Renu E Gupta

US Patent:

20180311267, Nov 1, 2018

Filed:

Jun 13, 2018

Appl. No.:

16/007075

Inventors:

- Bridgewater NJ, US
Renu GUPTA - Morristown NJ, US

International Classification:

A61K 31/7036
A61K 9/00
A61K 9/127
A61K 45/06
A61K 31/133
A61K 31/546
A61K 31/65
A61K 31/7048
A61K 31/7052
A61K 31/407
A61K 31/4375
A61K 31/4409
A61K 31/4709
A61K 31/496
A61K 31/5383

Abstract:

Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and/or NTM culture conversion to negative during or after the administration period.