Reid L Kress

US Patent:

6569687, May 27, 2003

Filed:

Dec 15, 2000

Appl. No.:

09/738821

Inventors:

Mitchel J. Doktycz - Knoxville TN
William Louis Bryan - Knoxville TN
Reid Kress - Oak Ridge TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

G01N 110

US Classification:

436180, 436174, 422100, 7386417, 7386332, 73864, 7386401, 7386402, 7386411

Abstract:

A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.

US Patent:

6627157, Sep 30, 2003

Filed:

Mar 4, 1999

Appl. No.:

09/262455

Inventors:

Mitchel J. Doktycz - Knoxville TN
William Louis Bryan - Knoxville TN
Reid Kress - Oak Ridge TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

B01L 302

US Classification:

422100, 436180, 73864, 7386401, 7386411, 7386402, 7386332, 7386417

Abstract:

A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.

US Patent:

60843713, Jul 4, 2000

Filed:

Feb 19, 1999

Appl. No.:

9/253186

Inventors:

Reid L. Kress - Oak Ridge TN
John F. Jansen - Knoxville TN

Assignee:

Lockheed Martin Energy Research Corporation - Oak Ridge TN

International Classification:

B25J 700

US Classification:

318566

Abstract:

A human de-amplifier system for interfacing a human operator and a physical object through a physical plant, wherein the physical object has dimensions in the range of 1 micrometer to 1 mm. The human de-amplifier system uses an inner-feedback loop to increases the equivalent damping of the operating system to stabilize the system when it contacts with the environment and reduces the impact of the environment variation by utilizing a high feedback gain, determined by a root locus sketch. Because the stability of the human de-amplifier system of the present invention is greatly enhanced over that of the prior art, the de-amplifier system is able to manipulate the physical object has dimensions in the range of 1 micrometer to 1 mm with high stability and accuracy. The system also has a monitoring device to monitor the motion of the physical object under manipulation.