A method of removing toxins from a patients blood comprises implanting a filter device having a dialysis membrane with an exterior surface exposed to the patients blood and a dialysate cavity exposed to an interior surface of the dialysate membrane within a blood vessel of a patient, continuously directing substantially uncontaminated or substantially decontaminated dialysate into the dialysate cavity and in diffusive communication with the patients blood, dialysing the patients blood with the dialysate, and continuously removing toxin contaminated dialysate from the filter device.
Process And Apparatus For Utilization Of In Vivo Extracted Plasma With Tissue Engineering Devices, Bioreactors, Artificial Organs, And Cell Therapy Applications
Reynolds G. Gorsuch - Napa CA Transvivo, Inc. - Napa CA
International Classification:
A61M 3700
US Classification:
604 501, 604 604, 604 609
Abstract:
The present invention is directed to a method of treating cells, tissues or organs using in vivo plasma separation by implanting a plasma separation filter device within a blood vessel of a patient, or allogenic, or xenogenic donor, continuously separating blood plasma from whole blood in vivo, directing the plasma from the plasma separation filter device to a bioreactor, and exposing the plasma to cells, tissue or an organ within the bioreactor utilizing immune separation membranes where necessary.
Apparatus And Method For Selective Reduction Of Segmental Intracellular And Extracellular Edema
Reynolds G. Gorsuch - Yountville CA Kris Venkat - Somerset NJ
Assignee:
Transvivo, Inc. - Napa CA
International Classification:
A61M 3700
US Classification:
604 604, 604 609, 604 611, 604 9
Abstract:
Segmental edema is treated by inserting a plasma extraction filter device in a major vein of a body segment or servicing the body segment containing the edemic tissues, and inserting a return catheter in a major artery of the body segment affected or feeding the body segment from which plasma is extracted. Blood plasma and plasma proteins extracted from the edemic body segment through the plasma extraction filter fluids are directed to an ultrafiltration apparatus where plasma water is separated from the plasma proteins. Plasma proteins are returned to the body segment from which the plasma was extracted via the return catheter in the major artery of the subject body segment.
Apparatus And Method For In-Vivo Plasmapheresis Using Periodic Backflush
Apparatus and method for in-vivo plasmapheresis utilizing a plurality of elongated hollow microporous filter fibers periodically interrupt diffusion of blood plasma from a patient, and, for a selected time, backflush fluid into the fibers at a pressure and interval sufficient to cleanse the fiber pores, after which plasma diffusion is resumed.
Specialized Hollow Fiber Membranes For In-Vivo Plasmapheresis And Ultrafiltration
An in-vivo plasmapheresis and/or in-vivo ultrafiltration membrane comprises a plurality of elongated hollow fibers each fiber having an interior lumen extending along the fiber length, the fiber wall having a plurality of zones between the inner and outer wall surfaces, each of the zones having a mass density different than the mass density of an adjacent zone. The fiber wall is characterized by having a lower mass density zone at the inner wall surface and a higher mass density zone at the outer wall surface.
Specialized Hollow Fiber Membranes For In-Vivo Plasmapheresis And Ultrafiltration
Reynolds Gorsuch - Yountville CA Henry Grage - Danville CA
Assignee:
Transvivo Inc. - Napa CA
International Classification:
B01D 6302
US Classification:
21050023, 21050041, 604 604, 604 609, 604 27
Abstract:
An in-vivo plasmapheresis and/or in-vivo ultrafiltration membrane comprises a plurality of elongated hollow fibers each fiber having an interior lumen extending along the fiber length, the fiber wall having a plurality of zones between the inner and outer wall surfaces, each of the zones having a mass density different than the mass density of an adjacent zone. The fiber wall is characterized by having a lower mass density zone at the inner wall surface and a higher mass density zone at the outer wall surface.
A method for carrying out therapeutic apheresis comprises separating plasma from whole blood in-vivo and removing selected disease-related components from the separated plasma. Apparatus for carrying out therapeutic apheresis includes a filter device for being implanted in a blood vessel for carrying out in-vivo plasma separation having one or more elongated hollow tubes and a plurality of elongated hollow microporous fibers capable of separating plasma from whole blood at pressure and blood flow within a patient's vein, a multiple lumen catheter secured to the proximal end of the filter device having one or more lumens in fluid communication with the interior of said one or more hollow tubes and a plasma return lumen, and therapeutic apheresis apparatus for removing and/or separating selected disease-related components from the separated plasma and means for directing plasma between said catheter and the selective component removal apparatus.
Plasmapheresis Filter Device And Catheter Assembly
Reynolds G. Gorsuch - Yountville CA, US Harold W. Peters - Martinez CA, US
Assignee:
Transvivo, Inc. - Napa CA
International Classification:
A61M001/34
US Classification:
604 609, 604 604, 604 504
Abstract:
A filter device for being implanted in a blood vessel for carrying out in-vivo plasma separation comprises one or more elongated hollow tubes and a plurality of elongated hollow microporous fibers, each fiber having a first and second end secured to one or more of the elongated hollow tubes with the interior lumen of each of the fibers communicating with the interior of the one or more of the hollow tubes, and wherein the fiber wall has a higher mass density zone adjacent to the outer wall surface and a lower mass density zone adjacent to the inner wall surface.