Raymond D Youssefyeh

US Patent:

53170156, May 31, 1994

Filed:

May 1, 1992

Appl. No.:

7/877574

Inventors:

John W. Ullrich - Philadelphia PA
Raymond D. Youssefyeh - Princeton Junction NJ
Daniel L. Cheney - Audubon PA
Christopher J. Burns - Bryn Mawr PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA

International Classification:

A61K 31675
A61K 3166

US Classification:

514 79

Abstract:

This invention relates to a method of lowering abnormally high serum cholesterol levels in the body without significantly reducing mevalonic metabolite synthesis and to novel pharmacological compositions containing as an active ingredient bisphosphonic acid and ester compounds containing a mono-, bi- or tricyclic ring linked with a bisphosphonate moiety through a basic amino alkylene group. This invention also provides novel bisphosphonate compounds and the processes for their preparation.

US Patent:

49240102, May 8, 1990

Filed:

Jul 31, 1989

Appl. No.:

7/351685

Inventors:

Raymond Youssefyeh - Princeton Junction NJ
Scott I. Klein - Audubon PA
Henry F. Campbell - North Wales PA
Donald E. Kuhla - Doylestown PA

Assignee:

Rorer Pharmaceutical Corporation - Ft. Washington PA

International Classification:

C07D31308

US Classification:

549355

Abstract:

Certain specific substituted 9-N-(1-azabicycolo-[2. 2. 2. ]octan-3-yl)carboxamido-2,3,4,5-tetrahydro-1-ben zoxepins and their valuable use as 5-HT. sub. 3 antagonists having CNS and gastric prokinetic activity and void of any significant D. sub. 2 receptor binding properties are disclosed. Methods for their preparation also are described.

US Patent:

46199446, Oct 28, 1986

Filed:

Feb 19, 1985

Appl. No.:

6/703054

Inventors:

Raymond D. Youssefyeh - Tarrytown NY
Howard Jones - Holmdel NJ

Assignee:

USV Pharmaceutical Corporation - Fort Washington PA

International Classification:

A61K 31265
A61K 31275
A61K 31215
A61K 3124

US Classification:

514513

Abstract:

Provided are antihypertensive compounds of the formula ##STR1## wherein R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 4, R. sub. 5, and R. sub. 6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl, and may be the same or different, m is an integer from 0 to 2 inclusive, n is an integer from 0 to 4 inclusive, M is alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cycloalkyl, hetero-cycloalkyl-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, fused heteroaryl-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, or dialkylaminoalkyl. Y is hydroxy, alkoxy, amino, or substituted amino, aminoalkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, and R. sub. 7 is alkyl, aryl, aralkyl, cycloalkyl, cycloalkyl-alkyl, heterocyclic, --CO--SR, --CS--SR, ##STR2## CH. sub. 2 CO. sub.

US Patent:

48596833, Aug 22, 1989

Filed:

Feb 4, 1988

Appl. No.:

7/152192

Inventors:

Raymond Youssefyeh - Princeton Junction NJ
Scott I. Klein - Audubon PA
Henry F. Campbell - North Wales PA
Donald E. Kuhla - Doylestown PA

Assignee:

Rorer Pharmaceutical Corporation - Fort Washington PA

International Classification:

A61K 3144
C07D47108

US Classification:

514299

Abstract:

Certain specific substituted 9-N-(1-azabicyclo[3. 3. 1. ]nonan-4-yl)carboxamido-2,3,4,5-tetrahydro-1-benzo xepins and their valuable use as 5-HT. sub. 3 antagonists having CNS and gastric prokinetic activity and void of any significant D. sub. 2 receptor binding properties are disclosed. Methods for their preparation also are described.

US Patent:

49594850, Sep 25, 1990

Filed:

May 15, 1989

Appl. No.:

7/351625

Inventors:

Raymond D. Youssefyeh - Princeton Junction NJ
Henry F. Campbell - North Wales PA
Donald E. Kuhla - Doylestown PA

Assignee:

Rorer Pharmaceutical Corporation - Fort Washington PA

International Classification:

C07D30791

US Classification:

549461

Abstract:

This invention is directed to certain dibenzofurancarboxamides and their use as 5HT. sub. 3 antagonists having unique CNS, anti-emetic and gastric prokinetic activity void of any significant D. sub. 2 receptor binding properties. This invention also describes novel processes necessary for their preparation.

US Patent:

50861794, Feb 4, 1992

Filed:

Sep 24, 1990

Appl. No.:

7/586669

Inventors:

Matthew R. Powers - Barto PA
Raymond D. Youssefyeh - Princeton Junction NJ
William L. Studt - Harleysville PA
Frederick A. Golec - Merion PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Ft. Washington PA

International Classification:

C07D45302
C07B 5300
C07C23108

US Classification:

546133

Abstract:

This invention is directed to certain dibenzofurancarboxamides and dibenzofurancarboxamide acids and their use as 5HT. sub. 3 antagonists having unique CNS, anti-emetic and gastric prokinetic activity void of any significant D. sub. 2 receptor binding properties. Further, this invention relates to a process for the synthesis of stereoisomeric compounds having such CNS, anti-emetic and gastric prokinetic activity.

US Patent:

44965427, Jan 29, 1985

Filed:

Apr 13, 1983

Appl. No.:

6/484729

Inventors:

Jerry W. Skiles - Tuckahoe NY
Raymond D. Youssefyeh - Tarrytown NY
John T. Suh - Greenwich CT
Howard Jones - Ossining NY

Assignee:

USV Pharmaceutical Corporation - Tarrytown NY

International Classification:

A61K 3700
A61K 3140
A61K 31425
C07C10352
C07D40300
C07D23366
C07D23328
C07D23300
C07D23504
C07D40500
C07D21172
C07D21156
C07D21130
C07D21500
C07D22102
C07D41500
C07D41300
C07D26530
C07D27910

US Classification:

514 2

Abstract:

Compounds of the formula ##STR1## wherein R and R. sub. 9 are independently hydroxy and lower alkoxy, R. sub. 1 and R. sub. 2 are independently hydrogen, lower alkyl, aryl-lower alkyl having from 7 to 12 carbon atoms, or heterocyclic-lower alkyl having from 6 to 12 carbon atoms, R. sub. 3, R. sub. 4, R. sub. 5, R. sub. 7 and R. sub. 8 are hydrogen or lower alkyl, R. sub. 6 is heterocyclic and their pharmaceutically acceptable, nontoxic acid addition salts and where R or R. sub. 9 or both are hydroxy, their pharmaceutically acceptable, nontoxic basic salts, possess antihypertensive activity.

US Patent:

50632302, Nov 5, 1991

Filed:

Apr 6, 1990

Appl. No.:

7/489646

Inventors:

Jeffrey C. Pelletier - Lansdale PA
Raymond D. Youssefyeh - Princeton Junction NJ
Henry F. Campbell - North Wales PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Ft. Washington PA

International Classification:

A61K 3146
A61K 31435

US Classification:

514213

Abstract:

This invention relates to a series of bicyclic benzomonoazacyclic carboxamide compounds of the general formula: ##STR1## Where Z is tertiary amine, which are useful for the method of treating patients suffering from gastrointestinal disorders, and of pharmaceutical composition including an effective 5HT3 - antagonists amount of said compounds therein.