Rebecca J Miller

US Patent:

20090046832, Feb 19, 2009

Filed:

Aug 15, 2008

Appl. No.:

12/192762

Inventors:

Eva R. Birnbaum - Los Alamos NM, US
Benjamin P. Warner - Los Alamos NM, US
Sharon M. Baldwin - Santa Fe NM, US
Jennifer A. Berger - Los Alamos NM, US
Rebecca L.E. Miller - Los Alamos NM, US

Assignee:

Caldera Pharmaceuticals, Inc. - Los Alamos NM

International Classification:

G01N 23/223

US Classification:

378 45

Abstract:

The present invention includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays. The present invention also includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered on one side of the plate by a detachable cover forming a water-tight seal against the plate. The cover is substantially free of the elements osmium, yttrium, iridium, phosphorus, zirconium, platinum, gold, niobium, mercury, thallium, molybdenum, sulfur, lead, bismuth, technetium, ruthenium, chlorine, rhodium, palladium, argon, silver, and thorium. The holes are less than about 500 micrometers across in one dimension where the cover covers the holes. The present invention also includes a method for preparing samples for measurement by x-ray fluorescence spectrometry. The method comprises providing a solution of with less than 10 micromolar solute and a volume of between about 2 microliters and about 2 milliliters. The solution is concentrated and analyzed using x-ray fluorescence spectrometry.

US Patent:

20090087919, Apr 2, 2009

Filed:

Sep 26, 2008

Appl. No.:

12/239459

Inventors:

Eva R. Birnbaum - Los Alamos NM, US
Benjamin P. Warner - Los Alamos NM, US
Sharon M. Baldwin - Santa Fe NM, US
Jennifer A. Berger - Los Alamos NM, US
Michael N. Harris - Los Alamos NM, US
Rebecca L.E. Miller - Los Alamos NM, US

Assignee:

Caldera Pharmaceuticals, Inc. - Los Alamos NM

International Classification:

G01N 33/00
G01N 21/64

US Classification:

436 86, 436172, 436128, 436106

Abstract:

The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The donor chemical includes a functional group selected from ester, anhydride, imide, acyl halide, and amide. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Yet another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. An additional analytical method is also used to measure either the acceptor product or the donor chemical.

US Patent:

20100003697, Jan 7, 2010

Filed:

Jul 1, 2009

Appl. No.:

12/496532

Inventors:

Eva R. Birnbaum - Los Alamos AZ, US
Rebecca L.E. Miller - Los Alamos NM, US
Lori J. Peterson - Los Alamos NM, US
Jennifer A. Berger - White Rock NM, US
Benjamin P. Warner - Los Alamos NM, US

Assignee:

Caldera Pharmaceuticals, Inc. - Los Alamos NM

International Classification:

G01N 33/53
C12M 1/34

US Classification:

435 71, 4352887

Abstract:

The present invention includes a method and apparatus for measuring the transport of analytes through a cell barrier.

US Patent:

20130034205, Feb 7, 2013

Filed:

Aug 6, 2012

Appl. No.:

13/567613

Inventors:

Eva R. Birnbaum - Los Alamos NM, US
Benjamin P. Warner - Los Alamos NM, US
Sharon M. Baldwin - Santa Fe NM, US
Jennifer A. Berger - Los Alamos NM, US
Rebecca L.E. Miller - Los Alamos NM, US

Assignee:

Caldera Pharmaceuticals, Inc. - Los Almos NM

International Classification:

G01N 1/28
G01N 23/223

US Classification:

378 45, 378208

Abstract:

An apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. A plate has one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays.

US Patent:

20130236887, Sep 12, 2013

Filed:

Apr 26, 2013

Appl. No.:

13/871697

Inventors:

Benjamin P. Warner - Los Alamos NM, US
Rebecca L.E. Miller - Los Alamos NM, US
Lori J. Peterson - Los Alamos NM, US
Jennifer A. Berger - White Rock NM, US
Eva R. Birnhaum - Los Alamos NM, US

Assignee:

Caldera Pharmaceuticals, Inc. - Los Alamos NM

International Classification:

G01N 33/68
G01N 33/50

US Classification:

435 61, 435 29

Abstract:

The present invention includes a method and apparatus for measuring the transport of analytes through a cell barrier.

US Patent:

56030746, Feb 11, 1997

Filed:

Mar 28, 1995

Appl. No.:

8/412384

Inventors:

Rebecca L. Miller - Los Alamos NM
Anthony B. Pinkerton - Santa Fe NM
Kent D. Abney - Los Alamos NM
Scott A. Kinkead - Los Alamos NM

Assignee:

The Regents of the University of California - Los Alamos NM

International Classification:

C01F 1100

US Classification:

423 2

Abstract:

Preparation and use of tetra-C-alkyl cobalt dicarbollide for extraction of cesium and strontium into hydrocarbon solvents. Tetra-C-alkyl derivatives of cobalt dicarbollide, Co(C. sub. 2 R. sub. 2 B. sub. 9 H. sub. 9). sub. 2. sup. - (CoB. sub. 2 R. sub. 4. sup. - ; R=CH. sub. 3 and C. sub. 6 H. sub. 13) are demonstrated to be significant cesium and strontium extractants from acidic and alkaline solutions into non-toxic organic solvent systems. Extractions using mesitylene and diethylbenzene are compared to those with nitrobenzene as the organic phase. CoB. sub. 2 -hexyl. sub. 4. sup. - in diethylbenzene shows improved selectivity (10. sup. 4) for Cs over Na in acidic solution. In dilute alkaline solution, CoB. sub. 2 -hexyl. sub. 4. sup. - extracts Cs less efficiently, but more effectively removes Sr from higher base concentrations. A general synthesis of tetra-C-alkyl cobalt dicarbollides is described.

US Patent:

20200157598, May 21, 2020

Filed:

Jan 23, 2020

Appl. No.:

16/750144

Inventors:

- Durham NC, US
Benjamin P. WARNER - Los Alamos NM, US
Sharon M. BALDWIN - Santa Fe NM, US
Jennifer A. BERGER - Los Alamos NM, US
Michael N. HARRIS - Los Alamos NM, US
Rebecca L.E. MILLER - Los Alamos NM, US

International Classification:

C12Q 1/48
G01N 33/68
G01N 23/223
G01N 33/20
C12Q 1/37
G01N 21/75

Abstract:

The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The donor chemical includes a functional group selected from ester, anhydride, imide, acyl halide, and amide. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Yet another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. An additional analytical method is also used to measure either the acceptor product or the donor chemical.

US Patent:

20190064182, Feb 28, 2019

Filed:

Aug 22, 2018

Appl. No.:

16/109049

Inventors:

- DURHAM NC, US
Lori J. Peterson - Los Alamos NM, US
Jennifer A. Berger - Los Alamos NM, US
Eva R. Birnbaum - Los Alamos NM, US
Rebecca L.E. Miller - Los Alamos NM, US

Assignee:

ICAGEN, INC. - DURHAM NC

International Classification:

G01N 33/68
G01N 23/223
G01N 23/207
G01N 33/50

Abstract:

The present invention includes a method and apparatus for measuring the transport of analytes through a cell barrier.