Randy E Robinson

US Patent:

6461824, Oct 8, 2002

Filed:

Jun 6, 1995

Appl. No.:

08/467142

Inventors:

Marc D. Better - Los Angeles CA
Arnold H. Horwitz - Los Angeles CA
Randy R. Robinson - Los Angeles CA
Changtung Paul Chang - Chatsworth CA

Assignee:

Xoma Technology Ltd. - Hamilton

International Classification:

A61K 39395

US Classification:

435 723, 424 149, 424 934, 4241331, 4241781, 435 696, 5303873, 5303911, 5303913, 5303917

Abstract:

The invention is directed to chimeric immunoglobulins that recognize a human tumor antigen bound by antibody, ING-2, ING-3, ING-4 or KM10, the production of such chimeric immunoglobulins, and their use.

US Patent:

20030096343, May 22, 2003

Filed:

Jan 9, 2002

Appl. No.:

10/040945

Inventors:

Randy Robinson - Los Angeles CA, US
Alvin Liu - Oceanside CA, US
Arnold Horwitz - Los Angeles CA, US
Marc Better - Los Angeles CA, US
Randolph Wall - Sherman Oaks CA, US
Gary Wilcox - Malibu CA, US

Assignee:

XOMA Technology Ltd.

International Classification:

C12P021/02
C07H021/04
C12N005/06
C07K016/40

US Classification:

435/069100, 435/320100, 530/388260, 435/338000, 536/023530

Abstract:

The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts transformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant region modules and non-human variable region modules, or for class switching antibody molecules and/or chains. The invention also relates to DNA coding for pectate lyase signal peptide has been cloned on a plasmid to create a secretion vector which is capable of producing a chosen protein which is transported across the bacterial membrane. The secretion vector has been used to secrete extracellular thaumatin and extracellular chimeric antibody fragments. The proteins produced by this vector have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells. The invention also relates to the secretion of chimeric antibodies and fragments thereof from yeast in functional form.

US Patent:

20050196400, Sep 8, 2005

Filed:

Oct 3, 2002

Appl. No.:

10/263182

Inventors:

Marc Better - Los Angeles CA, US
Arnold Horwitz - Los Angeles CA, US
Randy Robinson - Los Angeles CA, US
Changtung Chang - Chatsworth CA, US

International Classification:

G01N033/574
A61K039/395
C07K016/30
C12N015/86

US Classification:

424155100, 435456000, 435325000, 435320100, 530388800, 435007230

Abstract:

Gene expression elements and their use in production of chimeric antibodies with human constant regions and murine variable regions, and mouse human chimeric antibodies having specificity to human tumor cells, methods of their production, and their use.

US Patent:

55003621, Mar 19, 1996

Filed:

Mar 5, 1991

Appl. No.:

7/665939

Inventors:

Randy R. Robinson - Los Angeles CA
Alvin Y. Liu - Santa Monica CA
Jeffrey A. Ledbetter - Seattle WA

Assignee:

XOMA Corporation - Berkeley CA

International Classification:

A61K 39395
C07K 1630
G01N 33574

US Classification:

435 723

Abstract:

The present invention relates to a chimeric IgG1 antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a human constant region and a variable region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention also relates to the increased ADCC and CDC cytolytic activities of the chimeric antibody, methods of production by recombinant DNA techniques, and uses.

US Patent:

56189206, Apr 8, 1997

Filed:

Apr 29, 1994

Appl. No.:

8/235225

Inventors:

Randy R. Robinson - Los Angeles CA
Alvin Y. Liu - Oceanside CA
Arnold H. Horwitz - Los Angeles CA
Marc Better - Los Angeles CA
Randolph Wall - Sherman Oaks CA
Gary L. Wilcox - Malibu CA

Assignee:

Xoma Corporation - Berkeley CA

International Classification:

A61K 39395
C12N 1513
C12N 121

US Classification:

5303871

Abstract:

The invention relates to the secretion of heavy chain immunoglobulin fragments and light chain immunoglobulins from prokaryotic hosts using a prokaryotic secretion signal peptide wherein the heavy chain fragments and light chains are capable of associating to form an antigen binding antibody fragment.

US Patent:

55761844, Nov 19, 1996

Filed:

Dec 27, 1994

Appl. No.:

8/364001

Inventors:

Marc D. Better - Los Angeles CA
Arnold H. Horwitz - Los Angeles CA
Randy R. Robinson - Los Angeles CA
Changtung P. Chang - Chatsworth CA

Assignee:

Xoma Corporation - Berkeley CA

International Classification:

G07K 1630
G01N 33574

US Classification:

435 723

Abstract:

Gene expression elements and their use in production of chimeric antibodies with human constant regions and murine variable regions, and mouse human chimeric antibodies having specificity to human tumor cells, methods of their production, and their use.

US Patent:

58436855, Dec 1, 1998

Filed:

Jun 6, 1995

Appl. No.:

8/466034

Inventors:

Marc D. Better - Los Angeles CA
Arnold H. Horwitz - Los Angeles CA
Randy R. Robinson - Los Angeles CA
Changtung Paul Chang - Chatsworth CA

Assignee:

Xoma Corporation - Berkeley CA

International Classification:

A61K 39395
V07K 1630
G01N 33574

US Classification:

435 723

Abstract:

The invention is directed to a chimeric immunoglobulin that recognizes the human tumor antigen bound by antibody ING-1, its production, and use.

US Patent:

56984170, Dec 16, 1997

Filed:

Jun 6, 1995

Appl. No.:

8/466203

Inventors:

Randy R. Robinson - Los Angeles CA
Alvin Y. Liu - Oceanside CA
Arnold H. Horwitz - Los Angeles CA
Marc Better - Los Angeles CA
Randolph Wall - Sherman Oaks CA
Gary L. Wilcox - Malibu CA

Assignee:

Xoma Corporation - Berkeley CA

International Classification:

C12N 1500
C12N 500
C12P 2106
C12P 2104

US Classification:

435 691

Abstract:

The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts transformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant region modules and non-human variable region modules, or for class switching antibody molecules and/or chains. The invention also relates to DNA coding for pectate lyase signal peptide has been cloned on a plasmid to create a secretion vector which is capable of producing a chosen protein which is transported across the bacterial membrane. The secretion vector has been used to secrete extracellular thaumatin and extracellular chimeric antibody fragments. The proteins produced by this vector have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells.