Richard J Cross

US Patent:

20130123258, May 16, 2013

Filed:

Oct 26, 2012

Appl. No.:

13/661300

Inventors:

Roman Manetsch - Tampa FL, US
Richard Matthew Cross - Brandon FL, US
Dennis Edward Kyle - Lithia FL, US
Tina Susanna Mutka - Tampa FL, US
Alexis Nichole LaCrue - Temple Terrace FL, US
Jordany Richarlson Maignan - Tampa FL, US
Fabian Ernesto Saenz - Quito, EC

International Classification:

C07D 215/233
C07D 413/04
C07D 401/04
C07D 215/56

US Classification:

5142352, 514312, 546156, 546153, 544128, 544363, 51425307

Abstract:

Provided are 4(1H)-quinolone derivatives effective in inhibiting or eliminating the viability of at least one of the stages in the life-cycle of the malarial parasite, and to show a reduced propensity to induce resistance to the compound by the target parasite. In particular, the compounds can be derivatives of phenoxyethoxy-quinolones, and including, but not only, 7-(2-phenoxyethoxy)quinolin derivatives. These compounds may be administered by themselves, with at least one other derivative compound, or with other antimalarial compounds, to an animal or human subject. The therapeutic compositions can be and formulated to reduce the extent of a infection in the recipient subject, or to reduce the likelihood of the onset or establishment of a infection if administered prior to the parasite contacting the subject. The therapeutic compositions can be formulated to provide an effective single dose amount of an antimalarial compound or multiple doses for administering over a period of time.