Richard W Carroll

US Patent:

7927595, Apr 19, 2011

Filed:

Feb 20, 1998

Appl. No.:

09/027205

Inventors:

Carl H. June - Rockville MD, US
Richard G. Carroll - Gaithersburg MD, US
James L. Riley - Elkridge MD, US
Daniel C. St. Louis - Rockville MD, US
Bruce L. Levine - Cherry Hill NJ, US

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

A61K 39/395
C07K 16/28

US Classification:

4241541, 4241301, 4241431, 4241441, 4241531, 4241731, 5303871, 5303881, 5303882, 5303887, 53038875

Abstract:

Methods for modulating HIV-1 fusion cofactor expression by manipulating an accessory molecule on the surface of T cells, such as CD28, are described. The invention encompasses methods for modulating HIV-1 fusion cofactor expression by stimulating or inhibiting one or more intracellular signals which result from ligation of a surface receptor on a T cell which binds a costimulatory molecule. In one embodiment, expression of an HIV-1 fusion cofactor, such as CCR5, is downregulated by stimulating a CD28-associated signal in the T cell.

US Patent:

20060204500, Sep 14, 2006

Filed:

Mar 10, 2006

Appl. No.:

11/373777

Inventors:

Carl June - Rockville MD, US
Richard Carroll - Gaithersburg MD, US
James Riley - Elkridge MD, US
Daniel St. Louis - Rockville MD, US
Bruce Levine - Cherry Hill NJ, US

International Classification:

A61K 39/42

US Classification:

424148100

Abstract:

The invention relates to a method for modulating HIV-1 fusion cofactor expression by manipulating CTLA-4 on the surface of T cells. The invention encompasses methods for modulating HIV-1 fusion cofactor expression by inhibiting one or more intracellular signals resulting from stimulation of CTLA-4. In one embodiment, expression of the HIV-1 fusion cofactor, CCR5, is downregulated by binding of anti-CTLA-4 antibody to CTLA-4.

US Patent:

58848231, Mar 23, 1999

Filed:

May 26, 1998

Appl. No.:

/084833

Inventors:

Richard A. Carroll - Cranston RI

Assignee:

The Lorac Company, Inc. - Providence RI

International Classification:

A47G 2582

US Classification:

223118

Abstract:

A collapsible shoe horn includes a shoe horn tongue having a generally thin and smooth body portion for aiding the user in putting on a pair of shoes. The side edges of the shoe horn tongue are slightly curved upwardly in a concave manner so that the shoe horn tongue conforms to the shape of the heel of a human foot. A neck portion is integral with and extends from the bottom of the shoe horn tongue. The neck portion has a pair of opposing flanges, each flange having a dap opening formed within the interior side thereof for receiving opposing ends of a shoe horn handle. The dap openings have a smooth dimple-like dap surface extending from the outer exposed surface of each neck flange for protecting the shoe horn user from the sharp ends of the shoe horn handle.

US Patent:

45258996, Jul 2, 1985

Filed:

Jun 27, 1983

Appl. No.:

6/507999

Inventors:

Richard A. Carroll - Cranston RI

Assignee:

Quality Services Incorporated - Cranston RI

International Classification:

B42F 300

US Classification:

24 67P

Abstract:

A fastener for paper and the like is integrally molded of a plastic material and comprises hingedly interconnected first and second plate members, each having a mating surface thereon, and a wedge-shaped prong which extends from the mating surface of the first plate member. The prong is receivable in frictional interengagement in a slot in the second plate member to detachably maintain the plate members in the closed positions thereof, wherein the abutting surfaces thereof are in mating relation. One or a plurality of sheets of paper or the like interposed between the plate members are penetrated by the prong when the plate members are in the closed positions thereof to secure the sheets in the fastener.