Richard A Cerione

age ~72

from Ithaca, NY

Also known as:
  • Richard Albert Cerione
  • Richard Alber Cerione
  • Rick A Cerione
  • Dick A Cerione
Phone and address:
7 Essex Ct, Ithaca, NY 14850
6072575397

Richard Cerione Phones & Addresses

  • 7 Essex Ct, Ithaca, NY 14850 • 6072575397
  • 391 Teton Ct, Ithaca, NY 14850
  • 600 Broadway, Vineland, NJ 08360
  • 7 Essex Ct, Ithaca, NY 14850

Us Patents

  • Effects Of Tissue Transglutaminase On Beta-Amyloid-Induced Apoptosis

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  • US Patent:
    20070123462, May 31, 2007
  • Filed:
    Nov 16, 2006
  • Appl. No.:
    11/600660
  • Inventors:
    Richard Cerione - Ithaca NY, US
    Joseph Wakshlag - Woodbury CT, US
    Marc Antonyak - Ithaca NY, US
  • Assignee:
    Cornell Research Foundation, Inc. - Ithaca NY
  • International Classification:
    A61K 38/55
    C12Q 1/48
  • US Classification:
    514012000, 435015000
  • Abstract:
    The present invention relates to a method of inhibiting beta-amyloid-induced death of neuronal cells in a subject by inhibiting human tissue transglutaminase in the subject under conditions effective to inhibit beta-amyloid-induced death of neuronal cells. Also disclosed are methods for identifying candidate compounds suitable for inhibiting beta-amyloid-induced death of neuronal cells in a subject by identifying compounds which are capable of binding to human tissue transglutaminase as candidate compounds suitable for inhibiting beta-amyloid-induced death of neuronal cells in a subject. The present invention also relates to compounds suitable for inhibiting beta-amyloid-induced death of neuronal cells in a subject, as well as methods for designing such compounds.
  • Inhibitions Of Glutaminase C

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  • US Patent:
    20120220610, Aug 30, 2012
  • Filed:
    Mar 25, 2010
  • Appl. No.:
    13/259533
  • Inventors:
    Richard A. Cerione - Ithaca NY, US
    Jon W. Erickson - Freeville NY, US
    Kristin Wilson Cerione - Ithaca NY, US
    Jianbin Wang - Ithaca NY, US
  • Assignee:
    CORNELL UNIVERSITY - Ithaca NY
  • International Classification:
    A61K 31/515
    A61K 31/4745
    A61K 31/473
    A61K 31/4196
    A61K 31/426
    A61P 35/00
    C07D 221/18
    C07D 471/04
    C07D 405/10
    C07D 249/12
    C07D 239/62
    C07D 277/06
    C12Q 1/34
    G01N 33/573
    C12N 5/071
  • US Classification:
    514270, 435375, 514285, 514284, 514384, 514365, 546 61, 546 70, 5482644, 544301, 548201, 435 18, 435 71
  • Abstract:
    The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.
  • Activating Phosphorylation Site On Glutaminase C

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  • US Patent:
    20130252983, Sep 26, 2013
  • Filed:
    Sep 12, 2011
  • Appl. No.:
    13/821834
  • Inventors:
    Kristin Wilson Cerione - Ithaca NY, US
    Richard A. Cerione - Ithaca NY, US
  • Assignee:
    CORNELL UNIVERSITY - Ithaca NY
  • International Classification:
    A61K 31/473
    A61K 31/277
    A61K 31/436
    A61K 31/515
    G01N 33/68
    C12Q 1/34
  • US Classification:
    514270, 435375, 435 74, 435 18, 514284, 506 10, 514520, 514291
  • Abstract:
    A method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting activating phosphorylation of glutaminase C under conditions effective to reduce production of glutamate from glutamine. Methods for treating or preventing a condition mediated by the activating phosphorylation of glutaminase C, detecting a condition mediated by the activating phosphorylation of glutaminase C, and screening for compounds capable of treating or preventing cancer are also disclosed.
  • Structural Basis For The Guanine Nucleotide-Binding Activity Of Tissue Transglutaminase And Its Regulation Of Transamidation Activity

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  • US Patent:
    20040259176, Dec 23, 2004
  • Filed:
    Feb 24, 2004
  • Appl. No.:
    10/785823
  • Inventors:
    Richard Cerione - Ithaca NY, US
    Jon Clardy - Boston MA, US
    Shenping Liu - Portage MI, US
  • International Classification:
    G01N033/574
    A61K031/00
  • US Classification:
    435/007230, 514/001000
  • Abstract:
    The present invention relates to methods of facilitating death of cancer cells in a subject by inhibiting tissue transglutaminase in the subject under conditions effective to facilitate death of cancer cells. Also disclosed are methods for identifying candidate compounds suitable for facilitating death of cancer cells in a subject by contacting tissue transglutaminase with a compound and identifying those compounds which bind to the tissue transglutaminase as candidate compounds suitable for facilitating death of cancer cells in a subject. The present invention also discloses methods of producing a tissue transglutaminase crystal suitable for X-ray diffraction as well as crystals produced by such methods. Also disclosed are compounds suitable for facilitating death of cancer cells in a subject as well as methods for designing such compounds.
  • Methods For Treatment Of Cancer By Targeting Sirt5

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  • US Patent:
    20190298747, Oct 3, 2019
  • Filed:
    May 17, 2019
  • Appl. No.:
    16/414912
  • Inventors:
    - Ithaca NY, US
    Richard Cerione - Ithaca NY, US
  • Assignee:
    Cornell University - Ithaca NY
  • International Classification:
    A61K 31/7016
    A61K 38/17
    A61K 38/03
    A61K 38/02
    A61K 31/702
    C07K 7/06
    A61K 31/7088
    C07K 14/47
    C12N 15/113
    A61K 31/713
    A61K 31/198
  • Abstract:
    This disclosure demonstrates that inhibition of Sirt5 can suppress malignant transformation of cells. Therefore, methods of treating cancer based on inhibition of Sirt5 are disclosed.
  • Glutaminase Inhibitors

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  • US Patent:
    20190167648, Jun 6, 2019
  • Filed:
    Feb 5, 2019
  • Appl. No.:
    16/268133
  • Inventors:
    - Pittsburgh PA, US
    - Ithaca NY, US
    Richard A. Cerione - Ithaca NY, US
    William P. Katt - Brooktondale NY, US
  • Assignee:
    University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
    Cornell University - Ithaca NY
  • International Classification:
    A61K 31/433
    C07D 285/135
    C07D 417/14
    A61K 31/4535
    C07D 401/14
    C07D 417/12
  • Abstract:
    A compound, or a pharmaceutically acceptable salt thereof, having a structure of:wherein A is a ring;
  • Glutaminase Inhibitors

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  • US Patent:
    20170290815, Oct 12, 2017
  • Filed:
    Oct 1, 2015
  • Appl. No.:
    15/516002
  • Inventors:
    - Pittsburgh PA, US
    - Ithaca NY, US
    Richard A. Cerione - Ithaca NY, US
    William P. Katt - Brooktondale NY, US
  • Assignee:
    University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
    Cornell University - Ithaca NY
  • International Classification:
    A61K 31/433
    C07D 417/14
    C07D 417/12
    A61K 31/4535
    C07D 285/135
  • Abstract:
    A compound, or a pharmaceutically acceptable salt thereof, having a structure of:wherein A is a ring;
  • Methods For Treatment Of Cancer By Targeting Sirt5

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  • US Patent:
    20140213530, Jul 31, 2014
  • Filed:
    Sep 7, 2012
  • Appl. No.:
    14/342925
  • Inventors:
    Hening Lin - Ithaca NY, US
    Richard Cerione - Ithaca NY, US
  • Assignee:
    CORNELL UNIVERSITY - Ithaca NY
  • International Classification:
    C12N 15/113
    A61K 31/7016
    A61K 31/702
    A61K 38/02
    A61K 38/03
  • US Classification:
    514 193, 514 44 A, 514 44 R, 514 54, 514 43, 514 53, 514 61
  • Abstract:
    This disclosure demonstrates that inhibition of Sirt5 can suppress malignant transformation of cells. Therefore, methods of treating cancer based on inhibition of Sirt5 are disclosed.

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