Richard Ellis Fine

US Patent:

7196108, Mar 27, 2007

Filed:

Mar 6, 2003

Appl. No.:

10/384391

Inventors:

Magnus Pfahl - Solana Beach CA, US
Catherine Tachdjian - San Diego CA, US
Hussien A. Al-Shamma - Encinitas CA, US
Andrea Fanjul Giachino - San Diego CA, US
Karine Jakubowicz-Jaillardon - Villebon sur Yvette, FR
Jianhua Guo - San Diego CA, US
Richard M. Fine - Ridgewood NJ, US
Lyle W. Spruce - Chula Vista CA, US
James W. Zapf - San Diego CA, US

Assignee:

Incyte San Diego Inc. - Wilmington DE
Ortho McNeil Pharmaceutical Inc. - Rariton NJ

International Classification:

A61K 31/343
A61K 31/381
A61K 31/382
A61K 31/403
A61K 31/4166
A61K 31/427
A61K 31/4353
A61K 31/538
A61K 31/5415
C07D 277/34
C07D 265/36
C07D 243/10
C07D 241/36
C07D 233/72
C07D 223/14
C07D 221/02
C07D 209/04
C07D 335/04
C07D 333/50
C07D 319/14
C07D 311/04
C07D 307/77

US Classification:

514366, 540544, 540553, 540582, 544 2, 544 63, 544 89, 546112, 546113, 548200, 5483111, 548452, 549 32, 549377, 549396, 549462, 51421105, 51421207, 5142305, 5142521, 514300, 514387, 514412, 514453

Abstract:

The invention relates to certain bicyclic heterocycles havng the structure shown below which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, and atherosclerosis.

US Patent:

7928111, Apr 19, 2011

Filed:

Aug 8, 2007

Appl. No.:

11/836074

Inventors:

Catherine Tachdjian - San Diego CA, US
Xiao-Qing Tang - San Diego CA, US
Sara Werner - San Diego CA, US
Qing Chen - San Diego CA, US
Guy Servant - San Diego CA, US
Xiaodong Li - San Diego CA, US
Feng Zhang - San Diego CA, US
Haitian Liu - San Diego CA, US
Albert Zlotnik - San Diego CA, US
Mark Zoller - La Jolla CA, US
Boris Klebansky - Demarest NJ, US
Richard Fine - Ridgewood NJ, US
Xinshan Kang - Pine Brook NJ, US

Assignee:

Senomyx, Inc. - San Diego CA

International Classification:

A61K 31/519

US Classification:

5142601, 424452, 424461, 424479, 424493, 544278

Abstract:

The present invention provides compounds including substituted thienopyrimidinone derivatives of Formula (IIc) as ligands for modulating chemosensory receptors:.

US Patent:

8541421, Sep 24, 2013

Filed:

Mar 18, 2011

Appl. No.:

13/051586

Inventors:

Catherine Tachdjian - San Diego CA, US
Xiao-Qing Tang - San Diego CA, US
Sara Werner - San Diego CA, US
Qing Chen - San Diego CA, US
Guy Servant - San Diego CA, US
Xiaodong Li - San Diego CA, US
Feng Zhang - San Diego CA, US
Haitian Liu - San Diego CA, US
Albert Zlotnik - San Diego CA, US
Mark Zoller - La Jolla CA, US
Boris Klebansky - Demarest CA, US
Richard Fine - Ridgewood CA, US
Xinshan Kang - Pine Brook CA, US

Assignee:

Senomyx Inc. - San Diego CA

International Classification:

A61K 31/519

US Classification:

5142601, 424452, 424461, 424479, 424493, 544278

Abstract:

The present invention provides, in part, substituted thieno[2,3-d]pyrimidines and methods of contacting compositions with such compounds to enhance the sweet taste of said compositions.

US Patent:

8633186, Jan 21, 2014

Filed:

Jun 3, 2008

Appl. No.:

12/663634

Inventors:

Catherine Tachdjian - San Diego CA, US
Donald S. Karanewsky - Escondido CA, US
Xiao-Qing Tang - San Diego CA, US
Xiaodong Li - San Diego CA, US
Feng Zhang - San Diego CA, US
Guy Servant - San Diego CA, US
Qing Chen - San Diego CA, US
Vincent Darmohusodo - Encinitas CA, US
Richard Fine - Ridgewood NJ, US
Joseph R. Fotsing - San Diego CA, US
Jeffrey Robert Hammaker - San Diego CA, US
Xinshan Kang - Pine Brook NJ, US
Rachel D. A. Kimmich - San Diego CA, US
Boris Klebansky - Demarest NJ, US
Haitian Liu - San Diego CA, US
Goran Petrovic - San Diego CA, US
Jeffrey Yamamoto - San Diego CA, US
Hong Zhang - San Diego CA, US
Albert Zlotnik - San Diego CA, US
Karen Zoller - La Jolla CA, US

Assignee:

Senomyx Inc. - San Diego CA

International Classification:

C07D 239/95
C07D 285/16
A61K 31/517
A61K 31/54

US Classification:

5142228, 544 11

Abstract:

The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e. g. , by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.

US Patent:

20030105333, Jun 5, 2003

Filed:

Mar 8, 2002

Appl. No.:

10/098184

Inventors:

Magnus Pfahl - Solana Beach CA, US
Catherine Tachdjian - San Diego CA, US
Hussien Al-Shamma - Encinitas CA, US
Andrea Fanjul - San Diego CA, US
David Pleynet - San Diego CA, US
Lyle Spruce - Chula Vista CA, US
Richard Fine - Ridgewood NJ, US
James Zapf - San Diego CA, US
Jianhua Guo - San Diego CA, US

International Classification:

C07K014/705
C07D271/06
C07D277/62
C07D271/10

US Classification:

548/131000, 548/143000, 548/252000, 530/350000

Abstract:

Disclosed are molecules that activate an RXR receptor, wherein the molecule comprises an RXR binding portion which binds the RXR receptor and comprises a side pocket contacting residue which contacts a side-pocket 1 of an RXR receptor.

US Patent:

20050209286, Sep 22, 2005

Filed:

Mar 1, 2005

Appl. No.:

11/069930

Inventors:

Magnus Pfahl - Solana Beach CA, US
Catherine Tachdjian - San Diego CA, US
Hussien Al-Shamma - Encinitas CA, US
Andrea Fanjul - San Diego CA, US
David Pleynet - San Diego CA, US
Lyle Spruce - Chula Vista CA, US
Richard Fine - Ridgewood NJ, US
James Zapf - San Diego CA, US
Jianhua Guo - San Diego CA, US

International Classification:

A61K031/4439
A61K031/4245
G06F019/00
G01N033/48
G01N033/50
C07D285/14

US Classification:

514341000, 514364000, 546269100, 548134000, 702019000

Abstract:

Disclosed are molecules that activate an RXR receptor, wherein the molecule comprises an RXR binding portion which binds the RXR receptor and comprises a side pocket contacting residue which contacts a side-pocket 1 of an RXR receptor.

US Patent:

20080306076, Dec 11, 2008

Filed:

Jun 8, 2007

Appl. No.:

11/760666

Inventors:

Xiaodong Li - San Diego CA, US
Feng Zhang - San Diego CA, US
Hong Xu - San Diego CA, US
Catherine Tachdjian - San Diego CA, US
Sara Werner - San Diego CA, US
Andrew Patron - San Marcos CA, US
Albert Zlotnik - San Diego CA, US
Mark Zoller - La Jolla CA, US
Boris Klebansky - Demarest NJ, US
Richard Fine - Ridgewood NJ, US
Xinshan Kang - Pine Brook NJ, US

Assignee:

SENOMYX, INC. - San Diego CA

International Classification:

A61K 31/495
A61P 27/00
C07D 487/00
C12N 5/06
G01N 33/53
G06G 7/48

US Classification:

514249, 435375, 435 71, 544236, 703 11

Abstract:

The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

US Patent:

20080306093, Dec 11, 2008

Filed:

Jun 8, 2007

Appl. No.:

11/760592

Inventors:

Guy Servant - San Diego CA, US
Xiaodong Li - San Diego CA, US
Feng Zhang - San Diego CA, US
Haitian Liu - San Diego CA, US
Catherine Tachdjian - San Diego CA, US
Xiao-Qing Tang - San Diego CA, US
Sara Werner - San Diego CA, US
Qing Chen - San Diego CA, US
Albert Zlotnik - San Diego CA, US
Mark Zoller - La Jolla CA, US
Boris Klebansky - Demarest NJ, US
Richard Fine - Ridgewood NJ, US
Xinshan Kang - Pine Brook NJ, US

Assignee:

SENOMYX, INC. - San Diego CA

International Classification:

A61K 31/495
A61K 31/517
A61K 31/519
A61P 27/00
C07D 487/00
C12N 5/06
G01N 33/53
G06G 7/48

US Classification:

5142601, 435375, 435 71, 5142663, 5142664, 544236, 703 11

Abstract:

The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.