Raymond F Gibson

US Patent:

6458935, Oct 1, 2002

Filed:

Jun 12, 2000

Appl. No.:

09/668637

Inventors:

H. Donald Burns - Harleysville PA
Terence G. Hamill - Lansdale PA
Raymond E. Gibson - Holland PA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D40304

US Classification:

534 10, 544370, 558414

Abstract:

The present invention is directed toward radiolabeled farnesyl-protein transferase inhibitor compounds which are useful to label FPTase in assays, whether cell-based, tissue-based or in whole animal. The tracers can also be used in competitive binding assays to obtain information on the interaction of unlabeled FTIs with FPTase.

US Patent:

6939966, Sep 6, 2005

Filed:

Jul 19, 2002

Appl. No.:

10/484551

Inventors:

H. Donald Burns - Harleysville PA, US
Raymond E. Gibson - Holland PA, US
Terence G. Hamill - Lansdale PA, US
Takehiro Fukami - Hanamuro, JP

Assignee:

Merck & Co., Inc. - Rahway NJ
Banyu Pharmaceutical Co., Ltd.

International Classification:

C07D491/10
A61K049/00
A61K051/00

US Classification:

544331, 546 16, 424 181, 424 185, 424 189, 424 92

Abstract:

The present invention is directed to radiolabeled neuropeptide Y Y5 receptor antagonists which are useful for the labeling and diagnostic imaging of neuropeptide Y Y5 receptors in mammals.

US Patent:

7354935, Apr 8, 2008

Filed:

Sep 19, 2003

Appl. No.:

10/528888

Inventors:

H. Donald Burns - Harleysville PA, US
Wai-si Eng - Maple Glen PA, US
Raymond E. Gibson - Holland PA, US
Terence G. Hamill - Lansdale PA, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/445
C07D 401/12

US Classification:

514326, 546201

Abstract:

The present invention is directed to radiolabeled neurokinin-1 receptor antagonists which are useful for the labeling and diagnostic imaging of neurokinin-1 receptors in mammals.

US Patent:

7754188, Jul 13, 2010

Filed:

Jun 25, 2004

Appl. No.:

10/559228

Inventors:

H. Donald Burns - Harleysville PA, US
Alex M. Chen - Cranford NJ, US
Raymond E. Gibson - Holland PA, US
Mark T. Goulet - Westfield NJ, US
William K. Hagmann - Westfield PA, US
Terence G. Hamill - Lansdale PA, US
James P. Jewell - Jersey City NJ, US
Linus S. Lin - Westfield NJ, US
Ping Liu - Westfield NJ, US
Andrey V. Peresypkin - Cranford NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 165, 424 189

Abstract:

The present invention relates to particular radiolabeled Cannabinoid-1 (CB1) receptor modulators, and methods of using these modulators for labeling and diagnostic imaging of Cannabinoid-1 receptors in mammals, particularly humans. In addition, intermediates useful for the synthesis of the radiolabeled Cannabinoid-1 receptor modulators are also disclosed, as well as the processes for synthesizing the radiolabeled Cannabinoid-1 receptor modulators. Still further, formulations of the radiolabeled Cannabinoid-1 receptor compounds are described.

US Patent:

62419641, Jun 5, 2001

Filed:

Sep 28, 1999

Appl. No.:

9/407822

Inventors:

H. Donald Burns - Harleysville PA
Terence G. Hamill - Lansdale PA
Raymond E. Gibson - Holland PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 5100
C07D40100
C07D21156
G01N 3353
G01N 33534

US Classification:

424 189

Abstract:

The present invention is directed to radiolabeled neurokinin-1 receptor antagonists which are useful for the labeling and diagnostic imaging of neurokinin-1 receptors in mammals.

US Patent:

60600381, May 9, 2000

Filed:

May 7, 1998

Appl. No.:

9/074346

Inventors:

Hugh D. Burns - Harleysville PA
Wai-Si Eng - Maple Glen PA
Raymond E. Gibson - Holland PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 5104
C07D24100

US Classification:

424 181

Abstract:

The present invention is directed toward radiolabeled farnesyl-protein transferase inhibitor compounds which are useful to label FPTase in assays, whether cell-based, tissue-based or in whole animal. The tracers can also be used in competitive binding assays to obtain information on the interaction of unlabeled FTIs with FPTase.

US Patent:

49942581, Feb 19, 1991

Filed:

Mar 5, 1990

Appl. No.:

7/488192

Inventors:

H. Donald Burns - Harleysville PA
Nancy J. Brenner - Macungie PA
Raymond E. Gibson - Holland PA
Howard F. Solomon - New Hope PA

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 4902
C07D24324

US Classification:

424 11

Abstract:

Novel radiolabeled cholecystokinin-A (CCK-A) antagonists have been developed which, after intravenous injection, localize in the pancreas as a result of specific binding to CCK-A receptors. These tracers, when labeled with appropriate radiohalogens, are useful as commercial diagnostic imaging radiopharmaceuticals and radiotherapeutic drugs.