Renato J Aguilera

US Patent:

20080020421, Jan 24, 2008

Filed:

Jul 19, 2007

Appl. No.:

11/780291

Inventors:

Renato Aguilera - El Paso TX, US

International Classification:

C12Q 1/02

US Classification:

435032000

Abstract:

The present invention provides for methods of screening agents for cytotoxic and/or anti-microbial activity. In particular embodiments, the loss of a fluorescent signal from the treated cells, due to cell death or inhibition of growth, is measured for several different cell types in parallel.

US Patent:

6455250, Sep 24, 2002

Filed:

Dec 11, 1998

Appl. No.:

09/210422

Inventors:

Renato J. Aguilera - Culver City CA
Christopher J. Lyon - Los Angeles CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12Q 168

US Classification:

435 6, 435 691, 4353201, 435325, 435455, 435456, 424 932, 424 9321, 536 232, 536 235

Abstract:

Disclosed are methods for modulating apoptosis and altering programmed cell death events using novel Endo-SR gene compositions and the polypeptides encoded thereby. Also disclosed are methods for repairing DNA, modulating genetic recombination in a cell, and altering DNA rearrangement in a host cell. Also disclosed are methods for the design and isolation of peptidomimetics and other inhibitors of Endo-SR useful in the treatment of leukemias, lymphomas, and other cancers.

US Patent:

20210361643, Nov 25, 2021

Filed:

Jun 19, 2019

Appl. No.:

17/041800

Inventors:

- El Paso TX, US
Renato Aguilera - El Paso TX, US

International Classification:

A61K 31/4745
A61K 31/337
A61K 38/50
A61K 31/4184
A61K 31/704
A61K 31/519
A61K 31/454
A61K 31/404
A61K 31/506
A61K 33/243
A61K 31/7068
A61K 31/69
A61K 38/06
A61P 35/00

Abstract:

The present invention relates to the use of bifunctional compositions in methods of treating or preventing cancer. The compositions comprise a DNA ligand and a protein ligand for the treatment or prevention of cancer, wherein the DNA ligand interferes with DNA metabolism and the protein ligand interferes with signaling pathways. In particular, the present invention relates to the use of pyronaridine in methods of treating of preventing cancer. The invention also relates to compositions, compounds and medicaments comprising a DNA ligand and a protein ligand, for example, compositions, compounds and medicaments comprising pyronaridine.