Richard Dennis Fitzpatrick

US Patent:

6692732, Feb 17, 2004

Filed:

Dec 19, 2002

Appl. No.:

10/324623

Inventors:

Richard Fitzpatrick - Marblehead MA
Chad Cori Huval - Somerville MA
Caroline Isabelle Bacon Kurtz - Sudbury MA
Thomas X. Neenan - Cambridge MA

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 3174

US Classification:

424 7808, 424 781, 424 7812, 424 7813, 424 7814, 424 7831, 424 7833

Abstract:

A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.

US Patent:

6730295, May 4, 2004

Filed:

May 1, 2001

Appl. No.:

09/847053

Inventors:

Richard J. Fitzpatrick - Marblehead MA

Assignee:

Genzyme Corporation - Waltham MA

International Classification:

A61K 3174

US Classification:

424 7828, 424 7808, 424 7817, 424 7827

Abstract:

The present invention relates to the discovery that certain anionic polymers have useful antibacterial activity.

US Patent:

6955806, Oct 18, 2005

Filed:

Jan 17, 2002

Appl. No.:

10/051765

Inventors:

Richard J. Fitzpatrick - Marblehead MA, US
Keith K. Shackett - Athol MA, US
Jeffrey D. Klinger - Sudbury MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K031/785
A61K031/74
A61F013/00
C08G073/06

US Classification:

424 7836, 424 781, 424402, 424 7012, 424422, 528423

Abstract:

Disclosed are ionene polymers having antimicrobial activity. “Ionene polymers” as used in this invention are cationic polymers in which a substantial proportion of the atoms providing the positive charge are quaternized nitrogens located in the main polymeric chain or backbone of the polymer rather than in pendant groups. Also disclosed are antimicrobial compositions comprising ionene polymers and methods for treating microbial infections in mammals comprising the step of administering to a mammal, a therapeutically effective amount of at least one antimicrobial composition of the invention. Also disclosed are antimicrobial compositions comprising at least one ionene polymer and methods for preventing, inhibiting or eliminating the growth, dissemination, and/or the accumulation of microorganisms on a susceptible surface (including, but not limited to, the formation of biofilms on a susceptible surface) comprising the step of contacting such surface with a composition of the invention.

US Patent:

20020114774, Aug 22, 2002

Filed:

Jul 24, 2001

Appl. No.:

09/912253

Inventors:

Richard Fitzpatrick - Marblehead MA, US
Chad Huval - Somerville MA, US
Caroline Bacon Kurtz - Sudbury MA, US
W. Mandeville - Lynnfield MA, US
Thomas Neenan - Cambridge MA, US

Assignee:

GelTex Pharmaceuticals, Inc. - Waltham MA

International Classification:

A61K031/74

US Classification:

424/078100

Abstract:

A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.

US Patent:

20030021761, Jan 30, 2003

Filed:

Jan 17, 2002

Appl. No.:

10/051766

Inventors:

Richard Fitzpatrick - Marblehead MA, US
Philip Goddard - West Newton MA, US
Robert Barker - Canton MA, US
Keith Shackett - Athol MA, US
Jeffrey Klinger - Sudbury MA, US

Assignee:

GelTex Pharmaceuticals, Inc. - Waltham MA

International Classification:

A61K031/74

US Classification:

424/078100

Abstract:

A method of using ionene polymers for the treatment of mucositis and oral mucositis in mammals is provided. The method comprises administering to a mammal an effective amount of an ionene polymer to prophylactically or therapeutically treat mucositis.

US Patent:

20060002887, Jan 5, 2006

Filed:

May 18, 2005

Appl. No.:

11/131944

Inventors:

Richard Fitzpatrick - Marblehead MA, US
Keith Shackett - Athol MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 31/765

US Classification:

424078300, 514231800, 514316000, 514332000

Abstract:

Polymerized ionene compounds are known to be effective antimicrobial substances. It has recently been appreciated that the molecular weight can affect the safety and efficacy of ionene compounds. In particular, it has been found that low molecular weight ionene oligomers (less than 50 repeat units) are less toxic than larger polymers with identical compositions. The invention discloses a plurality of ionene oligomers.

US Patent:

20060002888, Jan 5, 2006

Filed:

May 18, 2005

Appl. No.:

11/132150

Inventors:

Richard Fitzpatrick - Marblehead MA, US
Keith Shackett - Athol MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 31/785

US Classification:

424078300

Abstract:

A method of using ionene polymers for the treatment or prevention of infections (e.g., pulmonary infections) in cystic fibrosis patients is provided. The method comprises administering to a mammal an effective amount of an ionene polymer to prophylactically or therapeutically treat infections associated with cystic fibrosis.

US Patent:

20060002889, Jan 5, 2006

Filed:

May 18, 2005

Appl. No.:

11/132156

Inventors:

Richard Fitzpatrick - Marblehead MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 31/785
C08L 61/20

US Classification:

424078300, 525428000

Abstract:

Ionene polymers are effective antipathogenic agents and can be used as a surface treatment or as a pharmaceutical agent. Ionene polymers typically are persistent in an environment because they degrade slowly, however, it is sometimes desirable to have a polymer that degrades over time. Ionene polymers that have one or more hydrolyzable groups in the polymer backbone represent a type of ionene polymer that degrades with time, and the size of the resulting polymer fragments can be controlled by the placement of the hydrolyzable groups.