Regina Marie Black - Cranford NJ Anthony Brian Jones - Clavering, GB Harold Blair Wood - Cranford NJ
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
A61K 31405
US Classification:
514415, 548510, 548511
Abstract:
Certain N-substituted indoles having aryloxyacetic acid, substituents are agonists or partial agonists of PPAR gamma, and are useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR mediated diseases, disorders and conditions.
Sheryl D. Debenham - Scotch Plains NJ, US Kun Liu - Edison NJ, US Peter T. Meinke - Plainfield NJ, US Harold B. Wood - Westfield NJ, US Regina M. Black - Cranford NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31/40 C07D 209/36
US Classification:
514419, 548484
Abstract:
Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
Sheryl D. Debenham - Scotch Plains NJ, US Kun Liu - Edison NJ, US Peter T. Meinke - Plainfield NJ, US Harold B. Wood - Westfield NJ, US Regina M. Black - Cranford NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31/40 C07D 209/36
US Classification:
514419, 548484
Abstract:
Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
Peter T. Meinke - Plainfield NJ, US Harold B. Wood - Westfield NJ, US Regina M. Black - Cranford NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D 261/20 A01N 43/80
US Classification:
548241, 514379
Abstract:
Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
James M. Balkovec - North Plainfield NJ Regina M. Black - Cranford NJ Frances A. Bouffard - Scotch Plains NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07K 764
US Classification:
530317
Abstract:
Aza cyclohexapeptide compounds are disclosed with a nitrogen attached to the cyclohexapeptide ring at the 5-carbon of the 4-hydroxyornithine component. Such compounds are represented by the formula: ##STR1## The compounds are disclosed as having antifungal, antiprotozoal and anti-Pneumocystis carinii activity.
James M. Balkovec - North Plainfield NJ Frances Aileen Bouffard - Scotch Plains NJ Regina M. Black - Cranford NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3812 C07K 752
US Classification:
514 11
Abstract:
Ceretain aza cyclohexapeptide compounds have been found to have superior antibiotic properties. Novel processes for their preparation are also described.
Process For Reduction Of Certain Cyclohexapeptide Compounds
James M. Balkovec - North Plainfield NJ Regina C. Black - Cranford NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3702 C12P 2104
US Classification:
530317
Abstract:
Process for producing a compound of the formula ##STR1## by selectively reducing a compound of the formula ##STR2## in a strong acid medium with excess molar equivalent of reducing agent so that the OH adjacent to X. sub. 1 is reduced to H and if Q is OH in the starting material, it optionally may be reduced H.
James M. Balkovec - North Plainfield NJ Regina M. Black - Cranford NJ Frances A. Bouffard - Scotch Plains NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3812
US Classification:
514 11
Abstract:
Ceretain aza cyclohexapeptide compounds have been found to have superior antibiotic properties. Novel processes for their preparation are also described.