Rebecca Lynn Li

US Patent:

6627422, Sep 30, 2003

Filed:

Dec 21, 2000

Appl. No.:

09/673339

Inventors:

Rebecca Li - Bedford MA
David Rhein - Cambridge MA

Assignee:

Neurotech S.A. - Evry

International Classification:

C12N 1104

US Classification:

435182, 424423, 424424, 424 937, 435382, 435395, 435396, 435397, 435398, 435402

Abstract:

A device is provided containing cells or tissue distributed on a filamentous cell-supporting matrix which is encapsulated by a semi-permeable membrane which can be immunoisolatory. The matrix may be formed of a plurality of monofilaments twisted into yarn that is in non-woven strands, or of the monofilaments or yarn woven into a mesh. Configurations of the matrix include a hollow cylinder, tube, solid cylinder or cord. A coating of extracellular matrix molecules may be on the matrix, or the matrix may be treated with plasma irradiation to enhance cell adhesion. The device can be made by inserting the matrix in a hollow membrane tube, injecting cells or tissue into the tube and sealing ends of the tube. The device is particularly useful for implantation into a mammalian host to provide therapy resulting from a biologically active molecule produced by the cells and tissue.

US Patent:

7189392, Mar 13, 2007

Filed:

Oct 13, 2000

Appl. No.:

09/687281

Inventors:

Hyun Kim - Middleton MA, US
Rebecca Li - Bedford MA, US
Alessandra Pavesio - Padua, IT
Lanfranco Callegaro - Thiene, IT
Howard Seeherman - Cambridge MA, US
John Wozney - Hudson MA, US

Assignee:

Genetics Institute, LLC - Cambridge MA
Fidia Advanced Biopolymers S.R.L. - Abano Terme

International Classification:

A61K 38/43

US Classification:

424 941

Abstract:

An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.

US Patent:

7413753, Aug 19, 2008

Filed:

May 31, 2002

Appl. No.:

10/160607

Inventors:

Rebecca H. Li - Bedford MA, US
Howard Seeherman - Cambridge MA, US

Assignee:

Wyeth - Madison NJ
Etex Corporation - Cambridge MA

International Classification:

A61K 33/42
A61K 9/14
A61K 9/50
A61K 33/00
A61K 38/00

US Classification:

424602, 424484, 424486, 424494, 424717, 514 2

Abstract:

A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.

US Patent:

7608580, Oct 27, 2009

Filed:

Jan 18, 2007

Appl. No.:

11/624463

Inventors:

Hyun Kim - Middleton MA, US
Rebecca Li - Bedford MA, US
Alessandra Pavesio - Padua, IT
Lanfranco Callegaro - Thiene, IT
Howard Seeherman - Cambridge MA, US
John Wozney - Hudson MA, US

Assignee:

Genetics Institute, LLC - Cambridge MA
Fidia Advanced Biopolymers S.R.L. - Abano Terme, Padua

International Classification:

A61K 38/16

US Classification:

514 2

Abstract:

An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.

US Patent:

7622139, Nov 24, 2009

Filed:

Dec 17, 2007

Appl. No.:

11/957691

Inventors:

Rebecca Li - Bedford MA, US
Howard Seeherman - Cambridge MA, US
Aliassghar Tofighi - Waltham MA, US

Assignee:

Wyeth - Madison NJ
ETEX Corporation - Cambridge MA

International Classification:

A61K 33/42
A61K 33/02

US Classification:

424601, 424717

Abstract:

A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.

US Patent:

7771755, Aug 10, 2010

Filed:

Sep 10, 2004

Appl. No.:

10/937364

Inventors:

Rebecca Li - Bedford MA, US
Howard Seeherman - Cambridge MA, US
Hyun Kim - Bedford MA, US

Assignee:

Wyeth - Madison NJ
Etex Corporation - Cambridge MA

International Classification:

A61K 38/23
A61K 33/42

US Classification:

424602, 424499, 514 12, 530350

Abstract:

Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed.

US Patent:

7875590, Jan 25, 2011

Filed:

Mar 31, 2009

Appl. No.:

12/414715

Inventors:

Rebecca H. Li - Bedford MA, US
Hyun D. Kim - Bedford MA, US

Assignee:

Wyeth - Madison NJ
Fidia Advanced Biopolymers, S.R.L. - Padua

International Classification:

A61K 38/00
A61F 2/28

US Classification:

514 167, 424426

Abstract:

Methods of using an injectable or implantable rod-shaped formulation for delivery of osteogenic proteins to treat osteoporotic and/or osteopenic bone are disclosed. The formulation comprises hyaluronic acid derivatives and osteogenic proteins, and optional excipients and active ingredients such as a bone resorption inhibitor.

US Patent:

8003133, Aug 23, 2011

Filed:

Sep 23, 2009

Appl. No.:

12/565159

Inventors:

Rebecca Li - Bedford MA, US
Howard Seeherman - Cambridge MA, US
Aliassghar Tofighi - Waltham MA, US

Assignee:

Wyeth LLC - Madison NJ
Etex Corporation - Cambridge MA

International Classification:

A61K 33/42
A61K 33/00

US Classification:

424601, 424717

Abstract:

A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.