Dr. Robinson graduated from the Medical College of Wisconsin School of Medicine in 1985. He works in Clinton, IA and specializes in Family Medicine. Dr. Robinson is affiliated with Mercy Medical Center Clinton.
A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.
Chimeric Antibody With Specificity To Human B Cell Surface Antigen
A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.
Chimeric Antibody With Specificity To Human B Cell Surface Antigen
Randy R. Robinson - Walnut Creek CA Alvin Y. Liu - Seattle WA Jeffrey A. Ledbetter - Seattle WA
Assignee:
Xoma Corporation - Berkeley CA
International Classification:
C12N 119 C12N 520 C12N 1513
US Classification:
435328
Abstract:
The present invention relates to a eukaryotic host cell that contains DNA encoding a chimeric antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a variable region and a human constant region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention is also related to methods of producing the antibody.
Randy R. Robinson - Walnut Creek CA Marc Better - Los Angeles CA Gary L. Wilcox - Mill Creek WA
Assignee:
Xoma Corporation - Berkeley CA
International Classification:
C12P 2100 C12N 1531 C12N 1562 C12N 121
US Classification:
435 698
Abstract:
The invention relates to DNA coding for a pectate lyase signal peptide which has been inserted into plasmids to create secretion vectors which are capable of producing a chosen protein by directing transport across the bacterial membrane. The secretion vectors have been used to secrete extracellular thaumatin and extracellular antibody fragments. The proteins produced by these vectors have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells.
Chimeric Antibody With Specificity To Human B Cell Surface Antigen
Randy R. Robinson - Walnut Creek CA Alvin Y. Liu - Seattle WA Jeffrey A. Ledbetter - Seattle WA
Assignee:
Pharmaceutical Royalties, L.L.C. - New York NY Bioventure Investments, kft
International Classification:
A61K 39395 C07K 1630
US Classification:
4241331
Abstract:
A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.
Chimeric Antibody With Specificity To Human B Cell Surface Antigen
Randy R. Robinson - Walnut Creek CA Alvin Y. Liu - Seattle WA Jeffrey A. Ledbetter - Seattle WA
Assignee:
XOMA Corporation - Berkeley CA
International Classification:
A61K 33395 C07K 1630 G01N 33574
US Classification:
435 723
Abstract:
The present invention relates to a chimeric antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a variable region and a human constant region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention is also related to methods of use for such antibody.