Ricardo J Moran

US Patent:

6586256, Jul 1, 2003

Filed:

May 2, 2000

Appl. No.:

09/562202

Inventors:

Timothy E. Glass - State College PA
Joseph Raker - State College PA
Ricardo Moran - Washington DC

Assignee:

The Penn State Research Foundation

International Classification:

G01N 2164

US Classification:

436164, 436172, 552101, 564305

Abstract:

Chemical sensor compositions and methods for quantifying analytes are described. The chemical sensors include analyte-binding moieties and reporter moieties covalently attached to a framework including two trityl groups connected by a linear spacer such as ethyne or butadiyne. The sensors chelate an analyte across the acetylene axis of the molecule to stabilize the molecule in an eclipsed rotamer conformation. This conformation causes the sensors to emit a measurable signal. Also disclosed are methods of making the chemical sensors, methods of using the chemical sensors, and kits for quantifying analytes using the chemical.