Rebecca A Wallace

US Patent:

53712781, Dec 6, 1994

Filed:

Mar 25, 1994

Appl. No.:

8/217575

Inventors:

William Z. McCarthy - St. Louis MO
Mills T. Kneller - University City MO
Youlin Lin - Chesterfield MO
Rebecca A. Wallace - Manchester MO
David H. White - Ballwin MO

Assignee:

Mallinckrodt Medical PMC - Las Vegas NV

International Classification:

C07C 6702

US Classification:

560251

Abstract:

The use of a minimal excess of acetoxyacetylchloride as a reagent in the synthesis of N,N'-bis(2,3-dihydroxypropyl)-5-N-(2-hydroxy-ethyl)glycolamido-2,4,6-triio doisophthalamide.

US Patent:

52083756, May 4, 1993

Filed:

Apr 29, 1992

Appl. No.:

7/875503

Inventors:

Dennis A. Moore - Ferguson MO
Rebecca A. Wallace - Manchester MO

Assignee:

Mallinckrodt Medical, Inc. - St. Louis MO

International Classification:

C07C22906

US Classification:

564197

Abstract:

Methods and compositions for enhancing magnetic resonance imaging in at least a portion of a warm-blooded animal.

US Patent:

52177068, Jun 8, 1993

Filed:

Jun 3, 1992

Appl. No.:

7/893157

Inventors:

Raghavan Rajagopalan - Maryland Heights MO
Rebecca A. Wallace - Manchester MO
Muthunadar P. Periasamy - Creve Coeur MO

Assignee:

Mallinckrodt Medical, Inc. - St. Louis MO

International Classification:

G01N 2408
A61K 31555
C07D22500
C07D22300

US Classification:

424 9

Abstract:

Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.

US Patent:

56933088, Dec 2, 1997

Filed:

Feb 21, 1996

Appl. No.:

8/604286

Inventors:

Dennis A. Moore - Ferguson MO
Stephen R. Cooper - St. Louis MO
Rebecca Abernathy Wallace - Manchester MO
Michael R. Hynes - Florissant MO

Assignee:

Mallinckrodt Medical, Inc. - St. Louis MO

International Classification:

A61K 4900
G01N 3100
G01N 3348

US Classification:

424 934

Abstract:

The present invention provides compositions comprising a contrast agent capable of reversibly binding to thiol groups of blood-borne proteins. The compositions of the invention provide increased residence time of the contrast agent in the vasculature, thus providing effective blood pool contrast agents. The invention also provides methods for imaging a patient comprising administering a composition of the invention and obtaining an image.

US Patent:

51380404, Aug 11, 1992

Filed:

Jul 2, 1991

Appl. No.:

7/724653

Inventors:

Dennis A. Moore - Ferguson MO
Rebecca A. Wallace - Manchester MO

Assignee:

Mallinckrodt Medical, Inc. - St. Louis MO

International Classification:

A61K 4900
A61B 505
A61B 600

US Classification:

534 16

Abstract:

Methods and compositions for enhancing magnetic resonance imaging in at least a portion of a warm-blooded animal.

US Patent:

52905373, Mar 1, 1994

Filed:

Feb 12, 1993

Appl. No.:

8/016630

Inventors:

Dennis A. Moore - Ferguson MO
Rebecca A. Wallace - Manchester MO

Assignee:

Mallinckrodt Medical, Inc. - St. Louis MO

International Classification:

A61K 4900

US Classification:

424 9

Abstract:

Methods and compositions for enhancing magnetic resonance imaging in at least a portion of a warm-blooded animal.

US Patent:

51417405, Aug 25, 1992

Filed:

Nov 21, 1990

Appl. No.:

7/616450

Inventors:

Raghavan Rajagopalan - Maryland Heights MO
Rebecca A. Wallace - Manchester MO
Muthunadar P. Periasamy - Creve Coeur MO

Assignee:

Mallinckrodt Medical, Inc. - St. Louis MO

International Classification:

G01N 2400
G01N 3100
A61K 3128
C07F 500

US Classification:

424 9

Abstract:

Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.

US Patent:

53146808, May 24, 1994

Filed:

May 4, 1993

Appl. No.:

8/012185

Inventors:

Raghavan Rajagopalan - Maryland Heights MO
Rebecca A. Wallace - Manchester MO
Muthunadar P. Periasamy - Creve Coeur MO

Assignee:

Mallinckrodt Medical, Inc. - St. Louis MO

International Classification:

A61B 5055
C07D25502

US Classification:

424 9

Abstract:

Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.