This invention generally relates to methods to treat conditions and diseases associated with interleukin-17 (IL-17) production. The invention also relates to methods of inhibiting γδ T cells, and particularly, a subset of γδ T cells that produce IL-17.
Agents And Methods For Inhibition Of Airway Hyperresponsiveness
Rebecca L. O'Brien - Denver CO, US Willi K. Born - Denver CO, US Niyun Jin - Denver CO, US Christina L. Roark - Englewood CO, US
International Classification:
A61K 39/395 A61K 38/17 A61P 11/00
US Classification:
4241301, 514 12, 424 9371
Abstract:
The present invention provides methods and compositions for inhibition of Airway Hyperresponsiveness (“AHR”) by deleting, inactivating or inhibiting a subset of innate γδ T cells, alone or in conjunction with the inhibition of Natural Killer T (“NKT”) cells. The methods comprise selective leukophoresis to remove the γδ T cells from the individual's blood or administration of an agent that selectively targets and inhibits or inactivates the γδ T cells. The methods of the present invention can be used to treat AHR in a variety of different ailments, including allergen-induced conditions or respiratory conditions and diseases.
Healthcare Association of Hawaii
Clinical Improvement Coach
Hhsc Kauai Region May 2009 - Jan 2016
Director of Quality
Kauai Veterans Memorial Hosp St Francis Home Care Services May 1993 - May 2009
Registered Nurse