A sprayable emulsion is provided. The emulsion can be used in the treatment of various skin conditions. The emulsion includes a hydrofluoro-based propellant, an emulsification system, an oil phase, a water phase, and active agent particles. Further, the emulsification system includes at least one nonionic emulsifier. The emulsion has a viscosity ranging from about 500 centipoise to about 10,000 centipoise and a hydrophilic to lipophilic balance (HLB) value of from about 2 to about 12. The present inventors have found that by selectively controlling the nature of the emulsification system and the viscosity of the emulsion, the active agent particles resist settling such that a substantially homogeneous distribution of the active agent particles is maintained and can be evenly sprayed onto a surface without running once applied.
Sprayable Composition Containing Zinc Oxide And A Fluoro-Olefin Propellant
- San Antonio TX, US Renee Nelson - Brandon FL, US Brian Wagner - Henderson NV, US Mary Walter - Vancouver WA, US
International Classification:
A61K 9/12 A61K 33/30 A61K 9/00 A61K 47/06
Abstract:
A sprayable zinc oxide composition is provided. The sprayable zinc oxide composition can be used in the treatment of various skin conditions. The sprayable zinc oxide composition includes zinc oxide particles and a fluoro-olefin propellant. The present inventors have found that by selecting a propellant having a certain specific gravity, vapor pressure, and molecular weight, and by controlling the viscosity of the various components of the composition, the resulting zinc oxide composition resists settling such that a substantially homogeneous distribution of zinc oxide particles is maintained and can be evenly sprayed onto a surface without running once applied.
Stabilized, Sprayable Emulsion Containing Active Agent Particles
A sprayable emulsion is provided. The emulsion can be used in the treatment of various skin conditions. The emulsion includes a hydrofluoro-based propellant, an emulsification system, an oil phase, a water phase, and active agent particles. Further, the emulsification system includes at least one nonionic emulsifier. The emulsion has a viscosity ranging from about 500 centipoise to about 10,000 centipoise and a hydrophilic to lipophilic balance (HLB) value of from about 2 to about 12. The present inventors have found that by selectively controlling the nature of the emulsification system and the viscosity of the emulsion, the active agent particles resist settling such that a substantially homogeneous distribution of the active agent particles is maintained and can be evenly sprayed onto a surface without running once applied.
A spray delivery system including a sprayable active agent composition housed within a container is provided that can be used in the treatment of various skin conditions. The composition includes a hydrofluoro-based propellant, a carrier fluid, and active agent particles, and has a viscosity ranging from about 500 centipoise to about 10,000 centipoise. The container includes a dip tube; a valve assembly that includes a valve body, a stem comprising a stem orifice, and a vapor tap; and an actuator. The dip tube is coupled to the actuator by the valve assembly, and the actuator is depressed to dispense the emulsion. By selectively controlling the components and viscosity of the composition and the dimensions of the container components, the active agent particles resist settling so a substantially homogeneous distribution of the particles is maintained. Thus, the composition can be evenly dispensed from the container as a fine mist without clogging.
Scripps ClinicScripps Clinic Obstetrics & Gynecology 9850 Genesee Ave STE 600, La Jolla, CA 92037 8584530753 (phone), 8584581002 (fax)
Education:
Medical School George Washington University School of Medicine and Health Science Graduated: 1997
Procedures:
Cesarean Section (C-Section) Colposcopy D & C Dilation and Curettage Delivery After Previous Caesarean Section Hysterectomy Myomectomy Ovarian Surgery Tubal Surgery Vaccine Administration Vaginal Delivery
Conditions:
Breast Disorders Complicating Pregnancy or Childbirth Spontaneous Abortion Abnormal Vaginal Bleeding Candidiasis of Vulva and Vagina
Languages:
English Korean Spanish
Description:
Dr. Nelson graduated from the George Washington University School of Medicine and Health Science in 1997. She works in La Jolla, CA and specializes in Obstetrics & Gynecology. Dr. Nelson is affiliated with Scripps Memorial Hospital Encinitas and Scripps Memorial Hospital La Jolla.
Kaiser Permanente Medical GroupKaiser Permanente Sacramento Medical Center 2345 Fair Oaks Blvd, Sacramento, CA 95825 9169735000 (phone), 9164806424 (fax)
Education:
Medical School University of California, San Francisco School of Medicine Graduated: 1998
Procedures:
Destruction of Benign/Premalignant Skin Lesions Sigmoidoscopy Vaccine Administration
Dr. Nelson graduated from the University of California, San Francisco School of Medicine in 1998. She works in Sacramento, CA and specializes in Family Medicine.
Sharp Community Medical GroupPulmonary Medicine & Infectious Diseases Medical Group 6699 Alvarado Rd STE 2308, San Diego, CA 92120 6194629010 (phone), 6192878165 (fax)
Education:
Medical School Saint Louis University School of Medicine Graduated: 1990
Dr. Nelson graduated from the Saint Louis University School of Medicine in 1990. She works in San Diego, CA and specializes in Pulmonary Critical Care Medicine. Dr. Nelson is affiliated with Alvarado Hospital LLC, Promise Hospital Of San Diego, Sharp Grossmont Hospital and Vibra Hospital Of San Diego.
El Rancho Elementary School Camarillo CA 1974-1975, John Dolland Elementary School Norwalk CA 1978-1980, Los Nogales Elementary School Camarillo CA 1980-1980, Los Altos Intermediate School Camarillo CA 1981-1982
Community:
Benny Esparza
Biography:
Married for 18+ yrs, mother of 3 beautiful boys ages 24, 15 & 13, Grandmother to 1 a...