma Finance Trust - Wilmington DE

International Classification:

A61K039/00
C07K016/00

US Classification:

424 149, 424 934, 424 94, 4241331, 4241531, 4241551, 4241781, 4241811, 4241831, 5303873

Abstract:

A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.

US Patent:

20030096343, May 22, 2003

Filed:

Jan 9, 2002

Appl. No.:

10/040945

Inventors:

Randy Robinson - Los Angeles CA, US
Alvin Liu - Oceanside CA, US
Arnold Horwitz - Los Angeles CA, US
Marc Better - Los Angeles CA, US
Randolph Wall - Sherman Oaks CA, US
Gary Wilcox - Malibu CA, US

Assignee:

XOMA Technology Ltd.

International Classification:

C12P021/02
C07H021/04
C12N005/06
C07K016/40

US Classification:

435/069100, 435/320100, 530/388260, 435/338000, 536/023530

Abstract:

The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts transformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant region modules and non-human variable region modules, or for class switching antibody molecules and/or chains. The invention also relates to DNA coding for pectate lyase signal peptide has been cloned on a plasmid to create a secretion vector which is capable of producing a chosen protein which is transported across the bacterial membrane. The secretion vector has been used to secrete extracellular thaumatin and extracellular chimeric antibody fragments. The proteins produced by this vector have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells. The invention also relates to the secretion of chimeric antibodies and fragments thereof from yeast in functional form.

US Patent:

20050163708, Jul 28, 2005

Filed:

Sep 15, 2004

Appl. No.:

10/941768

Inventors:

Randy Robinson - Walnut Creek CA, US
Alvin Liu - Seattle WA, US
Jeffrey Ledbetter - Seattle WA, US

International Classification:

A61K051/00
C07H021/04
C12P021/04
A61K039/395

US Classification:

424001490, 424009600, 435069100, 435328000, 435320100, 435252300, 530387300, 424133100, 536023530

Abstract:

A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.

US Patent:

20050196400, Sep 8, 2005

Filed:

Oct 3, 2002

Appl. No.:

10/263182

Inventors:

Marc Better - Los Angeles CA, US
Arnold Horwitz - Los Angeles CA, US
Randy Robinson - Los Angeles CA, US
Changtung Chang - Chatsworth CA, US

International Classification:

G01N033/574
A61K039/395
C07K016/30
C12N015/86

US Classification:

424155100, 435456000, 435325000, 435320100, 530388800, 435007230

Abstract:

Gene expression elements and their use in production of chimeric antibodies with human constant regions and murine variable regions, and mouse human chimeric antibodies having specificity to human tumor cells, methods of their production, and their use.

US Patent:

20100055098, Mar 4, 2010

Filed:

Aug 28, 2009

Appl. No.:

12/549501

Inventors:

Randy R. Robinson - Mountain View CA, US

Assignee:

FACET BIOTECH CORPORATION - Redwood City CA

International Classification:

A61K 39/395

US Classification:

4241331, 4241581

Abstract:

Methods are disclosed for using anti-IL-2R antibodies for the treatment of MS patients. In certain embodiments, the patients have neutralizing antibodies to IFN-beta.

US Patent:

56771800, Oct 14, 1997

Filed:

Jun 6, 1995

Appl. No.:

8/469916

Inventors:

Randy R. Robinson - Walnut Creek CA
Alvin Y. Liu - Seattle WA
Jeffrey A. Ledbetter - Seattle WA

Assignee:

Xoma Corporation - Berkeley CA

International Classification:

C12N 119
C12N 520
C12N 1513

US Classification:

435328

Abstract:

The present invention relates to a eukaryotic host cell that contains DNA encoding a chimeric antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a variable region and a human constant region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention is also related to methods of producing the antibody.