Richard Cerione - Ithaca NY, US Joseph Wakshlag - Woodbury CT, US Marc Antonyak - Ithaca NY, US
Assignee:
Cornell Research Foundation, Inc. - Ithaca NY
International Classification:
A61K 38/55 C12Q 1/48
US Classification:
514012000, 435015000
Abstract:
The present invention relates to a method of inhibiting beta-amyloid-induced death of neuronal cells in a subject by inhibiting human tissue transglutaminase in the subject under conditions effective to inhibit beta-amyloid-induced death of neuronal cells. Also disclosed are methods for identifying candidate compounds suitable for inhibiting beta-amyloid-induced death of neuronal cells in a subject by identifying compounds which are capable of binding to human tissue transglutaminase as candidate compounds suitable for inhibiting beta-amyloid-induced death of neuronal cells in a subject. The present invention also relates to compounds suitable for inhibiting beta-amyloid-induced death of neuronal cells in a subject, as well as methods for designing such compounds.
The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the cell or tissue under conditions effective to reduce production of glutamate from glutamine. Compounds for carrying out this method are also disclosed.
A method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting activating phosphorylation of glutaminase C under conditions effective to reduce production of glutamate from glutamine. Methods for treating or preventing a condition mediated by the activating phosphorylation of glutaminase C, detecting a condition mediated by the activating phosphorylation of glutaminase C, and screening for compounds capable of treating or preventing cancer are also disclosed.
Structural Basis For The Guanine Nucleotide-Binding Activity Of Tissue Transglutaminase And Its Regulation Of Transamidation Activity
Richard Cerione - Ithaca NY, US Jon Clardy - Boston MA, US Shenping Liu - Portage MI, US
International Classification:
G01N033/574 A61K031/00
US Classification:
435/007230, 514/001000
Abstract:
The present invention relates to methods of facilitating death of cancer cells in a subject by inhibiting tissue transglutaminase in the subject under conditions effective to facilitate death of cancer cells. Also disclosed are methods for identifying candidate compounds suitable for facilitating death of cancer cells in a subject by contacting tissue transglutaminase with a compound and identifying those compounds which bind to the tissue transglutaminase as candidate compounds suitable for facilitating death of cancer cells in a subject. The present invention also discloses methods of producing a tissue transglutaminase crystal suitable for X-ray diffraction as well as crystals produced by such methods. Also disclosed are compounds suitable for facilitating death of cancer cells in a subject as well as methods for designing such compounds.
Methods For Treatment Of Cancer By Targeting Sirt5
This disclosure demonstrates that inhibition of Sirt5 can suppress malignant transformation of cells. Therefore, methods of treating cancer based on inhibition of Sirt5 are disclosed.
This disclosure demonstrates that inhibition of Sirt5 can suppress malignant transformation of cells. Therefore, methods of treating cancer based on inhibition of Sirt5 are disclosed.