Richard V Carroll

US Patent:

7927595, Apr 19, 2011

Filed:

Feb 20, 1998

Appl. No.:

09/027205

Inventors:

Carl H. June - Rockville MD, US
Richard G. Carroll - Gaithersburg MD, US
James L. Riley - Elkridge MD, US
Daniel C. St. Louis - Rockville MD, US
Bruce L. Levine - Cherry Hill NJ, US

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

A61K 39/395
C07K 16/28

US Classification:

4241541, 4241301, 4241431, 4241441, 4241531, 4241731, 5303871, 5303881, 5303882, 5303887, 53038875

Abstract:

Methods for modulating HIV-1 fusion cofactor expression by manipulating an accessory molecule on the surface of T cells, such as CD28, are described. The invention encompasses methods for modulating HIV-1 fusion cofactor expression by stimulating or inhibiting one or more intracellular signals which result from ligation of a surface receptor on a T cell which binds a costimulatory molecule. In one embodiment, expression of an HIV-1 fusion cofactor, such as CCR5, is downregulated by stimulating a CD28-associated signal in the T cell.

US Patent:

20060204500, Sep 14, 2006

Filed:

Mar 10, 2006

Appl. No.:

11/373777

Inventors:

Carl June - Rockville MD, US
Richard Carroll - Gaithersburg MD, US
James Riley - Elkridge MD, US
Daniel St. Louis - Rockville MD, US
Bruce Levine - Cherry Hill NJ, US

International Classification:

A61K 39/42

US Classification:

424148100

Abstract:

The invention relates to a method for modulating HIV-1 fusion cofactor expression by manipulating CTLA-4 on the surface of T cells. The invention encompasses methods for modulating HIV-1 fusion cofactor expression by inhibiting one or more intracellular signals resulting from stimulation of CTLA-4. In one embodiment, expression of the HIV-1 fusion cofactor, CCR5, is downregulated by binding of anti-CTLA-4 antibody to CTLA-4.